In vitro assessment of acyclovir permeation across cell monolayers in the presence of absorption enhancers

Drug Development and Industrial Pharmacy

Volumn 34, Issue 3, 2008, Pages 279-288

  Shah, Pranav ^a   Jogani, Viral ^a   Mishra, Pushpa ^b   Mishra, Anil Kumar ^b   Bagchi, Tamishraha ^a   Misra, Ambikanandan ^a  

^a M S UNIVERSITY OF BARODA   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

99mTc mannitol; Absorption enhancers; Acyclovir; Caco 2; MDCK; Permeation; TEER

Indexed keywords

ACICLOVIR; CHITOSAN; DIMETHYL BETA CYCLODEXTRIN; DODECYL SULFATE SODIUM; MANNITOL; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN; CELL STRAIN CACO 2; CELL VIABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; MONOLAYER CULTURE; NONHUMAN; PARAMETER; TIGHT JUNCTION;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BETA-CYCLODEXTRINS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL LINE; CELL SURVIVAL; CHITOSAN; DOGS; DRUG SYNERGISM; ELECTRIC IMPEDANCE; EXCIPIENTS; HUMANS; KIDNEY; MANNITOL; PERMEABILITY; SODIUM DODECYL SULFATE;

EID: 41149152352     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040701655952     Document Type: Article

References (41)

1. Anderberg, E. K., & Artursson, P. (1993). Epithelial transport of drugs in cell culture VIII. Effect of sodium dodecyl sulphate on cell membranes and tight junction permeability in human intestinal epithelial (Caco-2) cells. J. Pharm. Sci., 82, 392-398.
2. Artursson, P., Lindmark, T., Davis, S. S., & Ilium, L. (1994). Effect of chitosanon the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res., 11, 1358-1361.
3. Aungst, B. J. (2006). Optimising oral bioavailability of pharmaceutical leads. AAPS Newsmagazine, 9, 3.
4. Balda, M. S., Whitney, J. A., Flores, C., Gonzalez, S., Cereijido, M., & Matter, K. (1996). Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J.Cell Biol., 134, 1031-1049.
5. Bernkop-Schnurch, A. (2000). Chitosan and its derivatives: Potential excipients for per oral peptide delivery systems. Int. J. Pharm., 194, 1-13.
6. Canfield, P. E., Geerdes, A. M., & Molitoris, B. A. (1991). Effect of reversible ATP depletion on tight junction integrity in LLC-PK1 cells. Am. J. Physiol., 261, 1038-1045.
7. De Clercq, E. (1993.) Antivirals for the treatment of herpesvirus infections. J. Antimicrob. Chemother., 32, 121-132.
8. Dodane, V., Khan, M. A., & Merwin, J. R. (1999). Effect of chitosan on epithelial permeability and structure. Int. J. Pharm., 182, 21-32.
9. Eckelman, W. C. (1995). Radiolabeling with technetium-99m to study high-capacity and low capacity biochemical systems. Eur. J. Nucl. Med., 22, 249-263.
10. Elion, G. B., Furman, P. A., Fyfe, J. A., de Miranda, P., Beauchamp, L., & Schaeffer, H. J. (1977). Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc. Natl. Acad. Sci. U.S.A., 74, 5716-5720.
11. Freshney, R. I. (1987). Culture of animal cells: A manual of basic technique. New York: Wiley.
12. Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998). Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occluding. J. Cell Biol., 141, 1539-1550.
13. Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., & Tsukita, S., et al. (1993). Occludin: A novel integral membrane protein localizing at tight junctions. J. Cell Biol., 123, 1777-1788.
14. Hidalgo, I. J. (2001). Assessing the absorption of new pharmaceuticals. Curr. Top. Med. Chem., 1, 385-401.
15. Hovgaard, L., & Brondsted, H. (1995). Drug delivery studies in Caco-2 monolayers. IV. Absorption enhancer effects of cyclodextrins. Pharm. Res., 12, 1328-1332.
16. Irvine, J. D., Takahashi, L., Lockhart, K., Cheong, J., Tolan, J. W., & Selick, H. E., et al. (1999). MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening. J. Pharm. Sci., 88, 28-33.
17. Jain, S. K., Jain, R. K., Chourasia, M. K., Jain, A. K., Chalasani, K. B., & Soni, V., et al. (2005). Design and development of multivesicular liposomal depot delivery system for controlled systemic delivery of acyclovir sodium. AAPS Pharm. Sci., Tech., 6, E35-E41.
18. Junginger, H. E., & Verhoef, J. C. (1998). Macromolecules as safe penetration enhancers for hydrophilic drugs - A fiction? Pharm. Sci. Technol. Today, 1, 370-376.
19. Kerec, M., Bogataj, M., Veranic, P., & Mrhar, A. (2005). Permeability of pig urinary bladder wall: The effect of chitosan and the role of calcium. Eur. J. Pharm. Sci., 25, 113-121.
20. Kotze, A. F., Lueßen, H. L., de Leeuw, B. J., de Boer, A. G., Verhoef, J. C., & Junginger, H. E. (1998). Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J. Control. Release, 51, 35-46.
21. Kotze, A. F., Thanou, M. M., Lue?en, H. L., de Leeuw, B. J., de Boer, A. G., & Verhoef, J. C., et al. (1999). Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environment: In vitro evaluation in intestinal epithelial cells (Caco-2). J. Pharm. Sci., 88, 253-257.
22. Kristl, A., & Tukker, J. J. (1998). Negative correlation of n-octanol/water partition coefficient and transport of some guanine derivatives through rat jejunum in vitro. Pharm. Res., 15, 499-501.
23. Lehr, C. M., Bouwstra, J. A., Schacht, E. H., & Junginger, H. E. (1992). In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm., 78, 43-48.
24. Masson, M., Loftsson, T., Masson, G., & Stefansson, E. (1999). cyclodextrins as permeation enhancers: Some theoretical evaluations and in vitro testing. J. Control. Release, 59, 107-118.
25. Miranda, P. D., & Blum, M. R. (1983). Pharmacokinetics of acyclovir after intravenous and oral administration. J. Antimicrob. Chemother., 12, 29-37.
26. Mishra, A. K., Panwar, P., Hosono, M., Chuttani, K., Mishra, P., & Sharma, R. K., et al. (2004). A new bifunctional chelating agent conjugated with monoclonal antibody and labelled with technetium-99m for targeted scintigraphy: 6-(4-isothiocyanatobenzyl)-5, 7-dioxo-1, 11-(carboxymethyl)-1, 4, 8, 11-tetraazacyclotridecane. J. Drug Target., 12, 559-567.
27. Mukherjee, T., Squillantea, E., Gillespieb, M., & Shao, J. (2004). Transepithelial electrical resistance is not a reliable measurement of the Caco-2 monolayer integrity in Transwell. Drug Deliv., 11, 11-18.
28. Noach, A. B. J., Sakai, M., Blom-Roosemalen, M. C., de Jonge, H. R., de Boer, A. G., & Breimer, D. D. (1994). Effect of anisotonic conditions on the transport of hydrophilic model compounds across monolayers of human colonic cell lines. J. Pharmacol. Exp. Ther., 270, 1373-1380.
29. Ranaldi, G., Marigliano, I., Vespignani, I., Perozzi, G., & Sambuy, Y. (2002). The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line. J. Nutr. Biochem., 13, 157-167.
30. Schaeffer, H. J., Beauchamp, L., de Miranda, P., Elion, G. B., Bauer, D. J., & Collins, P. (1978). 9-(2-Hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature, 272, 583-585.
31. Schipper, N. G. M., Olsson, S., Hoogstraate, J. A., deBoer, A. G., Varum, K. M., & Artursson, P. (1997). Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement. Pharm. Res., 14, 923-929.
32. Shah, P. J, Jogani, V., Bagchi, T., & Misra, A. (2006). Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol. Prog., 22, 186-198.
33. Smith, J., Wood, E., & Dornish, M. (2004). Effect of chitosan on epithelial cell tight junctions. Pharm. Res., 21, 43-49.
34. Stagni, G., Ali, M. E., & Weng, D. (2004). Pharmacokinetics of acyclovir in rabbit skin after IV-bolus, ointment, and iontophoretic administrations. Int. J. Pharm., 274, 201-211.
35. Taub, M. E., Kristensen, L., & Frokjaer, S. (2002). Optimized conditions for MDCK cell permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV. Eur. J. Pharm. Sci., 15, 331-340.
36. Thanou, M. M., Verhoef, J. C., & Junginger, H. E. (2001). Oral absorption and enhancement by chitosan and its derivatives. Adv. Drug Del. Rev., 52, 117-126.
37. Tirumalasetty, P., & Eley, J. G. (2005). Evaluation of dodecylmaltoside as a permeability enhancer for insulin using human carcinoma cells. J. Pharm. Sci., 94, 246-255.
38. Tirumalasetty, P., & Eley, J. G. (2006). Permeability enhancing effects of the alkylglycoside, octylglucoside, on insulin permeation across epithelial membrane in vitro. J. Pharm. Pharmaceut. Sci., 9, 32-39.
39. Tolle-Sander, S., Lentz, K. A., Maeda, D. Y., Coop, A., & Polli, J. E. (2004). Increased acyclovir oral bioavailability via a bile acid conjugate. Mol. Pharm., 1, 40-48.
40. Udata, C., Patel, J., Pal, D., Hejchman, E., Cushman, M., & Mitra, A. K. (2003). Enhanced transport of a novel anti-HIV agent/cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. Int. J. Pharm., 250, 157-168.
41. Vrueh, R. L. A., de Smith, P. L., & Lee, C. P. (1998). Transport of L-valine-acyclovir via the oligopeptide transporter in the human intestinal cell line, Caco-2. J. Pharmacol. Expt., Ther., 286, 1166-1170.