Kinetics of β-lactam interactions with penicillin-susceptible and -resistant penicillin-binding protein 2x proteins from Streptococcus pneumoniae. Involvement of acylation and deacylation β-lactam resistance

Journal of Biological Chemistry

Volumn 276, Issue 34, 2001, Pages 31494-31501

  Lu, Wei Ping ^a   Kincaid, Erica ^a   Sun, Yiping ^b   Bauer, Mark D ^b  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; ANTIBIOTICS; MASS SPECTROMETRY; PROTEINS; RATE CONSTANTS;

DEACYLATION;

BIOCHEMISTRY;

BETA LACTAM ANTIBIOTIC; CEFOTAXIME; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 2X; PENICILLIN G; UNCLASSIFIED DRUG; BETA LACTAM; CARRIER PROTEIN; PBP 2X PROTEIN, STREPTOCOCCUS;

ACYLATION; ARTICLE; BINDING AFFINITY; DEACYLATION; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; EXPRESSION VECTOR; MASS SPECTROMETRY; MOLECULAR CLONING; NONHUMAN; PENICILLIN RESISTANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; ANTIBIOTIC RESISTANCE; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR WEIGHT; PROTEIN BINDING;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE; VECTORS;

ACYLATION; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CARRIER PROTEINS; CLONING, MOLECULAR; KINETICS; MOLECULAR WEIGHT; PENICILLIN-BINDING PROTEINS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STREPTOCOCCUS PNEUMONIAE;

EID: 0035943720     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102499200     Document Type: Article

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