An α-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition

Neuropharmacology

Volumn 42, Issue 5, 2002, Pages 706-713

  Van Den Bosch, L ^a   Van Damme, P ^a   Vleminckx, V ^a   Van Houtte, E ^a   Lemmens, G ^a   Missiaen, L ^b   Callewaert, G ^b   Robberecht, W ^a  

^a Laboratory for Neurobiology   (Belgium)

^b Campus Gathuisberg   (Belgium)

Author keywords

Mercaptoacrylic acid; ALS; Amyotrophic lateral sclerosis; Excitotoxicity; Motor neuron

Indexed keywords

1 NAPHTHYLACETYLSPERMINE; 3 (4 IODOPHENYL) 2 MERCAPTO 2 PROPENOIC ACID; 3 (5 FLUORO 3 INDOLYL) 2 MERCAPTO 2 PROPENOIC ACID; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; ACETYLCYSTEINE; ACRYLIC ACID DERIVATIVE; AK 295; AMPA RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; CALMIDAZOLIUM; CALMODULIN; CALPAIN; CALPASTATIN; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CHLORPROMAZINE; DIZOCILPINE; EPOXYSUCCINYLLEUCYLAMIDO 3 METHYLBUTANE ETHYL ESTER; KAINIC ACID; MANGANESE DERIVATIVE; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN CHLORIDE; N (4 AMINOBUTYL) 5 CHLORO 2 NAPSYLAMIDE; N METHYL DEXTRO ASPARTIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OMEGA CONOTOXIN; PD 150606; PD 151746; PEPTIDE DERIVATIVE; SPERMINE DERIVATIVE; TROLOX C; UNCLASSIFIED DRUG; VERAPAMIL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; EMBRYO; ENZYME INHIBITION; EXPERIMENTAL MODEL; MOTONEURON; NERVE CELL NECROSIS; NERVE CELL STIMULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ACRYLATES; ANIMALS; CALCIUM; CALMODULIN; CALPAIN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; KAINIC ACID; MOTOR NEURONS; NEURAL INHIBITION; RATS; RECEPTORS, AMPA;

EID: 0036239183     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00010-2     Document Type: Article

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