Fbx8 makes Arf6 refractory to function via ubiquitination

Molecular Biology of the Cell

Volumn 19, Issue 3, 2008, Pages 822-832

  Yano, Hajime ^a   Kobayashi, Itaru ^a,b   Onodera, Yasuhito ^a   Luton, Frédéric ^c   Franco, Michel ^c   Mazaki, Yuichi ^a   Hashimoto, Shigeru ^a   Iwai, Kazuhiro ^d   Ronai, Ze'ev ^e   Sabe, Hisataka ^a,b  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c CNRS   (France)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; F BOX PROTEIN; PROTEIN FBX8; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; UBIQUITINATION;

ADP-RIBOSYLATION FACTORS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; F-BOX PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; MICE; NEOPLASM INVASIVENESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITINATION;

EID: 41649103041     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-08-0763     Document Type: Article

References (51)

1. Brown, F. D., Rozelle, A. L., Yin, H. L., Balla, T., and Donaldson, J. G. (2001). Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J. Cell Biol. 154, 1007-1017.
2. Cardazo, T., and Pagano, M. (2004). The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 5, 739-751.
3. Cenciarelli, C., Chiaur, D. S., Guardavaccaro, D., Parks, W., Vidal, M., and Pagano, M. (1999). Identification of a family of human F-box proteins. Curr. Biol. 9, 1177-1179.
4. Chavrier, P., and Franco, M. (2001). Expression, purification, and biochemical properties of EFA6, a Sec7 domain-containing guanine exchange factor for ADP-ribosylation factor6 (Arf6). Methods Enzymol. 329, 272-279.
5. de Melker, A., van der Horst, G., and Borst, J. (2004). Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into Clathrin-coated pits by two distinct modes of Eps15 recruitment. J. Biol. Chem. 279, 55465-55473.
6. Dharmasiri, N., Dharmasiri, S., and Estelle, M. (2005). The F-box protein TIR is an auxin receptor. Nature 435, 441-445.
7. Donaldson, J. G. (2003). Multiple roles for Arf6, Sorting, structuring, and signaling at the plasma membrane. J. Biol. Chem. 278, 41573-41576.
8. D'Souza-Schorey, C., and Stahl, P. D. (1995). Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp. Cell Res. 221, 153-159.
9. D'Souza-Schorey, C., Li, G., Colombo, M. L., and Stahl, P. D. (1995). A regulatory role for ARF6 in receptor-mediated endocytosis. Science 267, 1175-1178.
10. D'Souza-Schorey, C., Boshans, R. L., McDonough, M., Stahl, P. D., and Aelst, L. V. (1997). A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16, 5445-5454.
11. D'Souza-Schorey, C. (2005). Disassembling adherens junctions: breaking up is hard to do. Trends Cell Biol. 15, 19-26.
12. D'Souza-Schorey, C., and Chavrier, P. (2006). ARF proteins: roles in membrane traffic and beyond. Nat. Rev. Mol. Cell Biol. 7, 347-358.
13. Frank, S., Upender, S., Hanse, S. H., and Casanova, J. E. (1998). ARNO is a guanine nucleotide exchange factor for ADP-ribosylation Factor 6. J. Biol. Chem. 273, 23-27.
14. Geetha, T., Jiang, J., and Wooten, M. W. (2005). Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol. Cell 20, 301-312.
15. Glickman, M. H., and Ciechanover, A. (2002). The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82, 373-428.
16. Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Di Fiore, P, P. and Dikic, I. (2003). Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 5, 461-466.
17. Hart, M. J., Eva, A., Zangrilli, D., and Aaronson, S. A., Evans, T., Cerione, R. A., and Zhenf, Y. (1994). Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J. Biol. Chem. 269, 62-65.
18. Hashimoto, S., Onodera, Y., Hashimoto, A., Tanaka, M., Hamaguchi, M., Yamada, A., and Sabe, H. (2004a). Requirement for Arf6 in breast cancer invasive activities. Proc. Natl. Acad. Sci. USA 101, 6647-6652.
19. Hashimoto, S., Hashimoto, A., Yamada, A., Kojima, C., Yamamoto, H., Tsutsumi, T., Higashi, M., Mizoguchi, A., Yagi, R., and Sabe, H. (2004b). A novel mode of action of an ArfGAP, AMAP2/PAG3/Papα, in Arf6 function. J. Biol. Chem. 279, 37677-37684.
20. Hershko, A., and Ciechanover, A. (1992). The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61, 761-807.
21. Hussain, N. K. et al. (2001). Endocytic protein intersectin-1 regulates actin assembly via Cdc42 and N-WASP. Nat. Cell Biol. 3, 927-932.
22. Ilyin, G. P., Rialland, M., Pigeon, C., and Guguen-Guillouzo, C. (2000). cDNA cloning and expression of new members of the mammalian F-box protein family. Genomics 67, 40-47.
23. Jackson, C. L. (2003). The Sec7 family of Arf guanine nucleotide exchange factors. In: Arf family GTPases, ed. R. A. Kahn, Dordrecht, the Netherlands: Kluwer Academic Publications, 71-99.
24. Jin, J., Cardazo, T., Lovering, R. C., Eliedge, S. J., Pagano, M., and Harper, J. W. (2004). Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18, 2573-2580.
25. Jura, N., Scotto-Lavino, E., Sobczyk, A., and Bar-Sagi, D. (2006). Differential modification of Ras proteins by ubiquitination. Mol. Cell 21, 679-687.
26. Kaelin, W. G., Jr. (2005). Proline hydroxylation and gene expression. Annu. Rev. Biochem. 74, 115-128.
27. Lebeda, R. A., Johnson, S. K., Stewart, M. I., and Haun, R. S. (2003). Sequence, genomic organization, and expression of human ADP-ribosylation factor 6 (ARF6): a class III ARF. DNA Cell Biol. 22, 737-741.
28. Logsdon, J. M., and Kahn, R. A. (2003). The Arf family tree. In: Arf family GTPases, ed. R. A. Kahn, Dordrecht, the Netherlands: Kluwer Academic Publications, 1-21.
29. Luton, F., Klein, S., Chauvin, J. P., Le Bivic, A., Bourgoin, S., Franco, M., and Chardin, P. (2004). EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol. Biol. Cell 15, 1134-1145.
30. Lynch, E. A., Stall, J., Schmidt, G., Chavrier, P., and D'Souza-Schorey, C. (2006). Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering. Mol. Biol. Cell 17, 2236-2242.
31. Mazaki, Y. et al. (2001). An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. Mol. Biol. Cell 12, 645-662.
32. Meusser, B., Hirsch, C., Jarosch, E., and Sommer, T. (2005). ERAD: the long road to destruction. Nat. Cell Biol. 7, 766-772.
33. Morgenstern, J. P., and Land, H. (1990). Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18, 3587-3596.
34. Kip1, polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081.
35. Onodera, Y. et al. (2005). Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. EMBO J. 24, 963-973.
36. Palacios, F., Schweitzer, J. K., Boshans, R. L., and D'Souza-Schorey, C. (2002). ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat. Cell Biol. 4, 929-936.
37. Pasqualato, S., Menetrey, J., Franco, M., and Cherfils, J. (2001). The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2, 234-238.
38. Peters, P. J., Hsu, V. W., Ooi, C. E., Finazzi, D., Teal, S. B., Oorschot, V., Donaldson, J. G., and Klausner, R. D. (1995). Overexpression of wild-type and mutant ARF1 and ARF 6, distinct perturbations of nonoverlapping membrane compartments. J. Cell Biol. 128, 1003-1017.
39. Radhakrishna, H., Klausner, R. D., and Donaldson, J. G. (1996). Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J. Cell Biol. 134, 935-947.
40. Radhakrishna , H., and Donaldson, J. G. (1997). ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J. Cell Biol. 139, 49-61.
41. Radhakrishna, H., Al-Awar, O., Khachikian, Z., and Donaldson, J. G. (1999). ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J. Cell Sci. 112, 855-866.
42. Sabe, H. (2003). Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion. J. Biochem. 134, 485-489.
43. Sahai, E., Garcia-Medina, R., Pouyssegur, J., and Vial, E. (2007). Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J. Cell Biol. 176, 35-42.
44. Sun, L., and Chen, Z. L. (2004). The novel functions of ubiquitination in signaling. Curr. Opin. Cell Biol. 16, 119-126.
45. Tague, S. E., Muralidharan, V., and D'Souza-Schorey, C. (2004). ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway. Proc. Natl. Acad. Sci. USA 101, 9671-9676.
46. van Drogon, F., Sangfelt, O., Malyukova, A., Matskova, L., Yeh, E., Means, A. R., and Reed, S. I. (2006). Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol. Cell 23, 37-48.
47. Volpicelli-Daley, L. A., Li, Y., Zhang, C. J., and Kahn, R. A. (2005). Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic. Mol. Biol. Cell 16, 4495-4508.
48. Wang, H., Zhang, Y., Ozdamar, B., Ogunjimi, A. A., Alexandrova, E., Thomsen, G. H., and Wrana, J. L. (2003). Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 302, 1775-1779.
49. Winston, J. T., Koepp, D. M., Zhu, C., Elledge, S. J., and Harper, J. W. (1999). A family of mammalian F-box proteins. Curr. Biol. 9, 1180-1182.
50. Zhang, Q., Cox, D., Tseng, C. C., Donaldson, J. G., and Greenberg, S. (1998). A requirement for Arf6 in Fcγ receptor-mediated phagocytosis in macrophages. J. Biol. Chem. 273, 19977-19981.
51. Zhu, H., Kavsak, Abdollah, P., S., Wrana, J. L., and Thomsen, G. H. (1999). A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693.