Optimization and applications of CDAP labeling for the assignment of cysteines

Pharmaceutical Research

Volumn 22, Issue 7, 2005, Pages 1059-1068

  Pipes, Gary D ^a   Kosky, Andrew A ^a   Abel, Jeffrey ^a   Zhang, Yu ^a   Treuheit, Michael J ^a   Kleemann, Gerd R ^a  

^a AMGEN INC   (United States)

Author keywords

1 cyano 4 dimethylaminopyridinium tetrafluoroborate; Chemical cleavage; Cyanylation; Sulfhydryl assignment; Thiol disulfide exchange

Indexed keywords

1 CYANO 4 DIMETHYLAMINOPYRIDINIUM TETRAFLUOROBORATE; CYSTEINE DERIVATIVE; DISULFIDE; EXCIPIENT; ORGANIC SOLVENT; PEPTIDE; PROTEIN; PYRIDINIUM DERIVATIVE; SODIUM CHLORIDE; THIOL DERIVATIVE; THIOL REAGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL BOND; DISULFIDE BOND; LABELING INDEX; METHODOLOGY; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

AFFINITY LABELS; CYSTEINE; FILGRASTIM; GLYCOPROTEINS; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; NITRILES; OSTEOPROTEGERIN; PEPTIDES; PYRIDINIUM COMPOUNDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SULFHYDRYL REAGENTS;

EID: 23744482662     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-5643-3     Document Type: Article

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