Common alterations in PBP1a from resistant Streptococcus pneumoniae decrease its reactivity toward β-lactams: Structural insights

Journal of Biological Chemistry

Volumn 283, Issue 8, 2008, Pages 4886-4894

  Job, Viviana ^a   Carapito, Raphaël ^a   Vernet, Thierry ^a   Dessen, Andréa ^a   Zapun, André ^a,b  

^a CEA GRENOBLE   (France)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; REACTION KINETICS;

ACTIVE SITES; CATALYTIC NUCLEOPHILES; CEFOTAXIME; IN VITRO; IN-VIVO; MINIMAL INHIBITORY CONCENTRATIONS; ON RESISTANCES; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL INSIGHTS;

CRYSTAL STRUCTURE;

CEFOTAXIME; PENICILLIN BINDING PROTEIN; PENICILLIN G; PROTEIN PBP1A; SERINE; UNCLASSIFIED DRUG; AMINOACYLTRANSFERASE; BACTERIAL PROTEIN; BETA LACTAM; PBP 2X PROTEIN, STREPTOCOCCUS; PBP1A PROTEIN, STREPTOCOCCUS PNEUMONIAE; PENICILLIN BINDING PROTEIN 2B, STREPTOCOCCUS; PENICILLIN-BINDING PROTEIN 2B, STREPTOCOCCUS; PEPTIDYLTRANSFERASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS PNEUMONIAE; SUBSTITUTION REACTION; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SUBSTITUTION; AMINOACYLTRANSFERASES; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; KINETICS; MUTATION, MISSENSE; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PROTEIN STRUCTURE, TERTIARY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41949112411     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706181200     Document Type: Article

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