Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for β-lactam antibiotics

Journal of Biological Chemistry

Volumn 274, Issue 27, 1999, Pages 19175-19180

  Mouz, Nicolas ^a   Di Guilmi, Anne Marie ^a   Gordon, Elspeth ^a   Hakenbeck, Regine ^b   Dideberg, Otto ^a   Vernet, Thierry ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b University of Koblenz Landau   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BETA LACTAM ANTIBIOTIC; CEFALOTIN; CEFOTAXIME; CEFPODOXIME; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; GLUTAMIC ACID; GLUTAMINE; PENICILLIN BINDING PROTEIN; PENICILLIN G; THIOESTER; THREONINE;

ACYLATION; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENETIC RESISTANCE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PROTEIN TERTIARY STRUCTURE; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE CHARGE;

ACYLATION; BINDING SITES; CARRIER PROTEINS; CEFUROXIME; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PENICILLIN G; PENICILLIN RESISTANCE; PENICILLIN-BINDING PROTEINS; PROTEIN STRUCTURE, SECONDARY; STREPTOCOCCUS PNEUMONIAE;

ESCHERICHIA COLI; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 0033516564     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.27.19175     Document Type: Article

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