The Daxx enigma

Apoptosis

Volumn 5, Issue 3, 2000, Pages 217-220

  Michaelson, J S ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Apoptosis; Daxx; Fas; ND10; PML

Indexed keywords

CELL PROTEIN; DAXX PROTEIN; DNA METHYLTRANSFERASE; FAS ANTIGEN; ISOENZYME; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; CELLULAR DISTRIBUTION; CENTROMERE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD95; APOPTOSIS; CARRIER PROTEINS; CELL NUCLEUS; GENETIC TECHNIQUES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 0033859313     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009696227420     Document Type: Review

References (26)

1. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region
2. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
3. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death
4. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx
5. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development
6. Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation
7. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
8. PML is critical for ND 10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
9. Human Daxx regulates fas-induced apoptosis from nuclear PML oncogenic domains (PODs) [In Process Citation]
10. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
11. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
12. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mortl
13. A dynamic connection between centromeres and ND10 proteins
14. De novo DNA cytosine methyl-transferase activities in mouse embryonic stem cells
15. DNA hypomethylation can activate Xist expression and silence X-linked genes
16. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
17. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
18. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
19. PML is essential for multiple apoptotic pathways
20. PML induces a novel caspase-independent death process
21. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apol, and DR3 and is lethal prenatally
22. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
23. Enhanced and accelerated lymphoproliferation in Fas-null mice
24. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
25. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body
26. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling