Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity

Nucleic Acids Research

Volumn 36, Issue 7, 2008, Pages 2174-2181

  Pursell, Zachary F ^a   McDonald, J Tyson ^a,c   Mathews, Christopher K ^b   Kunkel, Thomas A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 DEOXYGUANOSINE TRIPHOSPHATE; DEOXYCYTIDINE KINASE; DEOXYGUANOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG; 8 OXODEOXYGUANOSINE TRIPHOSPHATE; 8-OXODEOXYGUANOSINE TRIPHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DEOXYRIBONUCLEOTIDE; DNA DIRECTED DNA POLYMERASE;

ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA REPLICATION; DNA TEMPLATE; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MUTAGENESIS; NONHUMAN; OXIDATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; CHEMISTRY; GENETICS; HEART MITOCHONDRION; METABOLISM; MITOCHONDRION; MOUSE; WISTAR RAT;

RATTUS; RODENTIA;

ANIMALS; DEOXYGUANINE NUCLEOTIDES; DEOXYRIBONUCLEOTIDES; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; MALE; MICE; MITOCHONDRIA; MITOCHONDRIA, HEART; RATS; RATS, WISTAR;

EID: 42449137498     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn062     Document Type: Article

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