Pka, Ras and RGS Protein Interactions Regulate Activity of AflR, a Zn(II)2Cys6 Transcription Factor in Aspergillus nidulans

Genetics

Volumn 165, Issue 3, 2003, Pages 1095-1104

  Shimizu, Kiminori ^a,c   Hicks, Julie K ^b,d   Huang, Tzu Pi ^a   Keller, Nancy P ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c CHIBA UNIVERSITY   (Japan)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE; GUANINE NUCLEOTIDE BINDING PROTEIN; POLYKETIDE; RAS PROTEIN; RGS PROTEIN; RNA; STERIGMATOCYSTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AFLR; UNCLASSIFIED DRUG; ZINC;

ARTICLE; ASPERGILLUS NIDULANS; BIOSYNTHESIS; ENZYME PHOSPHORYLATION; FUNGUS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; THIN LAYER CHROMATOGRAPHY; TRANSCRIPTION REGULATION;

ASPERGILLUS NIDULANS; BASE SEQUENCE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA PRIMERS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; PHOSPHORYLATION; RAS PROTEINS; RGS PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANSCRIPTION FACTORS;

ASPERGILLUS; EMERICELLA NIDULANS; FUNGI; PROKARYOTA;

EID: 0347622770     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. ALSPAUGH, J. A., J. R. PERFECT and J. HEITMAN, 1997 Cryptocccus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev. 11: 3206-3217.
2. ALSPAUGH, J. A., L. M. CAVALLO, J. R. PERFECT and J. HEITMAN, 2000 RAS1 regulates filamentation, mating and growth at high temperature of Cyptococcus neoformans. Mol. Microbiol. 36: 352-365.
3. BROWN, D. W., J.-H. Yu, H. S. KELKAR, M. FERNANDES, T. C. NESBITT et al., 1996 Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc. Natl. Acad. Sci. USA 93: 1418-1422.
4. CHANG, P.-K., J. W. CARY, D. BHATNAGAR, T. E. CLEVELAND, J. W. BENETT et al., 1993 Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis. Appl. Environ. Microbiol. 59: 3273-3279.
5. CHATTERJEE, T. K., and R. A. FISHER, 2002 RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression. Mol. Cell Biol. 22: 4334-4545.
6. DE VIT, M. J., J. A. WADDLE and M. JOHNSTON, 1997 Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8: 1603-1618.
7. FERNANDES, M., N. P. KELLER and T. H. ADAMS, 1998 Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol. Microbiol. 28: 1355-1365.
8. FILLINGER, S., M.-K. CHAVEROCHE, K. SHIMIZU, N. KELLER, and C. D'ENFERT, 2002 cAMP and ras signaling independently control spore germination in the filamentous fungus Aspergillus nidulans. Mol. Microbiol. 44: 1001-1016.
9. GÖRNER, W., E. DURCHSHLAG, M. T. MARTINEZ-PASTOR, F. ESTRUCH, G. AMMERER et al., 1997 Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12: 586-597.
10. HICKS, J. K., J.-H. Yu, N. P. KELLER, and T. H. ADAMS, 1997 Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. EMBO J. 16: 4916-4923.
11. HIGUCHI, T., Y. WATANABE and M. YAMAMOTO, 2002 Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2P in fission yeast. Mol. Cell. Biol. 22: 1-11.
12. HOHN, T. M., R. KRISHNA and R. H. Proctor, 1999 Characterization of a transcriptional activator controlling trichothecene toxin biosynthesis. Fungal Genet. Biol. 26: 224-235.
13. KATAOKA, T., S. POWERS, C. MCGILL, O. FASANO, J. STRATERN et al., 1984 Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37: 437-445.
14. KELLER, N. P., and T. M. HOHN, 1997 Metabolic pathway gene clusters in filamentous fungi. Fungal Genet. Biol. 21: 17-29.
15. KEMP, B. E., and R. B. PEARSON, 1990 Protein kinase recognition sequence and motifs. Trends Biochem. Sci. 15: 342-346.
16. KENNEDY, J. K., AUCLAIR, S. G., KENDREW, C. PARK, J. C. VEDERAS et al., 1999 Modulation of polyketide synthase activity by accesory proteins during lovastatin biosynthesis. Science 284: 1368-1372.
17. KUNKEL, T. A., K. BEBENEK and J. MCCLARY, 1991 Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol. 204: 125-139.
18. LEE, B. N., and T. H. ADAMS, 1994 Overexpression of flbA, an early regulator of Aspergillus asexual sporulation, leads to activation of brlA and premature initiation of development. Mol. Microbiol. 14: 323-334.
19. MONTENEGRO, E., G. FIERRO, F. J. FERNANDEZ, S. GUTTIEREZ and J. F. MARTIN, 1992 Resolution of chromosomes III and VI of Aspergillus nidulans by pulsed-field gel electrophoresis shows that the penicillin biosynthetic pathway genes pcbAB, pcbC, and pneDE are clustered on chromosome VI (3.0 megabases). J. Bacteriol. 174: 7063-7067.
20. PAYNE, G. A., 1992 Aflatoxin in maize. Crit. Rev. Plant Sci. 10: 423-440.
21. PEARSON, R. B., and B. E. KEMP, 1991 Protein kinase phosporylation site sequences and consensus specificity motifs: tabulations. Methods Enzymol. 200: 62-81.
22. PEÑALVA, M. A., R. T. ROWLANDS and G. TURNER, 1998 The optimization of penicillin biosynthesis in fungi. Trends Biotechnol. 16: 483-489.
23. RAMASWAMY, A., 2002 Ecological analysis of secondary metabolite production in Aspergillus spp. M.S. Thesis, Texas A&M University, College Station, TX.
24. SHIMIZU, K., and N. P. KELLER, 2001 Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157: 591-600.
25. SIM, S. C., 2001 Characterization of genes in the sterigmatocystin gene cluster and thier role in fitness of Asperigillus nidulans. M.S. Thesis, Texas A&M University, College Station, TX.
26. SOM, T., and V. S. KOLAPARTHI, 1994 Developmental decisions in Aspergillus nidulans are modulated by Ras activity. Mol. Cell. Biol. 14: 5333-5348.
27. TAG, A., J. HICKS, G. GARIFULLINA, M. BEREMAND and N. KELLER, 2000 G-protein signaling mediates differential production of toxic secondary metabolites. Mol. Microbiol. 387: 658-665.
28. TAYLOR, W. E., and E. T. YOUNG, 1990 cAMP-dependent phosporylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding. Proc. Natl. Acad. Sci. USA 87: 4098-4102.
29. TODA, T., I. UNO, T. ISHIKAWA, S. POWERS, T. KATAOKA et al., 1985 In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40: 27-36.
30. TODD, R. B., and A. ANDRIANOPOULOS, 1997 Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear DNA binding motif. Fungal Genet. Biol. 21: 388-405.
31. TSUJI, G., Y. KENMOCHI, Y. TAKANO, J. SWEIGARD L. FARRALI, et al., 2000 Novel fungal transcriptional activators, cmr1p of Colletotrichum lagenarium and pig1p of Magnaporthe grisea, contain Cys2His2 zinc finger and Zn(II)2Cys binuclear cluster DNA-binding motifs and regulate transcription of melanin biosynthesis genes in a developmentally specific manner. Mol. Microbiol. 38: 940-954.
32. VERMA, R., R. S. ANNAN, M. J. HUDDLESTON, S. A. CARR, G. REYNARD et al., 1997 Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278: 455-460.
33. WHITMARSH, A. J., and R. J. DAVIS, 2000 Regulation of transcription factor function by phosphorylation. Cell Mol. Life Sci. 57: 1172-1183.
34. WOLOSHUK, C. P., G. L. YOUSIBOVA, J. A. ROLLINS, D. BHATNAGAR and G. A. PAYNE, 1995 Molecular characterization of the afl-1 locus in Aspergillus flavus. Appl. Environ. Microbiol. 61: 3019-3023.
35. YU, J-H., A. E. BUTHCKO, M. FERNANDES, N. P. KELLER, T. J. LEONARD et al., 1996 Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr. Genet. 29: 549-555.