Synergy between broccoli sprout extract and selenium in the upregulation of thioredoxin reductase in human hepatocytes

Food Chemistry

Volumn 110, Issue 1, 2008, Pages 193-198

  Li, Dan ^a,b   Wu, Kun ^b   Howie, A Forbes ^c   Beckett, Geoffrey J ^c   Wang, Wei ^a   Bao, Yongping ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cruciferous vegetables; Hepatocyte; Isothiocyanates; Selenium; Sulforaphane; Thioredoxin reductase

Indexed keywords

BROCCOLI SPROUT EXTRACT; ERUCIN; IBERIN; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; PLANT EXTRACT; SELENIUM; SULFORAPHANE; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG;

ARTICLE; BROCCOLI; CELL IMMORTALIZATION; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; REGULATORY MECHANISM; SPROUT; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; UPREGULATION;

BRASSICA OLERACEA VAR. ITALICA;

EID: 41549166452     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2008.01.032     Document Type: Article

References (39)

1. Ambrosone C.B., McCann S.E., Freudenheim J.L., Marshall J.R., Zhang Y., and Shields P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. Journal of Nutrition 134 (2004) 1134-1138
2. Bacon J., Plumb G., Howie A.F., Beckett G.J., Wang W., and Bao Y.P. The dual-action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells. Journal of Agricultural and Food Chemistry 55 (2007) 1170-1176
3. Bacon J., Williamson G., Garner C., Lappin G., Langouet S., and Bao Y.P. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human Hep G2 and hepatocytes. Carcinogenesis 24 (2003) 1903-1911
4. Bao Y.P., and Fenwick R. Future perspectives in phytochemicals and health research. In: Bao Y.P., and Fenwick R. (Eds). Phytochemicals in health and disease (2004), Marcel Dekker Inc., New York 331-342
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein, utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1976) 248-254
6. Campbell L., Howie F., Arthur J., Nicol G., and Beckett G. Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage. Nutrition 23 (2007) 138-144
7. Clayton R.F., Rinaldi A., Kandyba E.E., Edward M., Willberg C., Klenerman P., et al. Liver cell lines for the study of hepatocyte functions and immunological response. Liver International 25 2 (2005) 389-402
8. Conaway C.C., Yang Y.M., and Chung F.L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Current Drug Metabolism 3 (2002) 233-255
9. Davis C.D., Zeng H., and Finley J.W. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice. Journal of Nutrition 132 (2002) 307-309
10. Elliot R., Bacon J., and Bao Y.P. Nutritional genomics. In: Bao Y.P., and Fenwick R. (Eds). Phytochemicals in health and disease (2004), Marcel Dekker Inc., New York 1-25
11. Fahey J.W., Zhang Y., and Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 10367-10372
12. Faulkner K., Mithen R., and Williamson G. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli. Carcinogenesis 19 (1998) 605-609
13. Fenwick G.R., Heaney R.K., and Mullin W.J. Glucosinolates and their breakdown products in food and food plants. Critical Reviews in Food Science and Nutrition 18 2 (1983) 123-201
14. Gasper A.V., Al-Janobi A., Smith J.A., Bacon J.R., Fortun P., Atherton C., et al. Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. The American Journal of Clinical Nutrition 82 6 (2005) 1283-1291
15. Holmgren A., and Bjornstedt M. Thioredoxin and thioredoxin reductase. Methods in Enzymology 252 (1995) 199-208
16. Keck A.S., and Finley J.W. Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integrative Cancer Therapies 3 (2004) 5-12
17. Kensler T.W., Chen J.G., Egner P.A., Fahey J.W., Jacobson L.P., Stephenson K.K., et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiology, Biomarkers & Prevention 14 (2005) 2605-2613
18. Lincoln D.T., Ali Emadi E.M., Tonissen K.F., and Clarke F.M. The thioredoxin-thioredoxin reductase system: over-expression in human cancer. Anticancer Research 23 (2003) 2425-2433
19. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 4 (2001) 402-408
20. Miller S., Walker S.W., Arthur J.R., Nicol F., Pickard K., Lewin M.H., et al. Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clinical Science 100 (2001) 543-550
21. Rask L., Andreasson E., Ekbom B., Eriksson S., Pontoppidan B., and Meijer J. Myrosinase: gene family evolution and herbivore defence in Brassicaceae. Plant Molecular Biology 42 (2000) 93-113
22. Sandalova T., Zhong L., Lindqvist Y., Holmgren A., and Schneider G. Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 9533-9538
23. Shan Y., Sun C., Zhao X., Wu K., Cassidy A., and Bao Y.P. Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells. International Journal of Oncology 29 (2006) 883-888
24. Sivakumar G., Aliboni A., and Bacchetta L. HPLC screening of anti-cancer sulforaphane from important European Brassica Species. Food Chemistry 104 (2007) 1761-1764
25. Soderberg A., Sahaf B., and Rosen A. Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma. Cancer Research 60 (2000) 2281-2289
26. Tanaka T., Nakamura H., Nishiyama A., Hosoi F., Masutani H., Wada H., et al. Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging. Free Radical Research 33 (2001) 851-855
27. Talalay P., and Fahey J.W. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. Journal of Nutrition 131 Suppl. (2001) 3027S-3033S
28. Tang L., Zhang Y., Jobson H.E., Li J., Stephenson K.K., Wade K.L., et al. Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. Molecular Cancer Therapeutics 5 4 (2006) 935-944
29. Verhoeven D.T., Goldbohm R.A., van Poppel G., Verhagen H., and van den Brandt P.A. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiology, Biomarkers & Prevention 5 (1996) 733-748
30. Wang W., Wang S.A., Howie F., Beckett G., Mithen R., and Bao Y.P. Sulforaphane, erucin and iberin up-regulate thioredoxin reductase expression in human MCF-7 cells. Journal of Agricultural and Food Chemistry 53 (2005) 1417-1421
31. Whanger P.D. Selenium and its relationship to cancer: an update dagger. The British Journal of Nutrition 91 (2004) 11-28
32. Xia L., Nordman T., Olsson M., Damdimopoulos A., Bjorkhem-Bergman L., Nalvarte I., et al. The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. The Journal of Biological Chemistry 278 (2003) 2141-2146
33. Ye L., Dinkova-Kostova A.T., Wade K.L., Zhang Y., Shapiro T.A., and Talalay P. Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clinica Chimica Acta 316 (2002) 43-53
34. Yeh J.Y., Ou B.R., Liang Y.C., Burchfiel J., Butler J.A., Forsberg N.E., et al. Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells. Biometals 19 (2006) 611-621
35. Zeng H., Davis C.D., and Finley J.W. Effect of selenium-enriched broccoli diet on differential gene expression in min mouse liver. The Journal of Nutritional Biochemistry 14 (2003) 227-231
36. Zhang J.S., Svehlikova V., Bao Y.P., Howie A.F., Beckett G.J., and Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24 (2003) 497-503
37. Zhang Y., Munday R., Jobson H.E., Munday C.M., Lister C., Wilson P., et al. Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea L. var. italica) sprouts. Journal of Agricultural and Food Chemistry 54 25 (2006) 9370-9376
38. Zhao H., Lin J., Grossman H.B., Hernandez L.M., Dinney C.P., and Wu X. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. International Journal of Cancer 120 10 (2007) 2208-2213
39. Zhong L., and Holmgren A. Mammalian thioredoxin reductases as hydroperoxide reductases. Methods Enzymology 347 (2002) 236-243