메뉴 건너뛰기




Volumn 11, Issue 23, 1997, Pages 3206-3217

Cryptococcus neoformans mating and virulence are regulated by the G- protein α subunit GPA1 and cAMP

Author keywords

Capsule; Cryptococcus; G protein; Melanin; Pathogenesis; Signal transduction

Indexed keywords

CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

EID: 0030668723     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.23.3206     Document Type: Article
Times cited : (343)

References (44)
  • 1
    • 0028358806 scopus 로고
    • Diversity in function and regulation of MAP kinase pathways
    • Blumer, K.J. and G.L. Johnson. 1994. Diversity in function and regulation of MAP kinase pathways. Trends Biosci. 19: 236-240.
    • (1994) Trends Biosci. , vol.19 , pp. 236-240
    • Blumer, K.J.1    Johnson, G.L.2
  • 2
    • 0028321560 scopus 로고
    • Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence
    • Chang, Y.C. and K.J. Kwon-Chung. 1994. Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol. Cell. Biol. 14:4912-4919.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4912-4919
    • Chang, Y.C.1    Kwon-Chung, K.J.2
  • 3
    • 0029886340 scopus 로고    scopus 로고
    • The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence
    • Chang, Y.C., L.A. Penoyer, and K.J. Kwon-Chung. 1996. The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence. Infect. Immun. 64: 1977-1983.
    • (1996) Infect. Immun. , vol.64 , pp. 1977-1983
    • Chang, Y.C.1    Penoyer, L.A.2    Kwon-Chung, K.J.3
  • 4
    • 0029798362 scopus 로고    scopus 로고
    • Extensive alteration of fungal gene transcript accumulation and elevation of G-protein-regulated cAMP levels by a virulence-attenuating hypovirus
    • Chen, B., S. Gao, G.H. Choi, and D.L. Nuss. 1996. Extensive alteration of fungal gene transcript accumulation and elevation of G-protein-regulated cAMP levels by a virulence-attenuating hypovirus. Proc. Natl. Acad. Sci. 93: 7996-8000.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 7996-8000
    • Chen, B.1    Gao, S.2    Choi, G.H.3    Nuss, D.L.4
  • 5
    • 0028909157 scopus 로고
    • Virus-mediated or transgenic suppression of a G-protein α subunit and attenuation of fungal virulence
    • Choi, G.H., B. Chen, and D.L. Nuss. 1995. Virus-mediated or transgenic suppression of a G-protein α subunit and attenuation of fungal virulence. Proc. Natl. Acad. Sci. 92: 305-309.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 305-309
    • Choi, G.H.1    Chen, B.2    Nuss, D.L.3
  • 6
    • 79961163503 scopus 로고    scopus 로고
    • Dominant selection system for use in Cryptococcus neoformans
    • Cox, G.M., D.L. Toffaletti, and J.R. Perfect. 1996. Dominant selection system for use in Cryptococcus neoformans. J. Med. Vet. Mycol. 34: 385-391.
    • (1996) J. Med. Vet. Mycol. , vol.34 , pp. 385-391
    • Cox, G.M.1    Toffaletti, D.L.2    Perfect, J.R.3
  • 7
    • 0020452610 scopus 로고
    • Decreased virulence in stable acapsular mutants of Cryptococcus neoformans
    • Fromtling, R.A., H.K. Shadomy, and E.S. Jacobson. 1982. Decreased virulence in stable acapsular mutants of Cryptococcus neoformans. Mycopathologia 79: 23-29.
    • (1982) Mycopathologia , vol.79 , pp. 23-29
    • Fromtling, R.A.1    Shadomy, H.K.2    Jacobson, E.S.3
  • 8
    • 0030462464 scopus 로고    scopus 로고
    • Distinct roles for two G protein α subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption
    • Gao, S. and D.L. Nuss. 1996. Distinct roles for two G protein α subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption. Proc. Natl. Acad. Sci. 93: 14122-14127.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 14122-14127
    • Gao, S.1    Nuss, D.L.2
  • 9
    • 0029282131 scopus 로고
    • G proteins and regulation of adenylyl cyclase
    • Gilman, A.G. 1995. G proteins and regulation of adenylyl cyclase. Biosci. Rep. 15: 65-97.
    • (1995) Biosci. Rep. , vol.15 , pp. 65-97
    • Gilman, A.G.1
  • 10
    • 0028171311 scopus 로고
    • cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis
    • Gold, S., G. Duncan, K. Barrett, and J. Kronstad. 1994. cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis. Genes & Dev. 8: 2805-2816.
    • (1994) Genes & Dev. , vol.8 , pp. 2805-2816
    • Gold, S.1    Duncan, G.2    Barrett, K.3    Kronstad, J.4
  • 11
    • 0021997066 scopus 로고
    • Virulence at Cryptococcus neoformans: Regulation of capsule synthesis by carbon dioxide
    • Granger, D.L., J.R. Perfect, and D.T. Durack. 1985. Virulence at Cryptococcus neoformans: Regulation of capsule synthesis by carbon dioxide. J. Clin. Invest. 76: 508-516.
    • (1985) J. Clin. Invest. , vol.76 , pp. 508-516
    • Granger, D.L.1    Perfect, J.R.2    Durack, D.T.3
  • 12
    • 0027078059 scopus 로고
    • Characterization of a fission yeast gene, gpa2, that encodes a Ga subunit involved in the monitoring of nutrition
    • Isshiki, T., N. Mochizuki, T. Maeda, and M. Yamamoto. 1992. Characterization of a fission yeast gene, gpa2, that encodes a Ga subunit involved in the monitoring of nutrition. Genes & Dev. 6: 2455-2462.
    • (1992) Genes & Dev. , vol.6 , pp. 2455-2462
    • Isshiki, T.1    Mochizuki, N.2    Maeda, T.3    Yamamoto, M.4
  • 13
    • 84907128142 scopus 로고
    • Temperature regulation of the cryptococcal phenoloxidase
    • Jacobson, E.S. and H.S. Emery. 1991. Temperature regulation of the cryptococcal phenoloxidase. J. Med. Vet. Mycol. 29: 121-124.
    • (1991) J. Med. Vet. Mycol. , vol.29 , pp. 121-124
    • Jacobson, E.S.1    Emery, H.S.2
  • 14
    • 0018196299 scopus 로고
    • Distribution of a and α mating types of Cryptococcus neoformans among natural and clinical isolates
    • Kwon-Chung, J.J. and J.E. Bennett. 1978. Distribution of a and α mating types of Cryptococcus neoformans among natural and clinical isolates. Am. J. Epidemiol. 108: 337-340.
    • (1978) Am. J. Epidemiol. , vol.108 , pp. 337-340
    • Kwon-Chung, J.J.1    Bennett, J.E.2
  • 15
    • 0016975715 scopus 로고
    • Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans
    • Kwon-Chung, K.J. 1976. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68: 942-946.
    • (1976) Mycologia , vol.68 , pp. 942-946
    • Kwon-Chung, K.J.1
  • 16
    • 0022635758 scopus 로고
    • Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans
    • Kwon-Chung, K.J. and J.C. Rhodes. 1986. Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect. Immun. 51: 218-223.
    • (1986) Infect. Immun. , vol.51 , pp. 218-223
    • Kwon-Chung, K.J.1    Rhodes, J.C.2
  • 17
    • 0026334016 scopus 로고
    • Genetic association of mating types and virulence in Cryptococcus neoformans
    • Kwon-Chung, K.J., J.C. Edman, and B.L. Wickes. 1992. Genetic association of mating types and virulence in Cryptococcus neoformans. Infect. Immun. 60: 602-605.
    • (1992) Infect. Immun. , vol.60 , pp. 602-605
    • Kwon-Chung, K.J.1    Edman, J.C.2    Wickes, B.L.3
  • 18
    • 0020316973 scopus 로고
    • Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice
    • Kwon-Chung, K.J., I. Polacheck, and T.J. Popkin. 1982. Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J. Bacteriol. 150: 1414-1421.
    • (1982) J. Bacteriol. , vol.150 , pp. 1414-1421
    • Kwon-Chung, K.J.1    Polacheck, I.2    Popkin, T.J.3
  • 19
    • 0028920365 scopus 로고
    • The proliferation of MAP kinase signaling pathways in yeast
    • Levin, D. and B. Errede. 1995. The proliferation of MAP kinase signaling pathways in yeast. Curr. Opin. Cell Biol. 7: 197-202.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 197-202
    • Levin, D.1    Errede, B.2
  • 20
    • 0030703189 scopus 로고    scopus 로고
    • Yeast pseudohyphal growth is regulated by GPA2, a G protein a homolog
    • in press
    • Lorenz, M.C. and J. Heitman. 1997. Yeast pseudohyphal growth is regulated by GPA2, a G protein a homolog. EMBO J. (in press).
    • (1997) EMBO J.
    • Lorenz, M.C.1    Heitman, J.2
  • 21
    • 0026511987 scopus 로고
    • Environmental signals controlling expression of virulence determinants in bacteria
    • Mekalanos, J.J. 1992. Environmental signals controlling expression of virulence determinants in bacteria. J. Bacteriol. 174: 1-6.
    • (1992) J. Bacteriol. , vol.174 , pp. 1-6
    • Mekalanos, J.J.1
  • 22
    • 0028786641 scopus 로고
    • Cryptococcosis in the era of AIDS - 100 years after the discovery of Cryptococcus neoformans
    • Mitchell, T.G. and J.R. Perfect. 1995. Cryptococcosis in the era of AIDS - 100 years after the discovery of Cryptococcus neoformans. Clin. Microbiol. Rev. 8: 515-548.
    • (1995) Clin. Microbiol. Rev. , vol.8 , pp. 515-548
    • Mitchell, T.G.1    Perfect, J.R.2
  • 23
    • 0027479079 scopus 로고
    • The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene
    • Moore, T.D.E. and J.C. Edman. 1993. The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol. Cell. Biol. 13: 1962-1970.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1962-1970
    • Moore, T.D.E.1    Edman, J.C.2
  • 24
    • 0023972484 scopus 로고
    • Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: Studies on its structure and possible functions
    • Nakafuku, M., T. Obara, K. Kaibuchi, I. Miyajima, A. Miyajima, H. Itoh, S. Nakamura, K.-i. Arai, K. Matsumoto, and Y. Kaziro. 1988. Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: Studies on its structure and possible functions. Proc. Natl. Acad. Sci. 85: 1374-1378.
    • (1988) Proc. Natl. Acad. Sci. , vol.85 , pp. 1374-1378
    • Nakafuku, M.1    Obara, T.2    Kaibuchi, K.3    Miyajima, I.4    Miyajima, A.5    Itoh, H.6    Nakamura, S.7    Arai, K.-I.8    Matsumoto, K.9    Kaziro, Y.10
  • 25
    • 0018616480 scopus 로고
    • Regulation of melanin production by Cryptococcus neoformans
    • Nurudeen, T.A. and D.G. Ahearn. 1979. Regulation of melanin production by Cryptococcus neoformans. J. Clin. Microbiol. 10: 724-729.
    • (1979) J. Clin. Microbiol. , vol.10 , pp. 724-729
    • Nurudeen, T.A.1    Ahearn, D.G.2
  • 26
    • 0025999133 scopus 로고
    • Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: Involvement in mating and sporulation pathways
    • Obara, T., M. Nakafuku, M. Yamamoto, and Y. Kaziro. 1991. Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: Involvement in mating and sporulation pathways. Proc. Natl. Acad. Sci. 88: 5877-5881.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 5877-5881
    • Obara, T.1    Nakafuku, M.2    Yamamoto, M.3    Kaziro, Y.4
  • 27
    • 0031008864 scopus 로고    scopus 로고
    • Calcineurin is required for virulence of Cryptococcus neoformans
    • Odom, A., S. Muir, E. Lim, D.L. Toffaletti, J. Perfect, and J. Heitman. 1997. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16: 2576-2589.
    • (1997) EMBO J. , vol.16 , pp. 2576-2589
    • Odom, A.1    Muir, S.2    Lim, E.3    Toffaletti, D.L.4    Perfect, J.5    Heitman, J.6
  • 28
    • 0026685014 scopus 로고
    • Yeast α-mating factor receptor and G-protein-linked adenylyl cyclase inhibition requires RAS2 and GPA2 activities
    • Papasawas, S., S. Arkinstall, J. Reid, and M. Payton. 1992. Yeast α-mating factor receptor and G-protein-linked adenylyl cyclase inhibition requires RAS2 and GPA2 activities. Biochem. Biophys. Res. Comm. 184: 1378-1385.
    • (1992) Biochem. Biophys. Res. Comm. , vol.184 , pp. 1378-1385
    • Papasawas, S.1    Arkinstall, S.2    Reid, J.3    Payton, M.4
  • 29
    • 0018927330 scopus 로고
    • Chronic cryptococcal meningitis: A new experimental model in rabbits
    • Perfect, J.R., S.D.R. Lang, and D.T. Durack. 1980. Chronic cryptococcal meningitis: A new experimental model in rabbits. Am. J. Pathol. 101: 177-194.
    • (1980) Am. J. Pathol. , vol.101 , pp. 177-194
    • Perfect, J.R.1    Lang, S.D.R.2    Durack, D.T.3
  • 30
    • 0027372019 scopus 로고
    • The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid
    • Perfect, J.R., D.L. Toffaletti, and T.H. Rude. 1993. The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61: 4446-4451.
    • (1993) Infect. Immun. , vol.61 , pp. 4446-4451
    • Perfect, J.R.1    Toffaletti, D.L.2    Rude, T.H.3
  • 31
    • 0020264515 scopus 로고
    • Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans
    • Polacheck, I., V.J. Hearing, and K.J. Kwon-Chung. 1982. Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans. J. Bacteriol. 150: 1212-1220.
    • (1982) J. Bacteriol. , vol.150 , pp. 1212-1220
    • Polacheck, I.1    Hearing, V.J.2    Kwon-Chung, K.J.3
  • 33
    • 0037606443 scopus 로고
    • A simplified assay for cryptococcal phenoloxidase
    • Rhodes, J.C. 1986. A simplified assay for cryptococcal phenoloxidase. Mycologia 78: 867-868.
    • (1986) Mycologia , vol.78 , pp. 867-868
    • Rhodes, J.C.1
  • 36
    • 0025978949 scopus 로고
    • Getting started with yeast
    • Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194: 3-21.
    • (1991) Methods Enzymol. , vol.194 , pp. 3-21
    • Sherman, F.1
  • 37
    • 0027467293 scopus 로고
    • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA
    • Toffaletti, D.L., T.H. Rude, S.A. Johnston, D.T. Durack, and J.R. Perfect. 1993. Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J. Bacteriol. 175: 1405-1411.
    • (1993) J. Bacteriol. , vol.175 , pp. 1405-1411
    • Toffaletti, D.L.1    Rude, T.H.2    Johnston, S.A.3    Durack, D.T.4    Perfect, J.R.5
  • 38
    • 0028233861 scopus 로고
    • Cloning of a Cryptococcus neoformans gene, GPA1, encoding a G-protein α-subunit homolog
    • Tolkacheva, T., P. McNamara, E. Piekarz, and W. Courchesne. 1994. Cloning of a Cryptococcus neoformans gene, GPA1, encoding a G-protein α-subunit homolog. Infect. Immun. 62: 2849-2856.
    • (1994) Infect. Immun. , vol.62 , pp. 2849-2856
    • Tolkacheva, T.1    McNamara, P.2    Piekarz, E.3    Courchesne, W.4
  • 39
    • 84907132073 scopus 로고
    • Melanin-deficient mutants of Cryptococcus neoformans
    • Torres-Guererro, H. and J.C. Edman. 1994. Melanin-deficient mutants of Cryptococcus neoformans. J. Med. Vet. Mycol. 32: 303-313.
    • (1994) J. Med. Vet. Mycol. , vol.32 , pp. 303-313
    • Torres-Guererro, H.1    Edman, J.C.2
  • 41
    • 0029131284 scopus 로고
    • Cryptococcus neoformans melanin and virulence: Mechanism of action
    • Wang, Y., P. Aisen, and A. Casadevall. 1995. Cryptococcus neoformans melanin and virulence: Mechanism of action. Infect. Immun. 63: 3131-3136.
    • (1995) Infect. Immun. , vol.63 , pp. 3131-3136
    • Wang, Y.1    Aisen, P.2    Casadevall, A.3
  • 42
    • 0024966029 scopus 로고
    • The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein
    • Whiteway, M., L. Hougan, D. Dignard, D.Y. Thomas, L. Bell, G.C. Saari, F.J. Grant, P. O'Hara, and V.L. MacKay. 1989. The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein. Cell 56: 467-477.
    • (1989) Cell , vol.56 , pp. 467-477
    • Whiteway, M.1    Hougan, L.2    Dignard, D.3    Thomas, D.Y.4    Bell, L.5    Saari, G.C.6    Grant, F.J.7    O'Hara, P.8    MacKay, V.L.9
  • 43
    • 0029951165 scopus 로고    scopus 로고
    • Dimorphism and haploid fruiting in Cryptococcus neoformans: Association with the α-mating type
    • Wickes, B.L., M.E. Mayorga, U. Edman, and J.C. Edman. 1996. Dimorphism and haploid fruiting in Cryptococcus neoformans: Association with the α-mating type. Proc. Natl. Acad. Sci. 93: 7327-7331.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 7327-7331
    • Wickes, B.L.1    Mayorga, M.E.2    Edman, U.3    Edman, J.C.4
  • 44
    • 0028069606 scopus 로고
    • Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: Identification as a laccase
    • Williamson, P.R. 1994. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: Identification as a laccase. J. Bacteriol. 176: 656-664.
    • (1994) J. Bacteriol. , vol.176 , pp. 656-664
    • Williamson, P.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.