Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (Compound WHI-07) in B6C3F1 mice

Journal of Applied Toxicology

Volumn 20, Issue 4, 2000, Pages 319-325

  D'Cruz, Osmond J ^a   Waurzyniak, Barbara ^a   Yiv, Seang H ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

13 week intravaginal; HIV AIDS; Microbicide; Zidovudine

Indexed keywords

5 BROMO 5,6 DIHYDRO 6 METHOXY 3' AZIDOTHYMIDINE 5' (4 BROMOPHENYL)METHOXYALANINYL PHOSPHATE; ANTIINFECTIVE AGENT; PHOSPHATE; SPERMICIDAL AGENT; UNCLASSIFIED DRUG; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH CONTROL; BODY WEIGHT; CLINICAL CHEMISTRY; CONTRACEPTION; CONTROLLED STUDY; DEVELOPMENT; DISEASE TRANSMISSION; DRUG CONCENTRATION; FEMALE; HEMATOLOGY; HETEROSEXUALITY; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROEMULSION; MORBIDITY; MORTALITY; MOUSE; NEWBORN MORTALITY; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SURVIVAL; UNITED STATES; WEIGHT REDUCTION;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-HIV AGENTS; CHEMISTRY, PHARMACEUTICAL; ERYTHROCYTE COUNT; FEMALE; MICE; ORGAN SIZE; PHOSPHORIC ACID ESTERS; REPRODUCTION; SPERMATOCIDAL AGENTS; THYMIDINE MONOPHOSPHATE; TOXICITY TESTS; WEIGHT LOSS; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; PRIMATES; RODENTIA;

EID: 0033861445     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1263(200007/08)20:4<319::AID-JAT696>3.0.CO;2-H     Document Type: Article

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