TNF-α/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 294, Issue 4, 2008, Pages

  Jin, Shi ^a   Ray, Ramesh M ^a   Johnson, Leonard R ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Diphenyleneiodonium; Intestinal epithelial cells 6; JNK1 2; N17Rac1; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CASPASE 3; CYCLOHEXIMIDE; DIPHENYLIODONIUM SALT; DNA FRAGMENT; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; NSC 23766; PROTEIN INHIBITOR; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; INTESTINE EPITHELIUM CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MORPHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY CHAIN;

ACETYLCYSTEINE; AMINOQUINOLINES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CELL LINE; CYCLOHEXIMIDE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; HYDROGEN PEROXIDE; INTESTINAL MUCOSA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NADPH OXIDASE; ONIUM COMPOUNDS; OXIDANTS; OXIDATIVE STRESS; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RATS; REACTIVE OXYGEN SPECIES; ROTENONE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UNCOUPLING AGENTS;

EID: 42049118512     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00219.2007     Document Type: Article

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