Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV

European Journal of Pharmaceutical Sciences

Volumn 15, Issue 4, 2002, Pages 331-340

  Taub, Mitchell E ^a,c   Kristensen, Lisbeth ^a   Frokjaer, Sven ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

BCS; Excipient; MDCK; Permeability; Solubility

Indexed keywords

CELLS; DRUG INFUSION; NEPHELOMETERS; PROTEINS; SOLUBILITY; TURBIDITY;

TURBIDIMETRIC SOLUBILITIES;

DRUG PRODUCTS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ACICLOVIR; ALCOHOL; AMPHOTERICIN B; BOVINE SERUM ALBUMIN; CARBON 14; CHLOROTHIAZIDE; DANAZOL; DIGOXIN; DIMETHYL SULFOXIDE; EXCIPIENT; FUROSEMIDE; KETOPROFEN; MANNITOL; MEFENAMIC ACID; MIDAZOLAM; PARACETAMOL; PHENYTOIN; TAUROCHOLIC ACID; VERAPAMIL; WATER;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL STRAIN; CONTROLLED STUDY; DRUG CLASSIFICATION; DRUG TRANSPORT; MEMBRANE RESISTANCE; MONOLAYER CULTURE; NEPHELOMETRY; NONHUMAN; PH; PHARMACEUTICS; PRIORITY JOURNAL; SOLUBILITY; TURBIDIMETRY;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; EXCIPIENTS; KIDNEY; NEPHELOMETRY AND TURBIDIMETRY; SOLUBILITY;

EID: 0036224723     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00015-5     Document Type: Article

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