Summary of discussion: In vitro models for investigation of chronic toxicity and reversibility

Toxicology in Vitro

Volumn 13, Issue 4-5, 1999, Pages 853-857

  Combes, R D ^a  

^a RUSSELL AND BURCH HOUSE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTOR; CHRONIC TOXICITY; CONFERENCE PAPER; EYE IRRITATION; HUMAN; IN VITRO STUDY; LONG TERM EXPOSURE; MEASUREMENT; MODEL; NONHUMAN; TOXICITY TESTING;

EID: 0032840842     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00028-4     Document Type: Conference Paper

References (27)

1. TM, in cultured rat hepatocytes and liver fractions. ATLA. 25:1997;641-653.
2. Balls M., Berg N., Bruner L.H., Curren R.D., de Silva O., Earl L.K., Esdaile D.J., Fentem J.H., Liebsch M., Ohno Y., Prinsen M.K., Spielmann H., Worth A. Eye irritation testing: the way forward. The report and recommendations of ECVAM Workshop 34. ATLA. 27. In press:1999.
3. Balls M., Botham P.A., Bruner L.H., Spielmann H. The EC/HO international validation study on alternatives to the Draize eye irritation test. Toxicology in Vitro. 9:1995;871-929.
4. Barile F. A. (1997) Continuous cell line as a model for drug toxicity assessment. In In Vitro Methods in Pharmaceutical Research. Edited by J. V. Castell and M. J. Gómez-Lechon, pp. 34-54. Academic Press, London.
5. Bruner L.H., de Silva O., Earl L.K., Easty D.L., Pape W., Spielmann H. Report on the COLIPA workshop on mechanisms of eye irritation. ATLA. 26:1998;811-820.
6. Cartwright T. (1994) Animal Cells as Bioreactors. pp. 184 Cambridge University Press.
7. Clemedson C., et al. MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals. ATLA. 24:1996;251-272.
8. Clemedson C., et al. MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA. 24:1996;273-311.
9. Clemedson C., et al. MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA. 26:1998;93-129.
10. Clemedson C., et al. MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. ATLA. 26:1998;183-2131.
11. Clothier R.H., Beed M., Samson R., Ward R. An in vitro approach to the evaluation of repeat exposure in the prediction of toxicity. Toxicology in Vitro. 11:1997;679-682.
12. Clothier R., Samson R. Effects of a surfactant in vitro - a method to evaluate changes in cell junctions and cell viability. ATLA. 24:1996;859-865.
13. Forsby A., Pilli F., Walum E. Determination of critical cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell cultures. ATLA. 23:1995;800-811.
14. TM reduction in an epithelial cell line. ATLA. 26:1998;505-522.
15. Hanley A.B., McBride J., Oehlschlager S., Opara E. Use of a flow cell bioreactor as a chronic toxicity model system. Toxicology in Vitro. 13:1999;847-851.
16. Kristen U. and Kappler R. (1995) The pollen tube growth test. In In Vitro Toxicity Testing Protocols - Methods in Molecular Biology. Edited by S. O'Hare and C. K. Atterwill, Vol. 43, pp. 189-198. Humana Press, Totowa, NJ.
17. th International Workshop on In Vitro Toxicology, September, 1998, Winchester, UK.
18. Macdonald C. Development of new animal cell lines by oncogene immortalization. Genetic Engineer and Biotechnologist. 13:1993;121-124.
19. Nordin-Andersson M., Forsby A., Heldring N., DeJongh J., Kjellstrand P., Walum E. Neurite degeneration in differentiated human neuroblastoma cells. Toxicology in Vitro. 12:1998;557-560.
20. Page B., Page M., Noel C. A new fluorimetric assay for cytotoxicity measurements in vitro. International Journal of Oncology. 3:1993;473-476.
21. Ponsoda X., Gómez-Lechon M.J., Castell J. Toxicity and cell density monitoring in monolayer and three-dimensional cultures with the XTT assay. ATLA. 26:1998;331-342.
22. Shaw A.J., Balls M., Clothier R.H., Bateman N.D. Predicting ocular irritancy and recovery from injury using Madin-Darby canine kidney cells. Toxicology in Vitro. 5:1991;569-571.
23. Slamon N.D., Pentreath V.W. A comparison of the acute and chronic effects of antidepressants in cultured C6 and 1321N1 cells. ATLA. 26:1998;303-319.
24. Spielmann H., et al. Results of a validation study in Germany on two in vitro alternatives to the Draize eye irritation test, the HET-CAM test and the 3T3 NRU cytotoxicity test. ATLA. 24:1996;741-858.
25. Tateno C., Yoshizato K. Long-term cultivation of adult rat hepatocytes that undergo multiple cell divisions and express normal parenchymal phenotypes. American Journal of Patholology. 148:1996;383-392.
26. Ward R.K., Hubbard A.W., Sulley H., Garle M.J., Clothier R.H. Human keratinocyte cultures in an in vitro approach for the assessment of surfactant-induced irritation. Toxicology in Vitro. 12:1998;163-173.
27. Ward R.K., Mungall S., Carter J., Clothier R.H. Evaluation of tissue culture insert membrane compatibility in the fluorescein leadage assay. Toxicology in Vitro. 11:1997;761-768.