Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract

Journal of Applied Toxicology

Volumn 28, Issue 3, 2008, Pages 303-314

  D'Cruz, Osmond J ^a,b,c   Uckun, Fatih M ^a,b,c  

^a Paradigm Pharmaceuticals   (United States)

^b PARKER HUGHES INSTITUTE   (United States)

^c Parker Hughes Clinics   (United States)

Author keywords

Contraception; Gel microemulsion; HIV AIDS; Intravaginal; Local tolerance; Microbicide; Nucleoside analog prodrug; Spermicide

Indexed keywords

5 BROMO 6 METHOXY 5,6 DIHYDRO 3' AZIDOTHYMIDINE 5' (4 BROMOPHENYL) METHOXYALANINYL PHOSPHATE; ANTIRETROVIRUS AGENT; BENZALKONIUM CHLORIDE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 8; SPERMICIDAL AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WHI 07;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; COMPARATIVE STUDY; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; EPITHELIUM; FEMALE; FLOW CYTOMETRY; GENITAL SYSTEM; GENITAL SYSTEM DISEASE; HISTOLOGY; IMMUNOASSAY; IMMUNOCOMPETENT CELL; LAMINA PROPRIA; LEUKOCYTE; MICROEMULSION; NONHUMAN; OVARY CYCLE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SWINE; UTERINE CERVIX; UTERINE CERVIX CYTOLOGY; UTERINE TUBE; UTERUS; VAGINA; VAGINA DISEASE;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-RETROVIRAL AGENTS; BENZALKONIUM COMPOUNDS; BODY FLUIDS; CYTOKINES; DIDEOXYNUCLEOTIDES; EMULSIONS; FEMALE; FLOW CYTOMETRY; GENITALIA, FEMALE; IRRITANTS; LEUKOCYTES; MUCOUS MEMBRANE; SPERMATOCIDAL AGENTS; SWINE; THYMIDINE MONOPHOSPHATE; TOXICITY TESTS; VAGINAL CREAMS, FOAMS, AND JELLIES; VAGINAL DOUCHING; ZIDOVUDINE;

SUS;

EID: 42049089736     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1280     Document Type: Article

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