Genotoxicity and mutagenicity of iron and copper in mice

BioMetals

Volumn 21, Issue 3, 2008, Pages 289-297

  Prá, Daniel ^a   Franke, Silvia Isabel Rech ^b   Giulian, Raquel ^a   Yoneama, Maria Lúcia ^a   Dias, Johnny Ferraz ^a   Erdtmann, Bernardo ^c   Henriques, João Antonio Pêgas ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF SANTA CRUZ DO SUL   (Brazil)

^c UNIVERSITY OF CAXIAS DO SUL   (Brazil)

Author keywords

Comet assay; Cupric sulfate; Ferrous sulfate; Micronucleus test; Transition metals

Indexed keywords

COPPER; IRON; METAL; WATER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD; BONE MARROW; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; FEEDING; FEMALE; GENOTOXICITY; LIVER LEVEL; LONG TERM EXPOSURE; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; OXIDATIVE STRESS; X RAY ANALYSIS;

ANIMALS; COPPER; FEMALE; IRON; LIVER; MALE; MICE; MUTAGENICITY TESTS;

MUS;

EID: 42549092663     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-007-9118-3     Document Type: Article

References (62)

1. Abalea V, Cillard J, Dubos MP et al (1999) Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures. Free Rad Biol Med 26(11-12):1457-1466
2. Ahmed FE (2004) Effect of diet, life style, and other environmental/chemopreventive factors on colorectal cancer development, and assessment of the risks. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 22(2):91-147
3. Anderson GJ, Frazer DM (2005) Hepatic iron metabolism. Semin Liver Dis 25(4):420-432
4. Azmi AS, Bhat SH, Hanif S et al (2006) Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. FEBS Lett 580(2):533-538
5. Beard JL (2001) Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 131(2S-2S):568S-579S (discussion 580S)
6. Box HC, Dawidzik JB, Budzinski EE (2001) Free radical-induced double lesions in DNA. Free Radic Biol Med 31(7):856-868
7. Braga C, Teixeira EC, Meira L, Wiegand F et al (2005) Elemental composition of PM10 and PM2.5 in urban environment in south Brazil. Atmos Environ 39:1801-1815
8. Brusick D, Simmon V, Rosenkranz H et al (1980) An evaluation of the Escherichia coli wp2 and wp2 uvra reverse mutation assay. Mutat Res 76:169-190
9. Budavari S, Smith A, Heckelman P et al (1996) The Merck Index-encyclopedia of chemicals, drugs and biological. Merck and Co., Rahway
10. Cabantchik ZI, Breuer W, Zanninelli G et al (2005) LPI-labile plasma iron in iron overload. Best Pract Res Clin Haematol 18(2):277-287
11. Cai L, Koropatnick J, Cherian MG (1995) Metallothionein protects DNA from copper-induced but non iron-induced cleavage in vitro. Chem Biol Interact 96:143-155
12. Campbell JL, Hopman TL, Maxwell JA et al (2000) The Guelph PIXE software package III: alternative proton database. Nucl Instrum Methods Phys Res B 170:193-204
13. Canton JH, Heijna-Merkus E, Janus JA et al (1989) Integrated criteria document: copper: effects. Appendix to report No. 758474009. National Institute of Public Health and Environmental Protection, The Netherlands
14. Chu WK, Mayer JW, Nicolet MA (1978) Backscattering spectrometry. Academic, New York
15. da Silva J, Herrmann SM, Heuser V, et al (2002) Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test. Food Chem Toxicol 40(7):941-947
16. De Freitas JM, Meneghini R (2001) Iron and its sensitive balance in the cell. Mutat Res 475(1-2):153-159
17. Dias JF, Bulla A, Yoneama ML (2002) Charging effects in thick insulating samples. Nucl Instrum Methods Phys Res B 189:72
18. Dunkel VC, San RH, Seifried HE et al (1999) Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells. Environ Mol Mutagen 33(1):28-41
19. Franke SIR, Pra D, da Silva J et al (2005a) Possible repair action of vitamin C on DNA damage induced by methyl methanesulfonate, cyclophosphamide, FeSO4 and CuSO4 in mouse blood cells in vivo. Mutat Res/Genet Toxicol Environ Mutagen 583(1):75-84
20. Franke SIR, Pra D, Erdtmann B et al (2005b) Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis. Mutagenesis 20(4):279-283
21. Franke SIR, Pra D, Dias JF et al (2006) Influence of orange juice in the levels and in the genotoxicity of iron and copper. Food Chem Toxicol 44(3):425-435
22. Fredriksson A, Schroder N, Eriksson P et al (1999) Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice. Toxicol Appl Pharmacol 159(1):25-30
23. Fujimoto Y, Ohtsuka S, Miyashita H et al (2005) Effect of tetrahydrobiopterin on copper-mediated DNA oxidation: its prooxidant property. J Clin Biochem Nutr 36(2):51-57
24. Guecheva TN, Henriques JAP, Erdtmann B (2001) Genotoxic effects of copper sulphate in freshwater planarian in vivo, studied with the single-cell gel test (comet assay). Mutat Res 497(1-2):19-27
25. Halliwell B, Guterridge JMC (2000) Free radicals in biology and medicine. Oxford University Press, New York
26. Hartmann A, Agurell E, Beevers C et al (2003) Recommendations for conducting the in vivo alkaline comet assay. 4th International Comet Assay Workshop. Mutagenesis 18(1):45-51
27. Heidelberger C, Freeman AE, Pienta RJ et al (1983) Cell transformation by chemical agents-a review and analysis of the literature: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 114(3):283-385
28. Institute of medicine (IOM) (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, molybdenum, nickel, silicon, vanadium and zinc. Food and Nutrition Board, National Academy Press, Washington
29. Johansson SA, Campbell JL, Malmqvist KG (1995) Particle-induced x-ray emission spectrometry (PIXE). Wiley, New York
30. Kern AL, Bonatto D, Dias JF et al (2004) The importance of yeast Alr proteins in cadmium detoxification as indicated by particle-induced X-ray emission and phenotypic analyses. X-Ray Spectrometry 10.1002/xrs.835
31. Kruszewski M (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 531(1-2):81-92
32. Lee WR, Abrahamson S, Valencia R et al (1983) The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 123(2):183-279
33. Leifer Z, Kada T, Mandel M et al (1981) An evaluation of tests using DNA repair-deficient bacteria for predicting genotoxicity and carcinogenicity: a report of the U.S. EPA's Gene-TOX Program. Mutat Res 87(3):211-297
34. Lewis RJ (1996) Sax's dangerous properties of industrial materials. Van Nostrand Reinhold, New York
35. Linder MC (2001) Copper and genomic stability in mammals. Mutat Res 475(1-2):141-152
36. Lloyd DR, Phillips DH, Carmichael PL (1997) Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack. Chem Res Toxicol 10(4):393-400
37. Lloyd DR, Carmichael PL, Phillips DH (1998) Comparison of the formation of 8-hydroxy-2'-deoxyguanosine and single- and double-strand breaks in DNA mediated by Fenton reactions. Chem Res Toxicol 11(5):420-427
38. Ma Y, Cao L, Kawabata T et al (1998) Cupric nitrilotriacetate induces oxidative DNA damage and apoptosis in human leukemia HL-60 cells. Free Radic Biol Med 25(4-5):568-575
39. MacGregor JT, Heddle JA, Hite M et al (1987) Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes. Mutat Res 189(2):103-112
40. Maxwell JA, Campbell JL, Teesdale WJ (1989) The Guelph PIXE software package. Nucl Instrum Methods Phys Res B 43:218-230
41. Maxwell JA, Teesdale WJ, Campbell JL (1995) The Guelph PIXE software package II. Nucl Instrum Methods Phys Res B 95:407-421
42. Meneghini R (1997) Iron homeostasis, oxidative stress, and DNA damage. Free Radic Biol Med 23(5):783-792
43. Nadin S, Vargas-Roig L, Ciocca D (2001) A silver staining method for single-cell gel assay. J Histochem Cytochem 49(9):1183-1186
44. Nakano M, Kawanishi Y, Kamohara S et al (2003) Oxidative DNA damage (8-hydroxydeoxyguanosine) and body iron status: a study on 2507 healthy people. Free Radic Biol Med 35(7):826-832
45. Oikawa S, Kawanishi S (1998) Distinct mechanisms of site-specific DNA damage induced by endogenous reductants in the presence of iron(III) and copper(II). Biochim Biophys Acta 1399(1):19-30
46. Oppenheimer SJ (2001) Iron and its relation to immunity and infectious disease. J Nutr 131(2):616S-635S
47. Rae TD, Schmidt PJ, Pufahl RA et al (1999) Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science 284(5415):805-808
48. Rojas E, Herrera LA, Poirier LA et al (1999) Are metals dietary carcinogens? Mutat Res 443(1-2):157-181
49. Saleha Banu B, Ishaq M, Danadevi K et al (2004) DNA damage in leukocytes of mice treated with copper sulfate. Food Chem Toxicol 42(12):1931-1936
50. Schumann K (2001) Safety aspects of iron in food. Ann Nutr Metab 45(3):91-101
51. Singh NP, Muller CH, Berger RE (2003) Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil Steril 80(6):1420
52. Tice RR, Agurell E, Anderson D et al (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35(3):206-221
53. Tkeshelashvili LK, McBride T, Spence K et al (1991) Mutation spectrum of copper-induced DNA damage. J Biol Chem 266(10):6401-6406
54. Troppmann L, Gray-Donald K, Johns T (2002) Supplement use: is there any nutritional benefit? J Am Diet Assoc 102(6):818-825
55. Tucker JD, Auletta A, Cimino MC et al (1993) Sister-chromatid exchange: second report of the Gene-Tox Program. Mutat Res 297(2):101-180
56. Uriu-Adams JY, Rucker RB, Commisso JF et al (2005) Diabetes and dietary copper alter 67Cu metabolism and oxidant defense in the rat. J Nutr Biochem 16(5):312
57. Valko M, Morris H, Cronin MT (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12(10):1161-1208
58. Vig BK (1982) Soybean (Glycine max [L.] merrill) as a short-term assay for study of environmental mutagens: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 99(3):339-347
59. Vyoral D, Petrak J (2005) Hepcidin: a direct link between iron metabolism and immunity. Int J Biochem Cell Biol 37(9):1768
60. Yamamoto K, Kawanishi S (1989) Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide. J Biol Chem 264(26):15435-15440
61. Yoshino M, Haneda M, Naruse M et al (1999) Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2′-deoxyguanosine in DNA. Mol Genet Metab 68(4):468-472
62. Zimmermann FK, von Borstel RC, von Halle ES et al (1984) Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 133(3):199-244