Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells

Experimental Hematology

Volumn 36, Issue 5, 2008, Pages 655-666

  Orschell, Christie M ^a   Borneo, Jovencio ^a   Munugalavadla, Veerendra ^a   Ma, Peilin ^a   Sims, Emily ^a   Ramdas, Baskar ^a   Yoder, Mervin C ^a   Kapur, Reuben ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CELL ADHESION MOLECULE; CYTOKINE; HEMATOPOIETIC CELL KINASE; PROTEIN KINASE FGR; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL GROWTH; CELL HOMING; CELL POPULATION; CELL SURFACE; CONTROLLED STUDY; ENZYME DEFICIENCY; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SRC-FAMILY KINASES; STEM CELLS;

MUS;

EID: 42249083733     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.01.002     Document Type: Article

References (44)

1. Lannutti B.J., and Drachman J.G. Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 103 (2004) 3736-3743
2. Lannutti B.J., Minear J., Blake N., and Drachman J.G. Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene 25 (2006) 3316-3324
3. Lannutti B.J., Shim M.H., Blake N., Reems J.A., and Drachman J.G. Identification and activation of Src family kinases in primary megakaryocytes. Exp Hematol 31 (2003) 1268-1274
4. Borneo J., Munugalavadla V., Sims E.C., et al. Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors. Exp Hematol 35 (2007) 1026-1037
5. Mermel C.H., McLemore M.L., Liu F., et al. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood 108 (2006) 2562-2568
6. Santini V., Scappini B., Indik Z.K., Gozzini A., Ferrini P.R., and Schreiber A.D. The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal. Blood 101 (2003) 4615-4622
7. Ward A.C., Monkhouse J.L., Csar X.F., Touw I.P., and Bello P. The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor. Biochem Biophys Res Commun 251 (1998) 117-123
8. Torigoe T., O'Connor R., Santoli D., and Reed J.C. Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. Blood 80 (1992) 617-624
9. Hibbs M.L., and Harder K.W. The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling. Growth Factors Suppl (2006) 1
10. Sampson M., Zhu Q.S., and Corey S.J. Src kinases in G-CSF receptor signaling. Front Biosci 12 (2007) 1463-1474
11. Zhu Q.S., Robinson L.J., Roginskaya V., and Corey S.J. G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses. Blood 103 (2004) 3305-3312
12. Zhu Q.S., Xia L., Mills G.B., Lowell C.A., Touw I.P., and Corey S.J. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood 107 (2006) 1847-1856
13. Robinson L.J., Xue J., and Corey S.J. Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations. Exp Hematol 33 (2005) 469-479
14. Hernandez-Hansen V., Mackay G.A., Lowell C.A., Wilson B.S., and Oliver J.M. The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol 75 (2004) 143-151
15. Chin H., Arai A., Wakao H., Kamiyama R., Miyasaka N., and Miura O. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood 91 (1998) 3734-3754
16. Shivakrupa R., and Linnekin D. Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells. Cell Signal 17 (2005) 103-109
17. Korade-Mirnics Z., and Corey S.J. Src kinase-mediated signaling in leukocytes. J Leukoc Biol 68 (2000) 603-609
18. Xu Y., Harder K.W., Huntington N.D., Hibbs M.L., and Tarlinton D.M. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22 (2005) 9-18
19. Harder K.W., Parsons L.M., Armes J., et al. Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15 (2001) 603-615
20. Hibbs M.L., Tarlinton D.M., Armes J., et al. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83 (1995) 301-311
21. Chan V.W., Meng F., Soriano P., DeFranco A.L., and Lowell C.A. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7 (1997) 69-81
22. Nishizumi H., Horikawa K., Mlinaric-Rascan I., and Yamamoto T. A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med 187 (1998) 1343-1348
23. Nishizumi H., Taniuchi I., Yamanashi Y., et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3 (1995) 549-560
24. Smith K.G., Tarlinton D.M., Doody G.M., Hibbs M.L., and Fearon D.T. Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med 187 (1998) 807-811
25. Cornall R.J., Cyster J.G., Hibbs M.L., et al. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8 (1998) 497-508
26. Chan V.W., Lowell C.A., and DeFranco A.L. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol 8 (1998) 545-553
27. Meng F., and Lowell C.A. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med 185 (1997) 1661-1670
28. Meng F., and Lowell C.A. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J 17 (1998) 4391-4403
29. Orschell-Traycoff C.M., Hiatt K., Dagher R.N., Rice S., Yoder M.C., and Srour E.F. Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle. Blood 96 (2000) 1380-1387
30. Plett P.A., Frankovitz S.M., and Orschell-Traycoff C.M. In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients. Blood 100 (2002) 3545-3552
31. Plett P.A., Frankovitz S.M., and Orschell C.M. Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation. Blood 102 (2003) 2285-2291
32. Hernandez-Hansen V., Smith A.J., Surviladze Z., et al. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol 173 (2004) 100-112
33. Hong H., Kitaura J., Xiao W., et al. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 110 (2007) 2511-2519
34. Baran C.P., Tridandapani S., Helgason C.D., Humphries R.K., Krystal G., and Marsh C.B. The inositol 5′-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem 278 (2003) 38628-38636
35. Malbec O., Fong D.C., Turner M., et al. Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol 160 (1998) 1647-1658
36. Kawakami Y., Kitaura J., Satterthwaite A.B., et al. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol 165 (2000) 1210-1219
37. Kitaura J., Asai K., Maeda-Yamamoto M., Kawakami Y., Kikkawa U., and Kawakami T. Akt-dependent cytokine production in mast cells. J Exp Med 192 (2000) 729-740
38. Harder K.W., Quilici C., Naik E., et al. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104 (2004) 3901-3910
39. Walkley C.R., Shea J.M., Sims N.A., Purton L.E., and Orkin S.H. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129 (2007) 1081-1095
40. Purton L.E., Dworkin S., Olsen G.H., et al. RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J Exp Med 203 (2006) 1283-1293
41. Spangrude G.J., Brooks D.M., and Tumas D.B. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood 85 (1995) 1006-1016
42. Tajima F., Sato T., Laver J.H., and Ogawa M. CD34 expression by murine hematopoietic stem cells mobilized by granulocyte colony-stimulating factor. Blood 96 (2000) 1989-1993
43. Walkley C.R., Fero M.L., Chien W.M., Purton L.E., and McArthur G.A. Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol 7 (2005) 172-178
44. Ptasznik A., Urbanowska E., Chinta S., et al. Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J Exp Med 196 (2002) 667-678