Synthesis, characterization and preclinical formulation of a dual- action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI- 07) with potent anti-HIV and spermicidal activities

Molecular Human Reproduction

Volumn 5, Issue 5, 1999, Pages 421-432

  D'Cruz, Osmond J ^a   Shin, Mei Jue ^a   Yiv, Seang H ^a   Chen, Chun Lin ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Contraceptives; HIV; Microbicide; Spermicide; ZDV

Indexed keywords

5 BROMO 5,6 DIHYDRO 6 METHOXY 3' AZIDOTHYMIDINE 5' (4 BROMOPHENYL)METHOXYALANINYL PHOSPHATE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BROMOMETHOXYZIDOVUDINE DERIVATIVE; NONOXINOL 9; SPERMICIDAL AGENT; UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG FORMULATION; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRAVAGINAL DRUG ADMINISTRATION; MALE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCANNING ELECTRON MICROSCOPY; SPERMATOZOON MOTILITY; VAGINA CONTRACEPTION; VAGINA MUCOSA;

ACROSOME REACTION; ANIMALS; ANTI-HIV AGENTS; CELL MEMBRANE; CERVIX UTERI; DRUG EVALUATION, PRECLINICAL; EMULSIONS; EPITHELIAL CELLS; FEMALE; HIV-1; HUMANS; MALE; RABBITS; SPERM MOTILITY; SPERMATOCIDAL AGENTS; SPERMATOZOA; THYMIDINE MONOPHOSPHATE; VAGINA; VIRUS REPLICATION; ZIDOVUDINE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS;

EID: 0032935520     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/5.5.421     Document Type: Article

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