Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 21, 2007, Pages 8797-8802

  Guo, Hao Bo ^a   Guo, Hong ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Enzyme catalysis; Potential of mean force; Quantum mechanical molecular mechanical molecular dynamics simulations

Indexed keywords

HISTONE; LYSINE; METHYLTRANSFERASE; MUTANT PROTEIN; PROTEIN LYSINE METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; UNCLASSIFIED DRUG; HISTONE LYSINE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE; PROTON; TYROSINE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENERGY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN METHYLATION; QUANTUM MECHANICS; SIMULATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; METABOLISM; METHYLATION; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SENSITIVITY AND SPECIFICITY;

BINDING SITES; CATALYSIS; COMPUTER SIMULATION; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; METHYLATION; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTONS; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 34547433238     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702981104     Document Type: Article

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