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Volumn 62, Issue 1, 2000, Pages 37-44

Structural requirements for potent human spermicidal activity of dual- function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI- 07)

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 5,6 DIHYDRO 6 METHOXY 3' AZIDOTHYMIDINE 5' (4 BROMOPHENYL)METHOXYALANINYL PHOSPHATE; NONOXINOL 9; SPERMICIDAL AGENT; UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE;

EID: 0033970759     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod62.1.37     Document Type: Article
Times cited : (43)

References (44)
  • 2
    • 0030582188 scopus 로고    scopus 로고
    • Global burden of the HIV epidemic
    • Quinn TC. Global burden of the HIV epidemic. Lancet 1996; 348: 99-106.
    • (1996) Lancet , vol.348 , pp. 99-106
    • Quinn, T.C.1
  • 3
    • 0031602639 scopus 로고    scopus 로고
    • Preventive interventions to reduce heterosexual HIV risk for women: Current perspectives, future directions
    • Ickovics JR, Yoshikawa H. Preventive interventions to reduce heterosexual HIV risk for women: current perspectives, future directions. AIDS 1998; 12(suppl A):S197-208.
    • (1998) AIDS , vol.12 , Issue.SUPPL. A
    • Ickovics, J.R.1    Yoshikawa, H.2
  • 4
    • 0342742579 scopus 로고    scopus 로고
    • HIV and women
    • Spach DH, Hooten TM (eds.), New York: Oxford University Press
    • Celum CL, Watts DH. HIV and women. In: Spach DH, Hooten TM (eds.), The HIV Manual. New York: Oxford University Press; 1996: 120-127.
    • (1996) The HIV Manual , pp. 120-127
    • Celum, C.L.1    Watts, D.H.2
  • 5
    • 0030635035 scopus 로고    scopus 로고
    • The epidemiology of HIV and AIDS in the United States
    • Ward JW, Duchin JS. The epidemiology of HIV and AIDS in the United States. AIDS Clin Rev 1997; 98:1-45.
    • (1997) AIDS Clin Rev , vol.98 , pp. 1-45
    • Ward, J.W.1    Duchin, J.S.2
  • 6
    • 0003185311 scopus 로고    scopus 로고
    • US HIV and AIDS cases reported through december 1996
    • CDCP Update. US HIV and AIDS cases reported through December 1996. HIV/AIDS Surveillance Report 1997; 8:1-33.
    • (1997) HIV/AIDS Surveillance Report , vol.8 , pp. 1-33
  • 8
    • 0029819867 scopus 로고    scopus 로고
    • HIV infection in women: An escalating health concern
    • Sallio SD, Kurtzman JT, Radner AB. HIV infection in women: an escalating health concern. Am Fam Phys 1996; 54:1541-1548.
    • (1996) Am Fam Phys , vol.54 , pp. 1541-1548
    • Sallio, S.D.1    Kurtzman, J.T.2    Radner, A.B.3
  • 9
    • 0030589850 scopus 로고    scopus 로고
    • Mortality attributable to HIV infection among persons aged 25-44 years - United States, 1994
    • CDCP Update. Mortality attributable to HIV infection among persons aged 25-44 years - United States, 1994. MMWR 1996; 45:121-125.
    • (1996) MMWR , vol.45 , pp. 121-125
  • 10
    • 0027925132 scopus 로고
    • Boost for vaginal microbicides against HIV
    • Lange JMA, Karam M, Piot P. Boost for vaginal microbicides against HIV. Lancet 1993; 341:1356-1359.
    • (1993) Lancet , vol.341 , pp. 1356-1359
    • Lange, J.M.A.1    Karam, M.2    Piot, P.3
  • 11
    • 0027925109 scopus 로고
    • WHO to concentrate HIV strategy on vaginal microbicide
    • Cookson C. WHO to concentrate HIV strategy on vaginal microbicide. Br Med J 1993; 307:1375-1376.
    • (1993) Br Med J , vol.307 , pp. 1375-1376
    • Cookson, C.1
  • 12
    • 0028219733 scopus 로고
    • Challenges for the development of female-controlled vaginal microbicides
    • Elias CJ, Heise LL. Challenges for the development of female-controlled vaginal microbicides. AIDS 1994; 8:1-9.
    • (1994) AIDS , vol.8 , pp. 1-9
    • Elias, C.J.1    Heise, L.L.2
  • 13
    • 0027982312 scopus 로고
    • The urgent need for a vaginal microbicide in the prevention of HIV transmission
    • Editorial
    • Potts M. The urgent need for a vaginal microbicide in the prevention of HIV transmission. Am J Public Health 1994; 84:890-891 [Editorial].
    • (1994) Am J Public Health , vol.84 , pp. 890-891
    • Potts, M.1
  • 14
    • 0029946095 scopus 로고    scopus 로고
    • Epidemiology of HIV infection in women and newborns
    • Gwinn M, Wortley PM. Epidemiology of HIV infection in women and newborns. Clin Obstet Gynecol 1996; 39:293-304.
    • (1996) Clin Obstet Gynecol , vol.39 , pp. 293-304
    • Gwinn, M.1    Wortley, P.M.2
  • 15
    • 0026514158 scopus 로고
    • Vaginal contraception: Some current concerns
    • Chantler E. Vaginal contraception: some current concerns. Br J Fam Plann 1992; 17:118-119.
    • (1992) Br J Fam Plann , vol.17 , pp. 118-119
    • Chantler, E.1
  • 16
    • 0000040227 scopus 로고
    • Vaginal contraceptive drug products for over-the-counter human use
    • OTC Panel. Vaginal contraceptive drug products for over-the-counter human use. Fed Reg 1980; 45:82014-82049.
    • (1980) Fed Reg , vol.45 , pp. 82014-82049
  • 17
    • 0026576056 scopus 로고
    • The toxicity and local effects of the spermicide nonoxynol-9
    • Rekart ML. The toxicity and local effects of the spermicide nonoxynol-9. J Acquired Immune Defic Syndr 1992; 5:425-427.
    • (1992) J Acquired Immune Defic Syndr , vol.5 , pp. 425-427
    • Rekart, M.L.1
  • 20
    • 0031924987 scopus 로고    scopus 로고
    • Effect of normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1
    • Rosenstein IJ, Stafford MK, Kitchen VS, Ward H, Weber JN, Taylor-Robinson D. Effect of normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1. J Infect Dis 1998; 177:1386-1390.
    • (1998) J Infect Dis , vol.177 , pp. 1386-1390
    • Rosenstein, I.J.1    Stafford, M.K.2    Kitchen, V.S.3    Ward, H.4    Weber, J.N.5    Taylor-Robinson, D.6
  • 23
    • 0028901558 scopus 로고
    • Nonoxynol-9 use, genital ulcers, and HIV infection in a cohort of sex workers
    • Weir SS, Roddy RE, Zeking L, Feldblum PJ. Nonoxynol-9 use, genital ulcers, and HIV infection in a cohort of sex workers. Genitourin Med 1995; 71:78-81.
    • (1995) Genitourin Med , vol.71 , pp. 78-81
    • Weir, S.S.1    Roddy, R.E.2    Zeking, L.3    Feldblum, P.J.4
  • 24
    • 0019420083 scopus 로고
    • Ultrastructure of human spermatozoa in the presence of the spermicide nonoxynol-9 and a vaginal contraceptive containing nonoxynol-9
    • Schill WB, Wolf HH. Ultrastructure of human spermatozoa in the presence of the spermicide nonoxynol-9 and a vaginal contraceptive containing nonoxynol-9. Andrologia 1981; 13:42-49.
    • (1981) Andrologia , vol.13 , pp. 42-49
    • Schill, W.B.1    Wolf, H.H.2
  • 25
    • 0020622026 scopus 로고
    • Scanning electron microscopy of human spermatozoa after incubation with the spermicide nonoxynol-9
    • Wilborn WH, Hahn DW, McGuire JJ. Scanning electron microscopy of human spermatozoa after incubation with the spermicide nonoxynol-9. Fertil Steril 1983; 39:717-719.
    • (1983) Fertil Steril , vol.39 , pp. 717-719
    • Wilborn, W.H.1    Hahn, D.W.2    McGuire, J.J.3
  • 26
    • 0029933108 scopus 로고    scopus 로고
    • Efficacy of nonoxynol-9 from an in vitro point of view
    • Bourinbaiar AS, Fruhstorfer EC. Efficacy of nonoxynol-9 from an in vitro point of view. AIDS 1996; 10:558-559.
    • (1996) AIDS , vol.10 , pp. 558-559
    • Bourinbaiar, A.S.1    Fruhstorfer, E.C.2
  • 27
    • 0031822196 scopus 로고    scopus 로고
    • The protective effect of condoms and nonoxynol-9 against HIV infection
    • Wittkowiski KM, Susser E, Dietz K. The protective effect of condoms and nonoxynol-9 against HIV infection. Am J Public Health 1998; 88:590-596.
    • (1998) Am J Public Health , vol.88 , pp. 590-596
    • Wittkowiski, K.M.1    Susser, E.2    Dietz, K.3
  • 28
    • 0030942129 scopus 로고    scopus 로고
    • Condom and nonoxynol-9 use and the incidence of HIV infection in serodiscordant coupLes in zambia
    • Hira SK, Feldblum PJ, Kamanga J, Mukelabai G, Weir SS, Thomas JC. Condom and nonoxynol-9 use and the incidence of HIV infection in serodiscordant couples in Zambia. Int J STD AIDS 1997; 8:243-250.
    • (1997) Int J STD AIDS , vol.8 , pp. 243-250
    • Hira, S.K.1    Feldblum, P.J.2    Kamanga, J.3    Mukelabai, G.4    Weir, S.S.5    Thomas, J.C.6
  • 29
    • 0032552228 scopus 로고    scopus 로고
    • A controlled trial of nonoxynol-9 film to reduce male-to-female transmission of sexually transmitted diseases
    • Roddy RE, Zeking L, Ryan KA, Tamoufe U, Weir SS, Wong EL. A controlled trial of nonoxynol-9 film to reduce male-to-female transmission of sexually transmitted diseases. N Engl J Med 1998; 339: 504-510.
    • (1998) N Engl J Med , vol.339 , pp. 504-510
    • Roddy, R.E.1    Zeking, L.2    Ryan, K.A.3    Tamoufe, U.4    Weir, S.S.5    Wong, E.L.6
  • 30
    • 0028233744 scopus 로고
    • The role of cell-to-cell transmission in HIV infection
    • Phillips DM. The role of cell-to-cell transmission in HIV infection. AIDS 1994; 8:719-731.
    • (1994) AIDS , vol.8 , pp. 719-731
    • Phillips, D.M.1
  • 31
    • 0030863628 scopus 로고    scopus 로고
    • T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen
    • Quayle AJ, Xu C, Mayer KH, Anderson DJ. T Lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen. J Infect Dis 1997; 176:960-968.
    • (1997) J Infect Dis , vol.176 , pp. 960-968
    • Quayle, A.J.1    Xu, C.2    Mayer, K.H.3    Anderson, D.J.4
  • 33
    • 0031826304 scopus 로고    scopus 로고
    • Bromomethoxy and aryl phosphate derivatives of azidothymidine are dual-function spermicides with potent anti-HIV activity
    • D'Cruz OJ, Venkatachalam TK, Zhu Z, Shih M-J, Uckun FM. Bromomethoxy and aryl phosphate derivatives of azidothymidine are dual-function spermicides with potent anti-HIV activity. Biol Reprod 1998; 59:503-515.
    • (1998) Biol Reprod , vol.59 , pp. 503-515
    • D'Cruz, O.J.1    Venkatachalam, T.K.2    Zhu, Z.3    Shih, M.-J.4    Uckun, F.M.5
  • 34
    • 0033055611 scopus 로고    scopus 로고
    • AZT-5′-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent
    • Jan ST, Zhu Z, Tai HL, Shih MJ, Venkatachalam TK, Uckun FM. AZT-5′-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent. Antivir Chem Chemother 1999; 10:47-52.
    • (1999) Antivir Chem Chemother , vol.10 , pp. 47-52
    • Jan, S.T.1    Zhu, Z.2    Tai, H.L.3    Shih, M.J.4    Venkatachalam, T.K.5    Uckun, F.M.6
  • 35
    • 0033056262 scopus 로고    scopus 로고
    • Synthesis of dual-function (5R,6R)-and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5′-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents
    • Jan S-T, Shih M-J, Venkatachalam TK, D'Cruz OJ, Chen C-L, Uckun FM. Synthesis of dual-function (5R,6R)-and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5′-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents. Antivir Chem Chemother 1999; 10:39-46.
    • (1999) Antivir Chem Chemother , vol.10 , pp. 39-46
    • Jan, S.-T.1    Shih, M.-J.2    Venkatachalam, T.K.3    D'Cruz, O.J.4    Chen, C.-L.5    Uckun, F.M.6
  • 36
    • 0032935520 scopus 로고    scopus 로고
    • Synthesis, characterization, and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities
    • D'Cruz OJ, Shih M-J, Yiv SH, Chen C-L, Uckun FM. Synthesis, characterization, and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities. Mol Hum Reprod 1999; 5:421-432.
    • (1999) Mol Hum Reprod , vol.5 , pp. 421-432
    • D'Cruz, O.J.1    Shih, M.-J.2    Yiv, S.H.3    Chen, C.-L.4    Uckun, F.M.5
  • 37
    • 0032856030 scopus 로고    scopus 로고
    • WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity
    • D'Cruz OJ, Zhu Z, Yiv SH, Chen C-L, Waurzyniak B, Uckun FM. WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity. Contraception 1999; 59:319-331.
    • (1999) Contraception , vol.59 , pp. 319-331
    • D'Cruz, O.J.1    Zhu, Z.2    Yiv, S.H.3    Chen, C.-L.4    Waurzyniak, B.5    Uckun, F.M.6
  • 38
    • 0033004764 scopus 로고    scopus 로고
    • Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-HIV activity
    • D'Cruz OJ, Uckun FM. Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-HIV activity. Biol Reprod 1999; 60: 1419-1428.
    • (1999) Biol Reprod , vol.60 , pp. 1419-1428
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 39
    • 0028971538 scopus 로고
    • Integrin (CD11b/CD18) is the primary adhesive glycoprotein complex involved in neutrophil-mediated immune injury to human sperm
    • 2-Integrin (CD11b/CD18) is the primary adhesive glycoprotein complex involved in neutrophil-mediated immune injury to human sperm. Biol Reprod 1995; 53:1118-1130.
    • (1995) Biol Reprod , vol.53 , pp. 1118-1130
    • D'Cruz, O.J.1    Haas G.G., Jr.2
  • 40
    • 0031810656 scopus 로고    scopus 로고
    • Spermicidal activity of metallocene complexes containing vanadium(IV) in humans
    • D'Cruz OJ, Ghosh P, Uckun FM. Spermicidal activity of metallocene complexes containing vanadium(IV) in humans. Biol Reprod 1998; 58:1515-1526.
    • (1998) Biol Reprod , vol.58 , pp. 1515-1526
    • D'Cruz, O.J.1    Ghosh, P.2    Uckun, F.M.3
  • 41
    • 0031823092 scopus 로고    scopus 로고
    • Spermicidal activity of chelated complexes of bis cyclopentadienyl vanadium complexes
    • D'Cruz OJ, Ghosh P, Uckun FM. Spermicidal activity of chelated complexes of bis cyclopentadienyl vanadium complexes. Mol Hum Reprod 1998; 4:683-693.
    • (1998) Mol Hum Reprod , vol.4 , pp. 683-693
    • D'Cruz, O.J.1    Ghosh, P.2    Uckun, F.M.3
  • 42
    • 0032928158 scopus 로고    scopus 로고
    • Spermicidal activity of oxovanadium(IV) complexes of 1,10-phenanthroline, 2,2′-bipyridyl, 5′-bromo-2′-hydroxyacetophenone and derivatives in humans
    • D'Cruz OJ, Dong Y, Uckun FM. Spermicidal activity of oxovanadium(IV) complexes of 1,10-phenanthroline, 2,2′-bipyridyl, 5′-bromo-2′-hydroxyacetophenone and derivatives in humans. Biol Reprod 1999; 60:435-444.
    • (1999) Biol Reprod , vol.60 , pp. 435-444
    • D'Cruz, O.J.1    Dong, Y.2    Uckun, F.M.3


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