Oxidative DNA damage (8-hydroxydeoxyguanosine) and body iron status: A study on 2507 healthy people

Free Radical Biology and Medicine

Volumn 35, Issue 7, 2003, Pages 826-832

  Nakano, Masaru ^a   Kawanishi, Yoshikazu ^a   Kamohara, Seika ^a   Uchida, Yoshiko ^a   Shiota, Mami ^a   Inatomi, Yuka ^a   Komori, Toyonori ^a   Miyazawa, Katsumi ^a   Gondo, Kazumi ^b   Yamasawa, Ikuhiro ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b SRL INC   (Japan)

Author keywords

8 hydroxydeoxyguanosine (8 OHdG); Body iron status; Free radicals; Oxidative DNA damage; Oxidative stress; Serum ferritin; Total iron binding capacity (TIBC)

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; FERRITIN; FREE RADICAL; IRON;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLEEDING; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; IRON BINDING CAPACITY; IRON STORAGE; MALE; OXIDATIVE STRESS; PREMENOPAUSE; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; URINALYSIS; URINARY EXCRETION;

EID: 10744223646     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(03)00432-5     Document Type: Article

References (33)

1. Stevens R.G., Jones D.Y., Micozzi M.S., Taylor P.R. Body iron stores and the risk of cancer. N. Engl. J. Med. 319:1988;1047-1052.
2. Salonen J.T., Nyyssonen K., Korpela H., Tuomilehto J., Seppanen R., Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation. 86:1992;803-811.
3. Sempos C.T., Looker A.C., Gillum R.F., Makuc D.M. Body iron stores and the risk of coronary heart disease. N. Engl. J. Med. 330:1994;1119-1124.
4. Kasai H., Crain P.F., Kuchino Y., Nishimura S., Ootsuyama A., Tanooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 7:1986;1849-1851.
5. Fraga C.G., Shigenaga M.K., Park J.W., Degan P., Ames B.N. Oxidative damage to DNA during aging 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine . Proc. Natl. Acad. Sci. USA. 87:1990;4533-4537.
6. Loft S., Vistisen K., Ewertz M., Tjonneland A., Overvad K., Poulsen H.E. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans influence of smoking, gender and body mass index . Carcinogenesis. 13:1992;2241-2247.
7. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P.B., Woodall A.A., Yeo H.C., Ames B.N. DNA oxidation matters the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine . Proc. Natl. Acad. Sci. USA. 95:1998;288-293.
8. Halliwell B. Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am. J. Clin. Nutr. 72:2000;1082-1087.
9. Halliwell B., Gutteridge J.M.C. Free radicals in biology and medicine. 1999;Oxford University Press, Oxford, UK.
10. Szabo C., Ohshima H. DNA damage induced by peroxynitrite subsequent biological effect . Nitric Oxide. 1:1997;373-385.
11. Rosenquist T.A., Zharkov D.O., Grollman A.P. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc. Natl. Acad. Sci. USA. 94:1997;7429-7434.
12. Shinmura K., Kasai H., Sasaki A., Sugimura H., Yokota J. 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity. Mutat. Res. 385:1997;75-82.
13. Oda H., Nakabeppu Y., Furuichi M., Sekiguchi M. Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products. J. Biol. Chem. 272:1997;17843-17850.
14. Yakushiji H., Maraboeuf F., Takahashi M., Deng Z.S., Kawabata S., Nakabeppu Y., Sekiguchi M. Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity. Mutat. Res. 384:1997;181-194.
15. Hayakawa H., Hofer A., Thelander L., Kitajima S., Cai Y., Oshiro S., Yakushiji H., Nakabeppu Y., Kuwano M., Sekiguchi M. Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. Biochemistry. 38:1999;3610-3614.
16. Taddei F., Hayakawa H., Bouton M., Cirinesi A., Matic I., Sekiguchi M., Radman M. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science. 278:1997;128-130.
17. Johnson C.L., Rifkind B.M., Sempos C.T., Carroll M.D., Bachorik P.S., Briefel R.R., Gordon D.J., Burt V.L., Brown C.D., Lippel K., Cleeman J.I. Declining serum total cholesterol levels among US adults. The National Health and Nutrition Examination Surveys. JAMA. 269:1993;3002-3008.
18. Grodstein F., Stampfer M.J., Colditz G.A., Willett W.C., Manson J.E., Joffe M., Rosner B., Fuchs C., Hankinson S.E., Hunter D.J., Hennekens C.H., Speizer F.E. Postmenopausal hormone therapy and mortality. N. Engl. J. Med. 336:1997;1769-1775.
19. The measurement of total and unsaturated iron-binding capacity in serum. Br. J. Haematol. 38:1978;281-287.
20. Lipschitz D.A., Cook J.D., Finch C.A. A clinical evaluation of serum ferritin as an index of iron stores. N. Engl. J. Med. 290:1974;1213-1216.
21. Bogdanov M.B., Beal M.F., McCabe D.R., Griffin R.M., Matson W.R. A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices a one-year evaluation of methods . Free Radic. Biol. Med. 27:1999;647-666.
22. Kasai H., Iwamoto-Tanaka N., Miyamoto T., Kawanami K., Kawanami S., Kido R., Ikeda M. Life style and urinary 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage effects of exercise, working conditions, meat intake, body mass index, and smoking . Jpn. J. Cancer Res. 92:2001;9-15.
23. Holmberg I., Stal P., Hamberg M. Quantitative determination of 8-hydroxy-2′-deoxyguanosine in human urine by isotope dilution mass spectrometry normal levels in hemochromatosis . Free Radic. Biol. Med. 26:1999;129-135.
24. Erhola M., Toyokuni S., Okada K., Tanaka T., Hirai H., Ochi H., Uchida K., Osawa T., Nieminen M.M., Alho H., Kellokumpu-Lehtinen P. Biomarker evidence of DNA oxidation in lung cancer patients association of chemotherapy, and response to treatment . FEBS Lett. 409:1997;287-291.
25. Toyokuni S., Tanaka T., Hattori Y., Nishiyama Y., Yoshida A., Uchida K., Hirai H., Ochi H., Osawa T. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1 its application of ferric nitrilotriacetate-induced renal carcinogenesis model . Lab. Invest. 76:1997;365-374.
26. Saito S., Yamauchi H., Hasui Y., Kurashige J., Ochi H., Yoshida K. Quantitative determination of urinary 8-hydroxydeoxyguanosine (8-OH-dg) by using ELISA. Res. Commun. Mol. Pathol. Pharmacol. 107:2000;39-44.
27. Evans M.D., Cooke M.S., Podmore I.D., Zheng Q., Herbert K.E., Lunec J. Discrepancies in the measurement of UVC-induced 8-oxo-2′-deoxyguanosine implication for the analysis of oxidative DNA damage . Biochem. Biophys. Res. Commun. 259:1999;374-378.
28. Bannister W.H., Federici G., Heath J.K., Bannister J.V. Antioxidant systems in tumour cells the levels of antioxidant enzymes, ferritin, and total iron in a human hepatoma cell line . Free Radic. Res. Commun. 1:1986;361-367.
29. Orino K., Lehman L., Tsuji Y., Ayaki H., Torti S.V., Torti F.M. Ferritin and the response to oxidative stress. Biochem. J. 357:2001;241-247.
30. Proteggente A.R., England T.G., Rice-Evans C.A., Halliwell B. Iron supplementation and oxidative damage to DNA in healthy individuals with high plasma ascorbate. Biochem. Biophys. Res. Commun. 288:2001;245-251.
31. Torti F.M., Torti S.V. Regulation of ferritin genes and protein. Blood. 99:2002;3505-3516.
32. Swain J.H., Alekel D.L., Dent S.B., Peterson C.T., Reddy M.B. Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women. Am. J. Clin. Nutr. 76:2002;165-171.
33. Arosio P., Levi S. Ferritin, iron homeostasis, and oxidative damage. Free Radic. Biol. Med. 33:2002;457-463.