Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol

Pharmacogenetics

Volumn 10, Issue 4, 2000, Pages 343-353

  Li, Dongtao N ^a   Seidel, Albrecht ^b   Pritchard, Michael P ^a   Wolf, C Roland ^a   Friedberg, Thomas ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Biochemical Institute for Environmental Carcinogens   (Germany)

Author keywords

Chemical carcinogenesis; Cytochrome P450; Polymorphic drug oxidations; Steroid metabolism

Indexed keywords

4 HYDROXYESTRADIOL; BENZO[A]PYRENE DERIVATIVE; BUFURALOL; CARCINOGEN; COMPLEMENTARY DNA; CYTOCHROME P450; ESTRADIOL; ETHOXYRESORUFIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DNA POLYMORPHISM; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME POLYMORPHISM; EPOXIDATION; ESCHERICHIA COLI; ESTROGEN METABOLISM; HYDROXYLATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI;

EID: 0034039377     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200006000-00008     Document Type: Article

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