Enhanced transport of a novel anti-HIV agent - Cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers

International Journal of Pharmaceutics

Volumn 250, Issue 1, 2003, Pages 157-168

  Udata, Chandrasekhar ^a   Patel, Jignesh ^b   Pal, Dhananjay ^b   Hejchman, Elzbieta ^c   Cushman, Mark ^c   Mitra, Ashim K ^b  

^a WYETH RESEARCH   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Bile salts; Caco 2 cell monolayers; Cosalane; Cyclodextrins; HIV; Mixed micelles; Permeation enhancers

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BILE SALT; COSALANE; COSALANE BIS(METHYL ESTER); CREMOPHOR; CYCLODEXTRIN DERIVATIVE; DEOXYCHOLATE SODIUM; DIMETHYL BETA CYCLODEXTRIN; DRUG ANALOG; EH 339; EH 355; EH 357; EH 540; MANNITOL; O,O BIS(ACETYL)COSALANE; O,O BIS(ISOBUTYRYL)COSALANE; O,O BIS(PIVALOYL)COSALANE; PENETRATION ENHANCING AGENT; UNCLASSIFIED DRUG; AURINTRICARBOXYLIC ACID; CYCLODEXTRIN; DRUG DERIVATIVE; GLYCEROL;

ARTICLE; CELL CULTURE; CELL DAMAGE; CELL MEMBRANE FLUIDITY; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG FORMULATION; DRUG PENETRATION; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; MICELLE; PRIORITY JOURNAL; CHEMISTRY; PERMEABILITY; SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL;

ANTI-HIV AGENTS; AURINTRICARBOXYLIC ACID; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CYCLODEXTRINS; GLYCEROL; HUMANS; PERMEABILITY; SOLUBILITY;

EID: 0037413385     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00523-9     Document Type: Article

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