Phenotype of genetically regulated thymic involution in young BXD RI strains of mice

Scandinavian Journal of Immunology

Volumn 64, Issue 3, 2006, Pages 287-294

  Wang, X ^a   Hsu, H C ^a   Wang, Y ^a   Edwards III, C K ^b   Yang, P ^a   Wu, Q ^a   Mountz, J D ^a,c  

^a The University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; HYDROGEN PEROXIDE; INTERLEUKIN 12; INTERLEUKIN 7; INTERLEUKIN RECEPTOR; PROTEIN BAD; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4 CD8 RATIO; CELL PROLIFERATION; DNA FLANKING REGION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; MOUSE; MOUSE STRAIN; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; THYMUS;

AGING; ANIMALS; ANTIGENS, CD3; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; INTERLEUKIN-7; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; OXIDATIVE STRESS; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; SPECIES SPECIFICITY; T-LYMPHOCYTES; THYMUS GLAND;

EID: 33747078998     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2006.01813.x     Document Type: Article

References (45)

1. Aspinall R, Andrew D. Thymic involution in aging. J Clin Immunol 2000;20:250-6.
2. Hsu HC, Li L, Zhang HG, Mountz JD. Genetic regulation of thymic involution. Mech Ageing Dev 2005;126:87-97.
3. Hsu HC, Mountz JD, Williams RW et al. Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech Ageing Dev 2002;123:1145-58.
4. Hsu HC, Zhang HG, Li L et al. Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10. Genes Immun 2003;4:402-10.
5. Li L, Hsu HC, Grizzle WE et al. Cellular mechanism of thymic involution. Scand J Immunol 2003;57:410-22.
6. Takeoka Y, Taguchi N, Shultz L et al. Apoptosis and the thymic microenvironment in murine lupus. J Autoimmun 1999;13:325-34.
7. Clements JL, Yang B, Ross-Barta SE et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 1998;281:416-9.
8. Thoman ML. Early steps in T cell development are affected by aging. Cell Immunol 1997;178:117-23.
9. Thoman ML. The pattern of T lymphocyte differentiation is altered during thymic involution. Mech Ageing Dev 1995;82:155-70.
10. Siegel RM, Katsumata M, Miyashita T et al. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc Natl Acad Sci U S A 1992;89:7003-7.
11. Taub DD, Longo DL. Insights into thymic aging and regeneration. Immunol Rev 2005;205:72-93.
12. Brelinska R. Thymic epithelial cells in age-dependent involution. Microsc Res Tech 2003;62:488-500.
13. Aspinall R, Andrew D. Thymic atrophy in the mouse is a soluble problem of the thymic environment. Vaccine 2000;18:1629-37.
14. Garcia-Suarez O, Perez-Perez M, Germana A et al. Involvement of growth factors in thymic involution. Microsc Res Tech 2003;62:514-23.
15. Malpuech-Brugere C, Nowacki W, Gueux E et al. Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress. Br J Nutr 1999;81:405-11.
16. Richards SJ, Morgan GJ, Hillmen P. Analysis of T cells in paroxysmal nocturnal hemoglobinuria provides direct evidence that thymic T-cell production declines with age. Blood 1999;94:2790-9.
17. Kong F, Chen CH, Cooper MD. Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation. Immunity 1998;8:97-104.
18. Broers AE, Meijerink JP, van Dongen JJ et al. Quantification of newly developed T cells in mice by real-time quantitative PCR of T-cell receptor rearrangement excision circles. Exp Hematol 2002;30:745-50.
19. Phillips JA, Brondstetter TI, English CA et al. IL-7 gene therapy in aging restores early thymopoiesis without reversing involution. J Immunol 2004;173:4867-74.
20. Li WQ, Jiang Q, Khaled AR et al. Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. J Biol Chem 2004;279:29160-6.
21. Karawajew L, Ruppert V, Wuchter C et al. Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia. Blood 2000;96:297-306.
22. Andrew D, Aspinall R. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp Gerontol 2002;37:455-63.
23. Li L, Hsu HC, Stockard CR et al. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J Immunol 2004;172:2909-16.
24. Sempowski GD, Gooding ME, Liao HX et al. T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol Immunol 2002;38:841-8.
25. O'Brien EP, Zhen L, Jiang SY et al. High-resolution genetic mapping of the gunmetal gene which regulates platelet production. Mamm Genome 1996;7:206-8.
26. Abe N, Kohu K, Ohmori H et al. Reduction of Runx1 transcription factor activity up-regulates Fas and Bim expression and enhances the apoptotic sensitivity of double positive thymocytes. J Immunol 2005;175:4475-82.
27. Koni PA, Khanna R, Chang MC et al. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. J Biol Chem 2003;278:39443-51.
28. Andrew D, Aspinall R. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol 2001;166:1524-30.
29. Kujoth GC, Hiona A, Pugh TD et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005;309:481-4.
30. Migliaccio E, Giorgio M, Mele S et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999;402:309-13.
31. Munitic I, Williams JA, Yang Y et al. Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Blood 2004;104:4165-72.
32. Sudo T, Nishikawa S, Ohno N et al. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A 1993;90:9125-9.
33. von Freeden-Jeffry U, Vieira P, Lucian LA et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995;181:1519-26.
34. Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133-9.
35. Van Zant G, Liang Y. The role of stem cells in aging. Exp Hematol 2003;31:659-72.
36. Van Zant G, Scott-Micus K, Thompson BP et al. Stem cell quiescence/activation is reversible by serial transplantation and is independent of stromal cell genotype in mouse aggregation chimeras. Exp Hematol 1992;20:470-5.
37. Kurashima C, Utsuyama M, Kasai M et al. The role of thymus in the aging of Th cell subpopulations and age-associated alteration of cytokine production by these cells. Int Immunol 1995;7:97-104.
38. Moore NC, Anderson G, Smith CA et al. Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur J Immunol 1993;23:922-7.
39. Hsu HC, Li L, Zhang HG, Mountz JD. Genetic regulation of thymic involution. Mech Ageing Dev. 2005;126:87-97.
40. Wen R, Wang D, McKay C et al. Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. Mol Cell Biol 2001;21:678-89.
41. Akashi K, Kondo M, von Freeden-Jeffry U et al. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 1997;89:1033-41.
42. Kondo M, Akashi K, Domen J et al. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. Immunity 1997;7:155-62.
43. Potestio M, Caruso C, Gervasi F et al. Apoptosis and ageing. Mech Ageing Dev 1998;102:221-37.
44. Pawelec G, Effros RB, Caruso C et al. T cells and aging (update February 1999). Front Biosci 1999;4:D216-269.
45. Zhang N, Hartig H, Dzhagalov I et al. The role of apoptosis in the development and function of T lymphocytes. Cell Res 2005;15:749-69.