A PBP2x from a Clinical Isolate of Streptococcus pneumoniae Exhibits an Alternative Mechanism for Reduction of Susceptibility to β-Lactam Antibiotics

Journal of Biological Chemistry

Volumn 279, Issue 16, 2004, Pages 16463-16470

  Pernot, Lucile ^a   Chesnel, Laurent ^a   Le Gouellec, Audrey ^a   Croizé, Jacques ^b   Vernet, Thierry ^a   Dideberg, Otro ^a   Dessen, Andréa ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CONFORMATIONS; DRUG PRODUCTS; MUTAGENESIS; PROTEINS;

DRUG SENSITIVE STRAINS; RESPIRATORY TRACT INFECTIONS;

BIOCHEMISTRY;

BETA LACTAM ANTIBIOTIC; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 2X; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM TRANSFORMATION; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA ANALYSIS; DRUG SENSITIVITY; MUTATION; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ANALYSIS;

BETA-LACTAM RESISTANCE; BINDING SITES; CARRIER PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PENICILLIN-BINDING PROTEINS; PROTEIN CONFORMATION; RIBONUCLEOPROTEINS; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 1942437430     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313492200     Document Type: Article

References (42)

1. Appelbaum, P. C. (2002) Clin. Infect. Dis. 34, 1613-1620
2. McCormick, A. W., Whitney, C. G., Farley, M. M., Lynfield, R., Harrison, L. H., Bennett, N. M., Schaffner, W., Reingold, A., Hadler, J., Cieslak, P., Samore, M. H., and Lipsitch, M. (2003) Nat. Med. 9, 424-430
3. Holtje, J. V. (1998) Microbiol. Mol. Biol. Rev. 62, 181-203
4. van Heijenoort, J. (1998) Cell Mol. Life Sci. 54, 300-304
5. Ghuysen, J. M. (1994) Trends Microbiol. 2, 372-380
6. Di Guilmi, A. M., Dessen, A., Dideberg, O., and Vernet, T. (2003) J. Bacteriol. 185, 4418-4423
7. Hakenbeck, R., Briese, T., and Ellerbrok, H. (1986) Eur. J. Biochem. 157, 101-106
8. Ghuysen, J. M. (1991) Annu. Rev. Microbiol. 45, 37-67
9. Jamin, M., Damblon, C., Millier, S., Hakenbeck, R., and Frère, J. M. (1993) Biochem. J. 292, 735-741
10. Waxman, D. J., and Strominger, J. L. (1983)Annu. Rev. Biochem. 52, 825-869
11. Coffey, T. J., Dowson, C. G., Daniels, M., Zhou, J., Martin, C., Spratt, B. G., and Musser, J. M. (1991) Mol. Microbiol. 5, 2255-2260
12. du Plessis, M., Bingen, E., and Klugman, K. P. (2002) Antimicrob. Agents Chemother. 46, 2349-2357
13. Nagai, K., Davies, T. A., Jacobs, M. R., and Appelbaum, P. C. (2002) Antimicrob. Agents Chemother. 46, 1273-1280
14. Asahi, Y., Takeuchi, Y., and Ubukata, K. (1999) Antimicrob. Agents Chemother. 43, 1252-1255
15. Laible, G., and Hakenbeck, R. (1991) J. Bacteriol. 173, 6986-6990
16. Grebe, T., and Hakenbeck, R. (1996) Antimicrob. Agents Chemother. 40, 829-834
17. Laible, G., Spratt, B. G., and Hakenbeck, R. (1991) Mol. Microbiol. 5, 1993-2002
18. Hoskins, J., Alborn, W. E., Jr., Arnold, J., Blaszczak, L. C., Burgett, S., DeHoff, B. S., Estrem, S. T., Fritz, L., Fu, D. J., Fuller, W., Geringer, C., Gilmour, R., Glass, J. S., Khoja, H., Kraft, A. R., Lagace, R. E., LeBlanc, D. J., Lee, L. N., Lefkowitz, E. J., Lu, J., Matsushima, P., McAhren, S. M., McHenney, M., McLeaster, K., Mundy, C. W., Nicas, T. I., Norris, F. H., O'Gara, M., Peery, R. B., Robertson, G. T., Rockey, P., Sun, P. M., Winkler, M. E., Yang, Y., Young-Bellido, M., Zhao, G., Zook, C. A., Baltz, R. H., Jaskunas, S. R., Rosteck, P. R., Jr., Skatrud, P. L., and Glass, J. I. (2001) J. Bacteriol. 183, 5709-5717
19. Zhao, G., Yeh, W. K., Carnahan, R. H., Flokowitsch, J., Meier, T. I., Alborn, W. E., Jr., Becker, G. W., and Jaskunas, S. R. (1997) J. Bacteriol. 179, 4901-4908
20. Krauss, J., van der Linden, M., Grebe, T., and Hakenbeck, R. (1996) Microb. Drug Resist. 2, 183-186
21. Thomas, B., Wang, Y., and Stein, R. L. (2001) Biochemistry 40, 15811-15823
22. Gordon, E., Mouz, N., Duée, E., and Dideberg, O. (2000) J. Mol. Biol. 299, 477-485
23. Dessen, A., Mouz, N., Gordon, E., Hopkins, J., and Dideberg, O. (2001) J. Biol. Chem. 276, 45106-45112
24. Parès, S., Mouz, N., Petillot, Y., Hakenbeck, R., and Dideberg, O. (1996) Nat. Struct. Biol. 3, 284-289
25. Mouz, N., Di Guilmi, A. M., Gordon, E., Hakenbeck, R., Dideberg, O., and Vernet, T. (1999) J. Biol. Chem. 274, 19175-19180
26. Mouz, N., Gordon, E., Di Guilmi, A. M., Petit, I., Petillot, Y., Dupont, Y., Hakenbeck, R., Vernet, T., and Dideberg, O. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13403-13406
27. Chesnel, L., Pernot, L., Lemaire, D., Champelovier, D., Croizé, J., Dideberg, O., Vernet, T., and Zapun, A. (2003) J. Biol. Chem. 278, 44448-44456
28. Di Guilmi, A. M., Mouz, N., Petillot, Y., Forest, E., Dideberg, O., and Vernet, T. (2000) Anal. Biochem. 284, 240-246
29. Leslie, A. G. (1999) Acta Crystallogr. Sect. D 55, 1696-1702
30. CCP4 (1994) Acta Crystallogr. Sect. D 50, 760-766
31. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 157-163
32. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
33. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard. (1991) Acta Crystallogr. Sect. A 47, 110-119
34. Brunger, A. T. (1992) Nature 355, 472-475
35. Laskowski, R., MacArthur, M., Moss, D., and Thornton, J. (1993) J. Appl. Crystallogr. 26, 283-291
36. Frère, J. M., Ghuysen, J. M., and Iwatsubo, M. (1975) Eur. J. Biochem. 57, 343-351
37. Lim, D., and Strynadka, N. C. (2002) Nat. Struct. Biol. 9, 870-876
38. Hakenbeck, R., Balmelle, N., Weber, B., Gardes, C., Keck, W., and de Saizieu, A. (2001) Infect Immun. 69, 2477-2486
39. Lu, W. P., Kincaid, E., Sun, Y., and Bauer, M. D. (2001) J. Biol. Chem. 276, 31494-31501
40. Sauvage, E., Kerff, F., Fonze, E., Herman, R., Schoot, B., Marquette, J. P., Taburet, Y., Prevost, D., Dumas, J., Leonard, G., Stefanic, P., Coyette, J., and Charlier, P. (2002) Cell Mol. Life Sci. 59, 1223-1232
41. Kraulis, P. (1991) J. Appl. Crystallogr. 24, 946-950
42. Merrit, E. A., and Murphy, M. E. (1994) Acta Crystallogr. Sect. D 50, 869-873