An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3

Endocrinology

Volumn 149, Issue 4, 2008, Pages 1705-1717

  Feng, Xiuyan ^a   Müller, Thomas ^a,c   Mizrachi, Dario ^a,d   Fanelli, Francesca ^b   Segaloff, Deborah L ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c GERMAN PRIMATE CENTER   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; HELIX 3 PROTEIN; HELIX 6 PROTEIN; HELIX LOOP HELIX PROTEIN; LUTEINIZING HORMONE RECEPTOR; SOLVENT; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSOL; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; INTRACELLULAR LOOP; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELLS, CULTURED; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECEPTORS, LH; RECEPTORS, THYROTROPIN;

EID: 41549162492     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1341     Document Type: Article

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