A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages

Inflammation Research

Volumn 57, Issue 4, 2008, Pages 189-198

  Huang, H ^a   Chang, E J ^a   Lee, Y ^a   Kim, J S ^a   Kang, S S ^a   Kim, H H ^a  

^a Seoul National University   (South Korea)

Author keywords

Albiflorin; Gene profiling; Lipopolysaccharide; Macrophage; Microarray; Paeoniflorin; Paeonol; RAW264.7

Indexed keywords

ALBIFLORIN; CHEMOKINE; CYTOKINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PAEONIFLORIN; PEONOL; TOLL LIKE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; GENOME; INFLAMMATION; MACROPHAGE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOIC ACIDS; BRIDGED COMPOUNDS; CELLS, CULTURED; CHEMOKINES; DRUGS, CHINESE HERBAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSIDES; INFLAMMATION; INTERLEUKINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TOLL-LIKE RECEPTORS;

EID: 42649116083     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-7190-3     Document Type: Article

References (38)

1. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998; 392: 565-568.
2. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2: 675-80.
3. Erridge C, Bennett-Guerrero E, Poxton IR. Structure and function of lipopolysaccharides. Microbes Infect 2002; 4: 837-51.
4. Poltorak A, He X, Smirnova I. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-8.
5. Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore KJ, Gros P et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 1999; 189: 615-25.
6. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300: 1524-5.
7. Horng T, Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2001; 2: 835-41.
8. Tsuboi H, Hossain K, Akhand AA, Takeda K, Du J, Rifa'i M et al. Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. J Cell Biochem 2004; 93: 162-72.
9. Leem K, Kim H, Boo Y, Lee HS, Kim JS, Yoo YC et al. Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. Phytother Res 2004; 18: 241-3.
10. Kadota S, Terashima S, Basnet P, Kikuchi T, Namba T. Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase. Chem Pharm Bull 1993; 41: 487-90.
11. Yan D, Saito K, Ohmi Y, Fujie N, Ohtsuka K. Paeoniflorin, a novel heat shock protein-dinducing compound. Cell Stress Chaperones 2004; 9: 378-89.
12. Yamahara J, Yamada T, Kimura H, Sawada T, Fujimura H. Biologically active principles of crude drugs. II. Anti-allergic principles in "Shoseiryu- To" anti-inflammatory properties of paeoniflorin and its derivatives. J Pharmacobiodyn 1982; 5: 921-9.
13. Chou TC. Anti-inflammatory and analgesic effects of Paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol 2003; 139: 1146-52.
14. Wu H, Wei W, Song L, Zhang L, Chen Y, Hu X. Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. Int Immunopharmacol 2007; 7: 662-73.
15. Liu DZ, Xie KO, Ji XO, Ye Y, Jiang CL, Zhu XZ. Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. Br J Pharmacol 2005; 146: 604-11.
16. Liu J, Jin DZ, Xiao L, Zhu XZ. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. Brain Res 2006; 1089: 162-70.
17. Okubo T, Nagai F, Seto T, Satoh K, Ushiyama K, Kano I. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. Biol Pharm Bull 2000; 23: 199-203.
18. Lau CH, Chan CM, Chan YM, Lau KM, Lau TW, Lam FC et al. Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol. Phytomedicine 2007; 14: 778-84.
19. Mi XJ, Chen SW, Wang WJ, Wang R, Zhang YJ, Li WJ et al. Anxiolytic-like effect of paeonol in mice. Pharmacol Biochem Behav 2005; 81: 683-7.
20. Xu SP, Sun GP, Shen YX, Wei W, Peng WR, Wang H. Antiproliferation and apoptosis induction of paeonol in HepG2 cells. World J Gastroenterol 2007; 13: 250-6.
21. Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N et al. Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Toxico Appl Pharmcol 2006; 217: 35-42.
22. Kang SS, Kim JS, Yun-Choi HS, Han BH. Phytochemical studies on Paeoniae radix. Kor J Pharmacogn 1993; 24: 247-50.
23. Turner JD, Langley RS, Johnston KL, Egerton G, Wanji S, Taylor MJ. Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner. J Immunol 2006; 177: 1240-9.
24. Alcorn JF, Wright JR. Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway. Am J Physiol Lung Cell Mol Physiol 2004; 286: L129-L36.
25. Asefa B, Klarmann KD, Copeland NG, Gilbert DJ, Jenkins NA, Keller JR. The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiaion. Blood Cells Mol Dis 2004; 32: 155-67.
26. Cayabyab M, Phillips JH, Lanier LL. CD40 preferentially costimulates activation of CD4+ T lymphocytes. J Immunol 1994; 152: 1523-31.
27. Alderson MR, Armitage RJ, Touqh TW, Strockbine L, Fanslow WC, Spriqqs MK. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 1993; 178: 669-74.
28. Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN. LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microglia. Blood 2005; 106: 3114-22.
29. Hershman HR, Reddy ST, Xie W. Function and regulation of prostaglandin synthase-2. Adv Exp Med Biol 1997; 407: 61-6.
30. Newton R, Kintert LME, Bergmann M, Adcock IM, Barnes PI. Evidence for involvement of NF-kB in the transcriptional control of COX-2 gene expression by IL-1b. Biochem Biophys Res Comm 1997; 237: 28-32.
31. Fassbender K, Mielke O, Bertsch T, Muehlhauser F, Hennnerici M, Kurimoto M et al. Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases. Neurology 1999; 53: 1104-6.
32. Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 1999; 104: 1393-401.
33. Ihle JN. The Stat family in cytokine signaling. Curr Opin Cell Biol 2001: 13: 211-7.
34. Thomas KE, Galligan CL, Newman RD, Fish EN, Vogel SN. Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide. J Biol Chem 2006; 281: 31119-30.
35. Kim YM, de Vera ME, Watkins SC, Billiar TR. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 1997; 272: 1402-11.
36. Lasunskaia EB, Fridlianskaia II, Guzhova IV, Bozhkov VM, Margulis BA. Accumulation of major stress protein 70kDa protects myeloid and lymphoid cells from death by apoptosis. Apoptosis 1997; 2: 156-63.
37. Salomoni P, Khelifi AF. Daxx: death or survival protein? Trends Cell Biol 2006; 16: 97-104.
38. Michaelson JS. The Daxx enigma. Apoptosis 2000; 5: 217-20.