β-lactam resistance in Streptococcus pneumoniae: Penicillin-binding proteins and non-penicillin-binding proteins

Molecular Microbiology

Volumn 33, Issue 4, 1999, Pages 673-678

  Hakenbeck, Regine ^a   Grebe, Thorsten ^b   Zähner, Dorothea ^a   Stock, Jeffry B ^b  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; GLYCOSYLTRANSFERASE; PENICILLIN BINDING PROTEIN; PROTEIN KINASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIUM MUTANT; GENE TRANSFER; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CARRIER PROTEINS; GLYCOSYLTRANSFERASES; HEXOSYLTRANSFERASES; MODELS, MOLECULAR; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTATION; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PROTEIN KINASES; STREPTOCOCCUS PNEUMONIAE;

EID: 0032815561     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01521.x     Document Type: Article

References (30)

1. Arthur, M., Molinas, C., and Courvalin, P. (1992) The VanS-VanR two component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol 174: 2582-2591.
2. Ayala, J.A., Garrido, T., De Pedro, M.A., and Vicente, M. (1994) Molecular biology of bacterial septation. In Bacterial Cell Wall. Ghuysen, J.-M., and Hakenbeck, R. (eds). Amsterdam: Elsevier, pp. 73-101.
3. Dowson, C.G., Coffey, T.J., Kell, C., and Whiley, R.A. (1993) Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2B in S Pneumoniae. Mol Microbiol 9: 635-643.
4. Goffin, C., and Ghuysen, J.-M. (1998) Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Microb Mol Biol Rev 62: 1079-1093.
5. Grebe, T., and Hakenbeck, R. (1996) Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of β-lactam antibiotics. Antimicrob Agents Chemother 40: 829-834.
6. Grebe, T., and Stock, J.B. (1999) The histidine kinase superfamily. Adv Microb Phys 41 (in press).
7. Grebe, T., Paik, J., and Hakenbeck, R. (1997) A novel resistance mechanism for β-lactams in Streptococcus pneumoniae involves CpoA, a putative glycosyltransferases. J Bacteriol 179: 3342-3349.
8. Guenzi, E., Gasc, A.M., Sicard, M.A., and Hakenbeck, R. (1994) A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol Microbiol 12: 505-515.
9. Hacker, J., Blum-Ohler, G., Mühldorfer, I., and Tschäpe, H. (1997) Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution. Mol Microbiol 23: 1089-1097.
10. Hakenbeck, R. (1997) Mosaic genes and their role in penicillin resistant Streptococcus pneumoniae. Electrophoresis 19: 597-601.
11. Hakenbeck, R., and Coyette, J. (1998) Resistant penicillin-binding proteins. Cell Mol Life Sci 54: 332-340.
12. Hakenbeck, R., Tornette, S., and Adkinson, N.F. (1987) Interaction of non-lytic β-lactams with penicillin-binding proteins in Streptococcus pneumoniae. J Gen Microbiol 133: 755-760.
13. r penicillin-binding protein variants during transfer of high-level β-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae. J Bacteriol 180: 1831-1840.
14. Håvarstein, L.S., Coomaraswamy, G., and Morrison, D.A. (1995) An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc Natl Acad Sci USA 92: 11140-11144.
15. Håvarstein, L.S., Gaustad, P., Nes, I.F., and Morrison, D.A. (1996) Identification of the streptococcal competence-pheromone receptor. Mol Microbiol 21: 863-869.
16. Håvarstein, L.S., Hakenbeck, R., and Gaustad, P. (1997) Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchanges. J Bacteriol 179: 6589-6594.
17. Höltje, J.-V., and Tomasz, A. (1976) Purification of the pneumococcal N-acetylmuramyl-L-alanie amidase to biochemical homogeneity. J Biol Chem 251: 4199-4207.
18. Kell, C.M., Sharma, U.K., Dowson, C.G., Town, C., Balganesh, T.S., and Spratt, B.G. (1993) Deletion analysis of the essentiality of penicillin-binding proteins 1A, 2B and 2X of Streptococcus pneumoniae. FEMS Microbiol Lett 106: 171-175.
19. Laible, G., and Hakenbeck, R. (1987) Penicillin-binding proteins in β-lactam-resistant laboratory mutants of Streptococcus pneumoniae. Mol Microbiol 1: 355-363.
20. Laible, G., and Hakenbeck, R. (1991) Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae. J Bacteriol 173: 6986-6990.
21. Liu, H.H., and Tomasz, A. (1985) Penicillin tolerance in multiply drug-resistant natural isolates of Streptococcus pneumoniae. J Infect Dis 152: 365-372.
22. Moreillon, P., Markiewicz, Z., Nachman, S., and Tomasz, A. (1990) Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms. Antimicrob Agents Chemother 34: 33-39.
23. Mueller, F., Döring, T., Erdemir, T., Greuer, B., Jünke, N., Osswald, M., et al. (1995) Getting closer to an understanding of the three-dimensional structure of the ribosomal RNA. Biochem Cell Biol 73: 767-773.
24. Muñóz, R., Dowson, C.G., Daniels, M., Coffey, T.J., Martin, C., Hakenbeck, R., and Spratt, B.G. (1992) Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol Microbiol 6: 2461-2465.
25. Pares, S., Mouz, N., Pétillot, Y., Hakenbeck, R., and Dideberg, O. (1996) X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Nature Struct Biol 3: 284-289.
26. Pestova, E.V., Håvarstein, L.S., and Morrison, D.A. (1996) Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system. Mol Microbiol 21: 853-862.
27. Ramirez, M., Morrison, D.A., and Tomasz, A. (1997) Ubiquitous distribution of the competence related genes comA and comC among isolates of Streptococcus pneumoniae. Microb Drug Resist 3: 39-52.
28. Reichmann, P., König, A., Liñares, J., Alcaide, F., Tenover, F.C., McDougal, L., et al. (1997) A global gene pool for high-level cephalosporin resistance in commensal Streptococcus spp. and Streptococcus pneumoniae. J Infect Dis 176: 1001-1012.
29. Sibold, C., Henrichsen, J., König, A., Martin, C., Chalkley, L., and Hakenbeck, R. (1994) Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis. Mol Microbiol 12: 1013-1023.
30. Tuomanen, E., Pollack, H., Parkinson, A., Davidson, M., Facklam, R., Rich, R., and Zak, O. (1988) Microbiological and clinical insignificance of a new property of defective lysis in clinical strains of pneumococci. J Infect Dis 158: 36-43.