Free radical-induced double lesions in DNA

Free Radical Biology and Medicine

Volumn 31, Issue 7, 2001, Pages 856-868

  Box, Harold C ^a   Dawidzik, Jean B ^a   Budzinski, Edwin E ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

DNA damage; DNA repair; Double lesions; Fenton chemistry; Free radical induced DNA damage; Free radicals; Radiation induced DNA damage; Reactive oxygen species (ROS); Tandem lesions; Vicinal lesions

Indexed keywords

8 HYDROXYGUANINE; DNA BASE; FORMAMIDE; FREE RADICAL; GLYCOLIC ACID; GUANINE; OLIGOMER; OXYGEN; POLYMER; PURINE NUCLEOSIDE;

CHEMICAL REACTION; COMPARATIVE STUDY; CYCLIZATION; DNA DAMAGE; DNA MODIFICATION; ELECTRON TRANSPORT; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION INJURY; RADIOLYSIS; REVIEW; ULTRAVIOLET RADIATION; X IRRADIATION;

ANIMALS; DNA; DNA DAMAGE; FREE RADICALS; GUANINE; HUMANS; OLIGODEOXYRIBONUCLEOTIDES; OXYGEN; REACTIVE OXYGEN SPECIES;

EID: 0035478948     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00653-0     Document Type: Review

References (73)

1. Vicinal lesions in X-irradiated DNA?
2. Characterization of the products of dinucleoside monophosphates d(GpN) irradiated in aqueous solutions
3. Free radical-induced double base lesions
4. The radiation chemistry of d(CpGpTpA) in the presence of oxygen
5. Radiation chemistry of d(ApCpGpT)
6. Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA)
7. Isolation and characterization of the products of anoxic irradiation of d(CpGpTpA)
8. Free radical-induced tandem base damage in DNA oligomers
9. Tandem lesions and other products in X-irradiated DNA oligomers
10. Overall perspective of X-ray damage to a DNA oligomer mediated by reactive oxygen species
11. 2 reactions
12. A novel vicinal lesion obtained from the oxidative photosensitization of TpdG: Characterization and mechanistic aspects
13. New trends in photobiology
14. Bildung von cyclonucleotiden bei bestrahlung wassriger lösungen von purinnucleotiden
15. Cyclisation radicalaire de la desoxy-2′adenosine en solution aqueuse, sous l'effet du rayonnement gamma
16. Radiation-induced decomposition of the purine bases within DNA and related model compounds
17. Distribution of damage in irradiated 5′-AMP: 8,5′-cyclo-AMP, 8-hydroxy-AMP, and adenine release
18. Formation of cyclopyrimidines via the direct effects of γ radiation of pyrimidine nucleosides
19. Site-specific introduction of (5′S)-5′,8-cyclo-2′-deoxyadenosine into oligodeoxyribonucleotides
20. Hydroxyl radical-induced decomposition of 2′deoxycytidine in aerated aqueous solutions
21. Synthesis and characterization of oligonucleotides containing 5′,8-cyclopurine 2′-deoxyribonucleosides: (5′R)-5′,8-cyclo-2′-deoxyadenosine, (5′S)-5′,8-cyclo-2′-deoxyguanisine, and (5′R)-5′,8-cyclo-2′-deoxyguanisine
22. Identification of radiolysis products of cytosine resulting from the deamination pathway
23. Intimate details of the conformational charactistics of deoxyribonucleosides in aqueous solution
24. Proton magnetic resonance studies of 5,6-saturated thymidine derivatives produced by ionizing radiation. Conformational analysis of 6-hydroxylated diastereoisomers
25. Radiation chemistry of a dinucleoside monophosphate and its sequence isomer
26. Characterization of γ radiation-induced decomposition products of thymdine-containing dinucleoside monophosphates by nuclear magnetic resonance spectroscopy
27. 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system
28. Oxidative DNA damage mediated by copper(II), iron(II) and nickel(II) Fenton reactions: Evidence for site-specific mechanisms in the formation of double-strand breaks, 8-hydroxydeoxyguanosine and putative intrastrand cross-links
29. Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack
30. Structural origins of bulky oxidative DNA adducts (type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence
31. Ultraviolet-inducd 8,8-adenine dehydrodimers in oligomer- and polynucleotides
32. Topics in free radical-mediated DNA damage: Purines and damage amplification-superoxic reactions-bleomycin, the incomplete radiomimetric
33. Hydroxyl radical-induced strand break formation of poly(U) in anoxic solution. Effect of dithiotheitol and tetranitromethane
34. Yields of radiation-induced main chain scission of poly U in aqueous solution: Strand break formation via base radicals
35. Double base lesions in DNA X-irradiated in the presence of absence of oxygen
36. Tandem base lesions are generated by hydroxyl radical within isolated DNA in aerated aqueous solution
37. Novel double lesion in X-irradiated DNA consists of a strand break and a base modification
38. Bleomycin-induced strand-scission of DNA
39. 2-saturated solutions
40. Gamma-irradiation of nucleic acid constituents in deaerated aqueous solutions
41. Reduction potentials of one-electron couples involving free radicals in aqueous solution
42. The pecking order of free radicals and antioxidants: Lipid peroxidation, α-tocopherol, and ascorbate
43. Protection against radiation-induced degradation of DNA bases by polyamines
44. Long-range photoinduced electron transfer through DNA helix
45. Electron transfer in di(deoxy)nucleoside phosphates in aqueous solution: Rapid migration of oxidative damage (via adenine) to guanine
46. Oxidative DNA damage through long-range electron transfer
47. Long-range oxidation of guanine by Ru(III) in duplex DNA
48. Intermolecular photoinduced electron transfer to anthraquinones linked to duplex DNA: The effect of gaps and traps on long-range radical cation migration
49. Sequence-dependent long-range hole transport in DNA
50. Oxidative charge transfer to repair thymine dimers and damage guanine bases in DNA assemblies containing tethered metallointercalators
51. Electron transfer between bases in double helical DNA
52. OH radical-induced charge migration in oligodeoxynucleotides
53. Femtosecond direct observation of charge transfer between bases in DNA
54. The differential lysis of phosphoester bonds by nuclease P1
55. Selective hydrolysis of damaged DNA by nuclease P1
56. 32P-postlabeling assay for free radical-induced DNA dmage: The formamido remnant of thymine
57. Double base lesions are produced in DNA by free radicals
58. Synthesis and enzymatic processing of oligodeoxynucleotides containing tandem base damage
59. Oxidative decay of DNA
60. Oxidative damage to DNA and its repair
61. The oxidative DNA lesion 8,5′-(S)-cyclo-2′-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells
62. Removal of oxygen free radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells
63. Synthesis and characterization of oligodeoxyribonucleotides containing tandem base damage
64. Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells
65. Enzymatic processing of radiation-induced free radical damage in DNA
66. Multiply damaged sites in DNA: Interactions with Escherichia coli endonucleases III and VIII
67. In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites
68. Clustered damages and total lesions induced in DNA by ionizing radiation: Oxidized bases and strand breaks
69. The action of Escherichia coli endonuclease III on multiply damaged sites in DNA
70. Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals
71. Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide
72. Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation