Penicillin-binding proteins as resistance determinants in clinical isolates of Streptococcus pneumoniae

Microbial Drug Resistance

Volumn 2, Issue 2, 1996, Pages 177-181

  Reichmann, Peter ^a   König, Andrea ^a   Marton, Anna ^b   Hakenbeck, Regine ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b National Institute of Public Health Budapest   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CHLORAMPHENICOL; DNA; OXACILLIN; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

EID: 0029904121     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.1996.2.177     Document Type: Article

References (19)

1. Avery, O.T., C.M. MacLeod, and M. McCarty. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. J. Exp. Med. 79:137-158.
2. Dowson, C.G., A. Hutchison, J.A. Brannigan, R.C. George, D. Hansman, J. Liñares, A. Tomasz, J.M. Smith, and B.G. Spratt. 1989. Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc. Natl. Acad. Sci. U.S.A. 86:8842-8846.
3. Dowson, C.G., A. Hutchison, and B.G. Spratt. 1989. Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae. Nucl. Acids Res. 17:7518.
4. Grebe, T., and Hakenbeck, R. 1996. Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of β-lactam antibiotics. Antimicrob. Agents Chemother. 40:829-834.
5. Hakenbeck, R. 1995. Target mediated resistance to β-lactam antibiotics. Biochem. Pharmacol. 50:1121-1127.
6. Hakenbeck, R., T. Briese, L. Chalkley, H. Ellerbrok, R. Kalliokoski, C. Latorre, M. Leinonen, and C. Martin. 1991. Antigenic variation of penicillin-binding proteins from penicillin resistant clinical strains of Streptococcus pneumoniae. J. Infect. Dis. 164:313-319.
7. Hakenbeck, R., S. Tornette, and N.F. Adkinson. 1987. Interaction of non-lytic β-lactams with penicillin-binding proteins in Streptococcus pneumoniae. J. Gen. Microbiol. 133:755-760.
8. Lacks, S.A., and R.D. Hotchkiss. 1960. A study of the genetic material determining an enzyme activity in pneumococcus. Biochim. Biophys. Acta 39:508-517.
9. Laible, G., R. Hakenbeck, M.A. Sicard, B. Joris, and J.-M. Ghuysen. 1989. Nucleotide sequences of the pbpX genes encoding the penicillin-binding protein 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506. Mol. Microbiol. 3:1337-1348.
10. Laible, G., B.G. Spratt, and R. Hakenbeck. 1991. Inter-species recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Mol. Microbiol. 5:1993-2002.
11. Martin, C., T. Briese, and R. Hakenbeck. 1992. Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding protein 1A and 1B. J. Bacteriol. 174:4517-4523.
12. Martin, C., C. Sibold, and R. Hakenbeck. 1992. Relatedness of penicillin-binding protein la genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain. EMBO J. 11:3831-3836.
13. Muñóz, R., C. G. Dowson, M. Daniels, TJ. Coffey, C. Martin, R. Hakenbeck, and B.G. Spratt. 1992. Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol. Microbiol. 6:2461-2465.
14. Reichmann, P., E. Varon, E. Günther, R.R. Reinert, R. Lütticken, A. Marton, P. Geslin, J. Wagner, and R. Hakenbeck. 1995. Penicillin-resistant Streptococcus pneumoniae in Germany: Genetic relationship to clones from other European countries. J. Med. Microbiol. 43:377-385.
15. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. U.S.A. 74:5463-5467.
16. Sibold, C., J. Henrichsen, A. König, C. Martin, L. Chalkley, and R. Hakenbeck. 1994. Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis. Mol. Microbiol. 12:1013-1023.
17. Sibold, C., J. Wang, J. Henrichsen, and R. Hakenbeck. 1992. Genetic relationship on penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different containent. Infect. Immun. 60:4119-4126.
18. Spratt, B.G. 1994. Resistance to β-lactam antibiotics, pp. 517-534. In J.-M. Ghuysen and R. Hakenbeck (eds.). Bacterial cell wall. Elsevier Science, B.V. Amsterdam.
19. Tiraby, J.-G., and M.S. Fox. 1974. Marker discrimination and mutagen-induced alterations in pneumococcal transformation. Genetics 77:449-458.