Altered cell cycle control at the G2/M phases in aryl hydrocarbon receptor-null embryo fibroblast

Molecular Pharmacology

Volumn 57, Issue 5, 2000, Pages 1056-1063

  Elizondo, Guillermo ^a,b   Fernandez Salguero, Pedro ^a,c   Sheikh, M Saeed ^a   Kim, Geum Yi ^a   Fornace, Albert J ^a   Lee, Kyung S ^a   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; DIOXIN; PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA CONTENT; DOWN REGULATION; EMBRYO; FIBROBLAST; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CELLS, CULTURED; DOWN-REGULATION; EMBRYO; FIBROBLASTS; G2 PHASE; MICE; MITOSIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034099303     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Andreola F, Fernandez-Salguero PM, Chiantore MV, Petkovich MP, Gonzalez FJ and De Luca LM (1997) Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res 57:2835-2838.
2. Basi G and Draetta G (1995) The cdc2 kinase:structure, activation and its role at mitosis in vertebrate cells, in Cell Cycle Control (Hutchison C and Glover DM eds) pp 106-143, Oxford University Press, New York.
3. Boumediene K, Vivien D, Macro M, Bogdanowicz P, Lebrun E and Pujol JP (1995) Modulation of rabbit articular chondrocyte (RAC) proliferation by TGF-beta isoforms. Cell Prolif 28:221-234.
4. Chen YH and Tukey RH (1996) Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J Biol Chem 271:26261-26266.
5. Draetta G and Beach D (1988) Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54:17-28.
6. Eblen ST, Fautsch MP, Burnette RJ, Joshi P and Leof EB (1994) Cell cycle-dependent inhibition of p34cdc2 synthesis by transforming growth factor beta 1 in cycling epithelial cells. Cell Growth Differ 5:109-116.
7. Fernandez-Salguero P, Pineau T, Hilbert DM, McPhail T, Lee SS, Kimura S, Nebert DW, Rudikoff S, Ward JM and Gonzalez FJ (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah (see comments). Science (Wash DC) 268:722-726.
8. Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM and Gonzalez FJ (1996) Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzeno-p-dioxin-induced toxicity. Toxicol Appl Pharmacol 140:173-179.
9. Fukuda K, Kojiro M and Chiu JF (1993) Induction of apoptosis by transforming growth factor-beta 1 in the rat hepatoma cell line McA-RH7777: A possible association with tissue transglutaminase expression. Hepatology 18:945-953.
10. Gaido KW, Maness SC, Leonard LS and Greenlee WF (1992) 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J Biol Chem 267:24591-24595.
11. Ge NL and Elferink CJ (1998) A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein: Linking dioxin signaling to the cell cycle. J Biol Chem 273:22708-22713.
12. Click AB, Flanders KC, Danielpour D, Yuspa SH and Sporn MB (1989) Retinoic acid induces transforming growth factor beta-2 in cultured keratinocytes and mouse epidermis. Cell Regul 1:87-97.
13. Glover DM, Hagan IM and Tavares AA (1998) Polo-like kinases: A team that plays throughout mitosis. Genes Dev 12:3777-3787.
14. Gonzalez FJ and Fernandez-Salguero P (1998) The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab Dispos 26:1194-1198.
15. 2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase. Biochem J 299:227-235.
16. Grana X and Reddy EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11:211-219.
17. Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA and Hankinson O (1991) Cloning of a factor required for activity of the Ah (dioxin) receptor. Science (Wash DC) 252:954-958.
18. Huff J, Lucier G and Tritscher A (1994) Carcinogenicity of TCDD: Experimental, mechanistic, and epidemiologic evidence. Annu Rev Pharmacol Toxicol 34:343-372.
19. Jurgensmeier JM, Schmitt CP, Viesel E, Hofler P and Bauer G (1994) Transforming growth factor beta-treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis. Cancer Res 54:393-398.
20. Kremer J, Gleichmann E and Esser C (1994) Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation. J Immunol 153:2778-2786.
21. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685.
22. Lai ZW, Hundeiker C, Gleichmann E and Esser C (1997) Cytokine gene expression during ontogeny in murine thymus on activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 52:30-37.
23. Lane HA and Nigg EA (1996) Antibody microinjection reveals an essential role for human polo-kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J Cell Biol 135:1701-1713.
24. Lanni JS and Jacks T (1998) Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18:1055-1064.
25. Lee KS, Yuan YL, Kuriyama R and Erikson RL (1995) Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1. Mol Cell Biol 15:7143-7151.
26. Ma Q and Whitlock JP Jr (1996) The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol Cell Biol 16:2144-2150.
27. Massague J (1990) The transforming growth factor-beta family. Annu Rev Cell Biol 6:597-641.
28. Murray AW and Kirschner MW (1989) Dominoes and clocks: The union of two views of the cell cycle. Science (Wash DC) 246:614-621.
29. Nielsen-Hamilton M (1990) Transforming growth factor β and its action on cellular growth and differentiation. Curr Top Dev Biol 24:95-136.
30. Norbury C, MacFarlane M, Fearnhead H and Cohen GM (1994) Cdc2 activation is not required for thymocyte apoptosis. Biochem Biophys Res Commun 202:1400-1406.
31. Nurse P (1990) Universal control mechanism regulating onset of M-phase. Nature (Lond) 344:503-508.
32. Puga A, Nebert DW and Carrier F (1992) Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA Cell Biol 11:269-281.
33. Roberts A and Sporn M (1990) Peptide growth factors and their receptors, in The Transforming Growth Factors βs (Sporn M and Roberts A eds) pp 419-472, Springer-Verlag, Berlin.
34. Rotello RJ, Lieberman RC, Purchio AF and Gerschenson LE (1991) Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells. Proc Natl Acad Sci U S A 88:3412-3415.
35. Rowlands JG and Gustafsson J (1997) Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 27:109-134.
36. Safe S, Mason G, Sawyer T, Zacharewski T, Harris M, Yao C, Keys B, Farrell K, Holcomb M, Davis D and et al (1989) Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: A review. Toxicol Ind Health 5:757-775.
37. Staples JE, Fiore NC, Frazier DE Jr, Gasiewicz TA and Silverstone AE (1998) Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 151:200-210.
38. Ucker DS (1991) Death by suicide: One way to go in mammalian cellular development? New Biol 3:103-109.
39. Wood ER and Earnshaw WC (1990) Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II. J Cell Biol 111:2839-2850.
40. Zaher H, Fernandez-Salguero PM, Letterio J, Sheikh MS, Fornace AJ Jr, Roberts AB and Gonzalez FJ (1998) The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. Mol Pharmacol 54:313-321.