-
1
-
-
0000463651
-
The structural and mechanical complexity of cell-growth control
-
Huang S, Ingber DE. The structural and mechanical complexity of cell-growth control. Nat Cell Biol 1999; 1:E131-E138.
-
(1999)
Nat Cell Biol
, vol.1
-
-
Huang, S.1
Ingber, D.E.2
-
2
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21:247-269.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
3
-
-
0024315634
-
Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: Role of extracellular matrix
-
Ingber DE, Folkman J. Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol 1989; 109:317-330.
-
(1989)
J Cell Biol
, vol.109
, pp. 317-330
-
-
Ingber, D.E.1
Folkman, J.2
-
4
-
-
33847678638
-
Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation
-
Chen SS, Fitzgerald W, Zimmerberg J, et al. Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation. Stem Cells 2007; 25:553-561.
-
(2007)
Stem Cells
, vol.25
, pp. 553-561
-
-
Chen, S.S.1
Fitzgerald, W.2
Zimmerberg, J.3
-
5
-
-
0030953763
-
Geometric control of cell life and death
-
Chen CS, Mrksich M, Huang S, et al. Geometric control of cell life and death. Science 1997; 276:1425-1428.
-
(1997)
Science
, vol.276
, pp. 1425-1428
-
-
Chen, C.S.1
Mrksich, M.2
Huang, S.3
-
6
-
-
0032881990
-
Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates
-
Dike LE, Chen CS, Mrksich M, et al. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev Biol Anim 1999; 35:441-448.
-
(1999)
In Vitro Cell Dev Biol Anim
, vol.35
, pp. 441-448
-
-
Dike, L.E.1
Chen, C.S.2
Mrksich, M.3
-
7
-
-
0036325856
-
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces
-
Parker KK, Brock AL, Brangwynne C, et al. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J 2002; 16:1195-1204.
-
(2002)
FASEB J
, vol.16
, pp. 1195-1204
-
-
Parker, K.K.1
Brock, A.L.2
Brangwynne, C.3
-
8
-
-
0033917881
-
Cell movement is guided by the rigidity of the substrate
-
Lo CM, Wang HB, Dembo M, Wang YL. Cell movement is guided by the rigidity of the substrate. Biophys J 2000; 79:144-152.
-
(2000)
Biophys J
, vol.79
, pp. 144-152
-
-
Lo, C.M.1
Wang, H.B.2
Dembo, M.3
Wang, Y.L.4
-
9
-
-
33846610947
-
Mechanical strain regulates endothelial cell patterning in vitro
-
Applied mechanical forces are shown to regulate the direction of endothelial cell migration, as well as proliferation and tubular differentiation in 3D cultures
-
Matsumoto T, Yung YC, Fischbach C, et al. Mechanical strain regulates endothelial cell patterning in vitro. Tissue Eng 2007; 13:207-217. Applied mechanical forces are shown to regulate the direction of endothelial cell migration, as well as proliferation and tubular differentiation in 3D cultures.
-
(2007)
Tissue Eng
, vol.13
, pp. 207-217
-
-
Matsumoto, T.1
Yung, Y.C.2
Fischbach, C.3
-
10
-
-
35649026279
-
Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin
-
Static and cyclic tension are shown to stimulate cell proliferation and vascular remodeling in living skin
-
Pietramaggiori G, Liu P, Scherer SS, et al. Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Ann Surg 2007; 246:896-902. Static and cyclic tension are shown to stimulate cell proliferation and vascular remodeling in living skin.
-
(2007)
Ann Surg
, vol.246
, pp. 896-902
-
-
Pietramaggiori, G.1
Liu, P.2
Scherer, S.S.3
-
11
-
-
33644866797
-
Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response
-
Tzima E. Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response. Circ Res 2006; 98:176-185.
-
(2006)
Circ Res
, vol.98
, pp. 176-185
-
-
Tzima, E.1
-
12
-
-
1842426730
-
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
-
McBeath R, Pirone DM, Nelson CM, et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 2004; 6:483-495.
-
(2004)
Dev Cell
, vol.6
, pp. 483-495
-
-
McBeath, R.1
Pirone, D.M.2
Nelson, C.M.3
-
13
-
-
33747152561
-
Matrix elasticity directs stem cell lineage specification
-
Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006; 126:677-689.
-
(2006)
Cell
, vol.126
, pp. 677-689
-
-
Engler, A.J.1
Sen, S.2
Sweeney, H.L.3
Discher, D.E.4
-
14
-
-
2942707853
-
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition
-
Mammoto A, Huang S, Moore K, et al. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem 2004; 279:26323-26330.
-
(2004)
J Biol Chem
, vol.279
, pp. 26323-26330
-
-
Mammoto, A.1
Huang, S.2
Moore, K.3
-
15
-
-
0037453716
-
Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis
-
Sordella R, Jiang W, Chen GC, et al. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 2003; 113:147-158.
-
(2003)
Cell
, vol.113
, pp. 147-158
-
-
Sordella, R.1
Jiang, W.2
Chen, G.C.3
-
16
-
-
34548621771
-
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension
-
Cell adhesion and associated changes in cell shape and cytoskeletal tension are shown to modulate the Rho signaling pathway via a complex feedback system
-
Bhadriraju K, Yang M, Alom Ruiz S, et al. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res 2007; 313:3616-3623. Cell adhesion and associated changes in cell shape and cytoskeletal tension are shown to modulate the Rho signaling pathway via a complex feedback system.
-
(2007)
Exp Cell Res
, vol.313
, pp. 3616-3623
-
-
Bhadriraju, K.1
Yang, M.2
Alom Ruiz, S.3
-
17
-
-
33746031475
-
An inhibitory role for FAK in regulating proliferation: A link between limited adhesion and RhoA-ROCK signaling
-
Pirone DM, Liu WF, Ruiz SA, et al. An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol 2006; 174:277-288.
-
(2006)
J Cell Biol
, vol.174
, pp. 277-288
-
-
Pirone, D.M.1
Liu, W.F.2
Ruiz, S.A.3
-
18
-
-
9644254216
-
Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: Role of RhoA
-
Seibold S, Schurle D, Heinloth A, et al. Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA. J Am Soc Nephrol 2004; 15:3026-3034.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 3026-3034
-
-
Seibold, S.1
Schurle, D.2
Heinloth, A.3
-
19
-
-
0347986550
-
Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8
-
Fujiwara H, Gu J, Sekiguchi K. Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8. Exp Cell Res 2004; 292:67-77.
-
(2004)
Exp Cell Res
, vol.292
, pp. 67-77
-
-
Fujiwara, H.1
Gu, J.2
Sekiguchi, K.3
-
20
-
-
0034791297
-
NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis
-
Dormond O, Foletti A, Paroz C, Ruegg C. NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat Med 2001; 7:1041-1047.
-
(2001)
Nat Med
, vol.7
, pp. 1041-1047
-
-
Dormond, O.1
Foletti, A.2
Paroz, C.3
Ruegg, C.4
-
21
-
-
33744477889
-
Control of the direction of lamellipodia extension through changes in the balance between Rac and Rho activities
-
Brock AL, Ingber DE. Control of the direction of lamellipodia extension through changes in the balance between Rac and Rho activities. Mol Cell Biomech 2005; 2:135-143.
-
(2005)
Mol Cell Biomech
, vol.2
, pp. 135-143
-
-
Brock, A.L.1
Ingber, D.E.2
-
22
-
-
0035844869
-
Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
-
Riveline D, Zamir E, Balaban NQ, et al. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 2001; 153:1175-1186.
-
(2001)
J Cell Biol
, vol.153
, pp. 1175-1186
-
-
Riveline, D.1
Zamir, E.2
Balaban, N.Q.3
-
23
-
-
33644901594
-
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells
-
Lele TP, Pendse J, Kumar S, et al. Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol 2006; 207:187-194.
-
(2006)
J Cell Physiol
, vol.207
, pp. 187-194
-
-
Lele, T.P.1
Pendse, J.2
Kumar, S.3
-
24
-
-
33751335857
-
Force sensing by mechanical extension of the Src family kinase substrate p130Cas
-
Sawada Y, Tamada M, Dubin-Thaler BJ, et al. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 2006; 127:1015-1026.
-
(2006)
Cell
, vol.127
, pp. 1015-1026
-
-
Sawada, Y.1
Tamada, M.2
Dubin-Thaler, B.J.3
-
25
-
-
0036293439
-
Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation
-
Goldmann WH, Ingber DE. Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Biochem Biophys Res Commun 2002; 290:749-755.
-
(2002)
Biochem Biophys Res Commun
, vol.290
, pp. 749-755
-
-
Goldmann, W.H.1
Ingber, D.E.2
-
26
-
-
44949185543
-
-
Xia N, Thodeti CK, Hunt TP, et al. Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J 2008; 7 Jan [Epub ahead of print]. This paper demonstrates that physical properties of the ECM influence directional cell movement by dictating where cells will form new focal adhesions and activate Rac and, hence, govern where new membrane protrusions will form.
-
Xia N, Thodeti CK, Hunt TP, et al. Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J 2008; 7 Jan [Epub ahead of print]. This paper demonstrates that physical properties of the ECM influence directional cell movement by dictating where cells will form new focal adhesions and activate Rac and, hence, govern where new membrane protrusions will form.
-
-
-
-
27
-
-
9444243244
-
Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis
-
Chai J, Jones MK, Tarnawski AS. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis. FASEB J 2004; 18:1264-1266.
-
(2004)
FASEB J
, vol.18
, pp. 1264-1266
-
-
Chai, J.1
Jones, M.K.2
Tarnawski, A.S.3
-
29
-
-
22144443812
-
The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A
-
Kishore R, Qin G, Luedemann C, et al. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest 2005; 115:1785-1796.
-
(2005)
J Clin Invest
, vol.115
, pp. 1785-1796
-
-
Kishore, R.1
Qin, G.2
Luedemann, C.3
-
30
-
-
12344296398
-
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension
-
Moore KA, Polte T, Huang S, et al. Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn 2005; 232:268-281.
-
(2005)
Dev Dyn
, vol.232
, pp. 268-281
-
-
Moore, K.A.1
Polte, T.2
Huang, S.3
-
31
-
-
33745467623
-
Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis
-
Hunter SG, Zhuang G, Brantley-Sieders D, et al. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol Cell Biol 2006; 26:4830-4842.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4830-4842
-
-
Hunter, S.G.1
Zhuang, G.2
Brantley-Sieders, D.3
-
32
-
-
13544264582
-
Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells
-
Shikata Y, Rios A, Kawkitinarong K, et al. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp Cell Res 2005; 304:40-49.
-
(2005)
Exp Cell Res
, vol.304
, pp. 40-49
-
-
Shikata, Y.1
Rios, A.2
Kawkitinarong, K.3
-
33
-
-
0141816964
-
VEGF-C mediates cyclic pressure-induced endothelial cell proliferation
-
Shin HY, Smith ML, Toy KJ, et al. VEGF-C mediates cyclic pressure-induced endothelial cell proliferation. Physiol Genomics 2002; 11:245-251.
-
(2002)
Physiol Genomics
, vol.11
, pp. 245-251
-
-
Shin, H.Y.1
Smith, M.L.2
Toy, K.J.3
-
34
-
-
0037418727
-
Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner
-
Shiu YT, Li S, Yuan S, et al. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun 2003; 303:548-555.
-
(2003)
Biochem Biophys Res Commun
, vol.303
, pp. 548-555
-
-
Shiu, Y.T.1
Li, S.2
Yuan, S.3
-
35
-
-
0037786965
-
Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins
-
Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res 2003; 92:1296-1304.
-
(2003)
Circ Res
, vol.92
, pp. 1296-1304
-
-
Lin, T.1
Zeng, L.2
Liu, Y.3
-
36
-
-
0037731922
-
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
-
Wojciak-Stothard B, Ridley AJ. Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol 2003; 161:429-439.
-
(2003)
J Cell Biol
, vol.161
, pp. 429-439
-
-
Wojciak-Stothard, B.1
Ridley, A.J.2
-
37
-
-
1942519286
-
Rho mediates the shear enhancement of endothelial cell migration and traction force generation
-
Shiu YT, Li S, Marganski WA, et al. Rho mediates the shear enhancement of endothelial cell migration and traction force generation. Biophys J 2004; 86:2558-2565.
-
(2004)
Biophys J
, vol.86
, pp. 2558-2565
-
-
Shiu, Y.T.1
Li, S.2
Marganski, W.A.3
-
38
-
-
30344460532
-
ERK-MAPK signaling opposes Rhokinase to promote endothelial cell survival and sprouting during angiogenesis
-
Mavria G, Vercoulen Y, Yeo M, et al. ERK-MAPK signaling opposes Rhokinase to promote endothelial cell survival and sprouting during angiogenesis. Cancer Cell 2006; 9:33-44.
-
(2006)
Cancer Cell
, vol.9
, pp. 33-44
-
-
Mavria, G.1
Vercoulen, Y.2
Yeo, M.3
-
39
-
-
10844230332
-
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis
-
Croft DR, Sahai E, Mavria G, et al. Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res 2004; 64:8994-9001.
-
(2004)
Cancer Res
, vol.64
, pp. 8994-9001
-
-
Croft, D.R.1
Sahai, E.2
Mavria, G.3
-
40
-
-
35248893422
-
What tangled webs they weave: Rho-GTPase control of angiogenesis
-
A thorough review of Rho proteins as key regulators of angiogenesis and vascular permeability, as well as cell migration, proliferation, survival and ECM remodeling
-
Bryan BA, D'Amore PA. What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell Mol Life Sci 2007; 64:2053-2065. A thorough review of Rho proteins as key regulators of angiogenesis and vascular permeability, as well as cell migration, proliferation, survival and ECM remodeling.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 2053-2065
-
-
Bryan, B.A.1
D'Amore, P.A.2
-
41
-
-
34447627607
-
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo
-
The Rho inhibitor, p190 RhoGAP, is shown to mediate the vessel sealing effects of angiopoietin-1 by balancing Rho and Rac activities in vitro and in vivo
-
Mammoto T, Parikh SM, Mammoto A, et al. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem 2007; 282:23910-23918. The Rho inhibitor, p190 RhoGAP, is shown to mediate the vessel sealing effects of angiopoietin-1 by balancing Rho and Rac activities in vitro and in vivo.
-
(2007)
J Biol Chem
, vol.282
, pp. 23910-23918
-
-
Mammoto, T.1
Parikh, S.M.2
Mammoto, A.3
-
42
-
-
33847339271
-
Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis
-
ECM-specific activation of the Rac effector, PAK, is found to mediate elevated vascular permeability in atherogenesis, an effect that opposes the action of Rac
-
Orr AW, Stockton R, Simmers MB, et al. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J Cell Biol 2007; 176:719-727. ECM-specific activation of the Rac effector, PAK, is found to mediate elevated vascular permeability in atherogenesis, an effect that opposes the action of Rac.
-
(2007)
J Cell Biol
, vol.176
, pp. 719-727
-
-
Orr, A.W.1
Stockton, R.2
Simmers, M.B.3
-
43
-
-
0347989369
-
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction
-
Birukova AA, Smurova K, Birukov KG, et al. Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 2004; 67:64-77.
-
(2004)
Microvasc Res
, vol.67
, pp. 64-77
-
-
Birukova, A.A.1
Smurova, K.2
Birukov, K.G.3
-
45
-
-
33847419281
-
-
Mammoto A, Huang S, Ingber DE. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci 2007; 120:456-467. This study delineates the mechanism by which changes in the structure of the actin cytoskeleton regulates Rho in human capillary endothelial cells. Cytoskeletal distortion induced during initial cell spreading suppresses Rho by increasing calpaindependent cleavage of the cytoskeletal protein filamin, which promotes accumulation of p190RhoGAP in lipid rafts where downstream signaling is activated.
-
Mammoto A, Huang S, Ingber DE. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci 2007; 120:456-467. This study delineates the mechanism by which changes in the structure of the actin cytoskeleton regulates Rho in human capillary endothelial cells. Cytoskeletal distortion induced during initial cell spreading suppresses Rho by increasing calpaindependent cleavage of the cytoskeletal protein filamin, which promotes accumulation of p190RhoGAP in lipid rafts where downstream signaling is activated.
-
-
-
-
46
-
-
34748905448
-
-
van Buul JD, Allingham MJ, Samson T, et al. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte transendothelial migration. J Cell Biol 2007; 178:1279-1293. ICAM1-dependent activation of RhoG is shown to be critical for leukocyte transendothelial migration.
-
van Buul JD, Allingham MJ, Samson T, et al. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte transendothelial migration. J Cell Biol 2007; 178:1279-1293. ICAM1-dependent activation of RhoG is shown to be critical for leukocyte transendothelial migration.
-
-
-
-
47
-
-
35748948971
-
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration
-
Allingham MJ, van Buul JD, Burridge K. ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol 2007; 179:4053-4064.
-
(2007)
J Immunol
, vol.179
, pp. 4053-4064
-
-
Allingham, M.J.1
van Buul, J.D.2
Burridge, K.3
-
48
-
-
33745813930
-
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability
-
Wegmann F, Petri B, Khandoga AG, et al. ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med 2006; 203:1671-1677.
-
(2006)
J Exp Med
, vol.203
, pp. 1671-1677
-
-
Wegmann, F.1
Petri, B.2
Khandoga, A.G.3
-
49
-
-
32644446913
-
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils
-
Francis SA, Shen X, Young JB, et al. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood 2006; 107:1627-1635.
-
(2006)
Blood
, vol.107
, pp. 1627-1635
-
-
Francis, S.A.1
Shen, X.2
Young, J.B.3
-
50
-
-
3342903325
-
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils
-
Gakidis MA, Cullere X, Olson T, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol 2004; 166:273-282.
-
(2004)
J Cell Biol
, vol.166
, pp. 273-282
-
-
Gakidis, M.A.1
Cullere, X.2
Olson, T.3
-
51
-
-
34250353521
-
-
Stockton R, Reutershan J, Scott D, et al. Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK. Mol Biol Cell 2007; 18:2346-2355. The PAK-PIX-GIT1 complex is shown to be critical for ERK-dependent myosin phosphorylation, tension generation and increased vascular permeability in a mouse model of acute lung injury. This may explain in part how Rac regulates vascular permeability through PAK.
-
Stockton R, Reutershan J, Scott D, et al. Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK. Mol Biol Cell 2007; 18:2346-2355. The PAK-PIX-GIT1 complex is shown to be critical for ERK-dependent myosin phosphorylation, tension generation and increased vascular permeability in a mouse model of acute lung injury. This may explain in part how Rac regulates vascular permeability through PAK.
-
-
-
-
52
-
-
1542286233
-
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact
-
Noritake J, Fukata M, Sato K, et al. Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell 2004; 15:1065-1076.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1065-1076
-
-
Noritake, J.1
Fukata, M.2
Sato, K.3
-
53
-
-
33746073002
-
The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization
-
Cancelas JA, Jansen M, Williams DA. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Exp Hematol 2006; 34:976-985.
-
(2006)
Exp Hematol
, vol.34
, pp. 976-985
-
-
Cancelas, J.A.1
Jansen, M.2
Williams, D.A.3
-
54
-
-
33748703837
-
Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment
-
Ghiaur G, Lee A, Bailey J, et al. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood 2006; 108:2087-2094.
-
(2006)
Blood
, vol.108
, pp. 2087-2094
-
-
Ghiaur, G.1
Lee, A.2
Bailey, J.3
-
55
-
-
0142084736
-
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
-
Gu Y, Filippi MD, Cancelas JA, et al. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science 2003; 302:445-449.
-
(2003)
Science
, vol.302
, pp. 445-449
-
-
Gu, Y.1
Filippi, M.D.2
Cancelas, J.A.3
-
56
-
-
0142116231
-
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
-
Walmsley MJ, Ooi SK, Reynolds LF, et al. Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 2003; 302:459-462.
-
(2003)
Science
, vol.302
, pp. 459-462
-
-
Walmsley, M.J.1
Ooi, S.K.2
Reynolds, L.F.3
-
57
-
-
34347390082
-
The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway
-
This paper demonstrates that Rho signaling through ROCK plays an important role in platelet biogenesis by controlling proplatelet formation
-
Chen Z, Naveiras O, Balduini A, et al. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood 2007; 110:171-179. This paper demonstrates that Rho signaling through ROCK plays an important role in platelet biogenesis by controlling proplatelet formation.
-
(2007)
Blood
, vol.110
, pp. 171-179
-
-
Chen, Z.1
Naveiras, O.2
Balduini, A.3
-
58
-
-
34248329215
-
Proplatelet formation is regulated by the Rho/ROCK pathway
-
This paper demonstrates that Rho signaling through ROCK plays an important role in platelet biogenesis by controlling proplatelet formation
-
Chang Y, Aurade F, Larbret F, et al. Proplatelet formation is regulated by the Rho/ROCK pathway. Blood 2007; 109:4229-4236. This paper demonstrates that Rho signaling through ROCK plays an important role in platelet biogenesis by controlling proplatelet formation.
-
(2007)
Blood
, vol.109
, pp. 4229-4236
-
-
Chang, Y.1
Aurade, F.2
Larbret, F.3
-
59
-
-
1642564595
-
Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho
-
Bayless KJ, Davis GE. Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J Biol Chem 2004; 279:11686-11695.
-
(2004)
J Biol Chem
, vol.279
, pp. 11686-11695
-
-
Bayless, K.J.1
Davis, G.E.2
-
60
-
-
33646179573
-
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics
-
Kumar S, Maxwell IZ, Heisterkamp A, et al. Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J 2006; 90:3762-3773.
-
(2006)
Biophys J
, vol.90
, pp. 3762-3773
-
-
Kumar, S.1
Maxwell, I.Z.2
Heisterkamp, A.3
-
61
-
-
33747382078
-
Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement
-
Brangwynne CP, MacKintosh FC, Kumar S, et al. Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol 2006; 173:733-741.
-
(2006)
J Cell Biol
, vol.173
, pp. 733-741
-
-
Brangwynne, C.P.1
MacKintosh, F.C.2
Kumar, S.3
-
62
-
-
33646340966
-
Mechanical control of tissue morphogenesis during embryological development
-
Ingber DE. Mechanical control of tissue morphogenesis during embryological development. Int J Dev Biol 2006; 50:255-266.
-
(2006)
Int J Dev Biol
, vol.50
, pp. 255-266
-
-
Ingber, D.E.1
-
63
-
-
33644967727
-
Cellular adaptation to mechanical stress: Role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels
-
Matthews BD, Overby DR, Mannix R, Ingber DE. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci 2006; 119:508-518.
-
(2006)
J Cell Sci
, vol.119
, pp. 508-518
-
-
Matthews, B.D.1
Overby, D.R.2
Mannix, R.3
Ingber, D.E.4
-
64
-
-
34548321321
-
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells
-
The response to mechanical strain and the relative contributions of Rho and Rac signaling are shown to be different in endothelial cells in comparison with smooth muscle cells from pulmonary artery
-
Liu WF, Nelson CM, Tan JL, Chen CS. Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res 2007; 101:e44-e52. The response to mechanical strain and the relative contributions of Rho and Rac signaling are shown to be different in endothelial cells in comparison with smooth muscle cells from pulmonary artery.
-
(2007)
Circ Res
, vol.101
-
-
Liu, W.F.1
Nelson, C.M.2
Tan, J.L.3
Chen, C.S.4
-
65
-
-
1442276317
-
Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress
-
Polte TR, Eichler GS, Wang N, Ingber DE. Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. Am J Physiol Cell Physiol 2004; 286:C518-528.
-
(2004)
Am J Physiol Cell Physiol
, vol.286
-
-
Polte, T.R.1
Eichler, G.S.2
Wang, N.3
Ingber, D.E.4
-
66
-
-
33746658154
-
-
Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac bindsfilamin A to control actin remodelling. Nat Cell Biol 2006; 8:803-814.
-
Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac bindsfilamin A to control actin remodelling. Nat Cell Biol 2006; 8:803-814.
-
-
-
-
67
-
-
1942466518
-
p27Kip1 modulates cell migration through the regulation of RhoA activation
-
Besson A, Gurian-West M, Schmidt A, et al. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004; 18:862-876.
-
(2004)
Genes Dev
, vol.18
, pp. 862-876
-
-
Besson, A.1
Gurian-West, M.2
Schmidt, A.3
|