Effect of genetic variation on human cytochrome P450 reductase-mediated paraquat cytotoxicity

Toxicological Sciences

Volumn 91, Issue 1, 2006, Pages 42-48

  Han, Jing Fen ^a   Wang, Shou Lin ^a   He, Xiao Yang ^a   Liu, Chun Yung ^a   Hong, Jun Yan ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Flp In CHO cells; Genetic variants; NADPH cytochrome POR; Paraquat; siRNA knockdown

Indexed keywords

ALANINE; ARGININE; ASPARTIC ACID; CYSTEINE; CYTOCHROME P450 REDUCTASE; GLUTAMINE; HERBICIDE; HISTIDINE; PARAQUAT; PHENYLALANINE; PROLINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; SUPEROXIDE; TYROSINE; VALINE;

ALLELE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE PREDISPOSITION; ENVIRONMENTAL EXPOSURE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MISSENSE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PARAQUAT POISONING; PROTEIN EXPRESSION; STEROIDOGENESIS; WILD TYPE;

ALLELES; ANIMALS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; HERBICIDES; HUMANS; MICE; NADPH-FERRIHEMOPROTEIN REDUCTASE; PARAQUAT; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; VARIATION (GENETICS);

ANIMALIA; CRICETULUS GRISEUS;

EID: 33645818541     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj139     Document Type: Article

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