Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport

European Journal of Pharmaceutical Sciences

Volumn 27, Issue 5, 2006, Pages 524-532

  Pratt, Susan ^a   Chen, Victor ^a   Perry III, William I ^a   Starling, James J ^a   Dantzig, Anne H ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Carboxydichlorofluorescein; Drug resistance; Methotrexate; MRP5 (ABCC5); Multidrug resistance protein; Pemetrexed

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CARBOXYDICHLOROFLUORESCEIN; CHLORIDE CHANNEL BLOCKING AGENT; FLOXURIDINE PHOSPHATE; FLUORESCEIN DERIVATIVE; FLUOROURACIL; GLIBENCLAMIDE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; PEMETREXED; PHOSPHODIESTERASE V INHIBITOR; PROBENECID; TREQUINSIN; UNCLASSIFIED DRUG; VERLUKAST; ZAPRINAST;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG TRANSPORT; DRUG UPTAKE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KINETICS; MEMBRANE TRANSPORT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TRANSPORT;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANTIMETABOLITES, ANTINEOPLASTIC; FLUORESCEINS; FLUORESCENT DYES; GLUTAMATES; GUANINE; HELA CELLS; HUMANS; KINETICS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROBENECID; PROPIONATES; QUINOLINES; REPRODUCIBILITY OF RESULTS; STAINING AND LABELING; TRANSFECTION;

EID: 33644847437     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.09.012     Document Type: Article

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