Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants

Drug Metabolism and Disposition

Volumn 36, Issue 4, 2008, Pages 745-752

  Han, Jing Fen ^a   He, Xiao Yang ^a   Herrington, Jason S ^a   White, Lori A ^b   Zhang, Jun Feng ^a   Hong, Jun Yan ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ALANINE; ASPARAGINE; BIOLOGICAL MARKER; CARCINOGEN; CYSTEINE; CYTOCHROME P450 1B1; GLUTAMIC ACID; GLYCINE; LEUCINE; PROLINE; SERINE; TRYPTOPHAN; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; EXPOSURE; GENETIC VARIABILITY; HUMAN; HYDROXYLATION; METABOLIC ACTIVATION; METABOLITE; MICROSOME; MISSENSE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; IMIDAZOLES; INSECTS; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES; RATS; SPECIES SPECIFICITY; VARIATION (GENETICS);

EID: 41549157333     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016824     Document Type: Article

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