L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner

Neuroscience Research

Volumn 61, Issue 1, 2008, Pages 43-48

  Moriwaki, Yasuhiro ^a,b   Kim, Yeon Jeong ^b   Ido, Yukari ^a   Misawa, Hidemi ^a   Kawashima, Koichiro ^a   Endo, Shogo ^c   Takahashi, Ryosuke ^b,d  

^a KEIO UNIVERSITY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cdc37; Hsp90; Parkinson's disease; PINK1; Proteasome; Stability

Indexed keywords

CELL CYCLE PROTEIN 37; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; NOVOBIOCIN; PHOSPHOTRANSFERASE; PTEN INDUCED KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION;

ANIMALS; BENZOQUINONES; CELL CYCLE PROTEINS; CERCOPITHECUS AETHIOPS; CHAPERONINS; COS CELLS; CYSTEINE PROTEINASE INHIBITORS; HALF-LIFE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MASS SPECTROMETRY; MUTATION; NOVOBIOCIN; PARKINSON DISEASE; PLASMIDS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 41949098617     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2008.01.006     Document Type: Article

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