Prevalence of common disease-associated variants in Asian Indians

BMC Genetics

Volumn 9, Issue , 2008, Pages

  Pemberton, Trevor J ^a   Mehta, Niyati U ^a,b   Witonsky, David ^d   Di Rienzo, Anna ^d   Allayee, Hooman ^a   Conti, David V ^a   Patel, Pragna I ^a,b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ARACHIDONATE 5 LIPOXYGENASE; CALPAIN 10; COMPLEMENT FACTOR H; CYTOCHROME P450 3A5; GLUCOSE TRANSPORTER 4; GLUCOSE TRANSPORTER 4A5; GUANINE NUCLEOTIDE BINDING PROTEIN BETA 3; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PHENYLTHIOUREA; PROTEIN RET; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE NON RECEPTOR TYPE 22; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

ARTICLE; ASIAN; ATHEROSCLEROSIS; BITTER TASTE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; GENE FREQUENCY; GENETIC ASSOCIATION; HAPLOTYPE; HIRSCHSPRUNG DISEASE; HUMAN; HYPERTENSION; INDIAN; LANGUAGE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PREVALENCE; PROSTATE CANCER; RETINA MACULA AGE RELATED DEGENERATION; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN PIGMENTATION; TASTE DISCRIMINATION; UNITED STATES; ETHNOLOGY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; INDIA; MALE; PROSTATE TUMOR; RETINA MACULA DEGENERATION; TASTE;

ATHEROSCLEROSIS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; INDIA; LINKAGE DISEQUILIBRIUM; MACULAR DEGENERATION; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; PROSTATIC NEOPLASMS; TASTE; UNITED STATES;

EID: 41049104558     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-9-13     Document Type: Article

References (110)

1. Population Reference Bureau http://www.prb.org
2. Bittles AH Endogamy, consanguinity and community disease profiles Community Genet 2005, 8(1):17-20. 10.1159/000083332 15767749
3. Mosely C Asher RE Atlas of the World's Languages London, Routledge 2nd 2007.
4. Thapar R A history of India: Volume I. London, UK, Penguin Books. 1990.
5. Taraporevala S Zoroastrians of India. Parsis: A Photographic Journey. Mumbai, India, Good Books 2000.
6. Taraporevala S Parsis: The Zoroastrians of India: A Photographic Journey Mumbai, India, Good Books 2004.
7. Qamar R Ayub Q Mohyuddin A Helgason A Mazhar K Mansoor A Zerjal T Tyler-Smith C Mehdi SQ Y-chromosomal DNA variation in Pakistan Am J Hum Genet 2002, 70(5):1107-1124. 447589 11898125 10.1086/339929
8. Quintana-Murci L Chaix R Wells RS Behar DM Sayar H Scozzari R Rengo C Al-Zahery N Semino O Santachiara-Benerecetti AS Coppa A Ayub Q Mohyuddin A Tyler-Smith C Qasim Mehdi S Torroni A McElreavey K Where west meets east: The complex mtDNA landscape of the southwest and Central Asian corridor Am J Hum Genet 2004, 74(5):827-845. 1181978 15077202 10.1086/ 383236
9. Di Rienzo A Hudson RR An evolutionary framework for common diseases: The ancestral-susceptibility model Trends Genet 2005, 21(11):596-601. 10.1016/j.tig.2005.08.007 16153740
10. Rosenberg NA Mahajan S Gonzales-Quevedo C Nino-Rosales L Ninis V Das P Hedge M Molinari L Zapata G Weber JL Belmont JW Patel PI Low levels of genetic divergence across populations of India. PLoS Genet 2006, 2(12):e215. 1713257 17194221 10.1371/journal.pgen.0020215
11. Wilson PW Christiansen JC Anderson KM Kannel WB Impact of national guidelines for cholesterol risk factor screening. The Framingham Offspring Study. J Am Medical Assoc 1989, 262(1):41-44. 10.1001/ jama.262.1.41
12. Enas EA Prevalence of coronary heart disease and its risk factors in Asian Indian migrants to the United States. Proc Int Symp Atherosclerosis 1991:6-11.
13. Enas EA Mehta J Malignant coronary artery disease in young Asian Indians: Thoughts on pathogenesis, prevention, and therapy. Coronary Artery Disease in Asian Indians (CADI) study. Clin Cardiol 1995, 18(3):131-135. 7743682
14. Enas EA Garg A Davidson MA Nair VM Huet BA Yusuf S Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America. Indian Heart J 1996, 48(4):343-353. 8908818
15. Enas EA Senthilkumar A Coronary Artery Disease in Asian Indians: An Update and Review. The Internet Journal of Cardiology 2001:1-2.
16. Gupta R Prakash H Majumdar S Sharma S Gupta VP Prevalence of coronary heart disease and coronary risk factors in an urban population of Rajasthan. Indian Heart J 1995, 47(4):331-338. 8557274 8557274
17. Deepa M Farooq S Datta M Deepa R Mohan V Prevalence of metabolic syndrome using WHO, ATPIII and IDF definitions in Asian Indians: The Chennai Urban Rural Epidemiology Study (CURES-34) Diabetes Metab Res Rev 2007, 23(2):127-134. 10.1002/dmrr.658 16752431
18. Gupta R Meta-analysis of prevalence of hypertension in India. Indian Heart J 1997, 49(1):43-48. 9130424
19. Kearney PM Whelton M Reynolds K Whelton PK He J Worldwide prevalence of hypertension: A systematic review. J Hypertens 2004, 22(1):11-19. 10.1097/00004872-200401000-00003 15106785
20. Gupta R Misra A Type 2 Diabetes in India: Regional Disparities Br J Diabetes Vasc Dis 2007, 7(1):12-16.
21. Mohan V Deepa M Deepa R Shanthirani CS Farooq S Ganesan A Datta M Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban South India--the Chennai Urban Rural Epidemiology Study (CURES-17) Diabetologia 2006, 49(6):1175-1178. 10.1007/ s00125-006-0219-2 16570158
22. Ramachandran A Snehalatha C Latha E Vijay V Viswanathan M Rising prevalence of NIDDM in an urban population in: India. Diabetologia 1997, 40(2):232-237. 10.1007/s001250050668 9049486
23. Ramachandran A Snehalatha C Kapur A Vijay V Mohan V Das AK Rao PV Yajnik CS Prasanna Kumar KM Nair JD High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey Diabetologia 2001, 44(9):1094-1101. 10.1007/s001250100627 11596662
24. Hirschsprung H Stuhltragheit Neugeborener in Folge von Dilatation und Hypertrophie des Colons Jahrb Kinderheilk 1888, 27:1-7.
25. Watanatittan S Suwatanaviroj A Niramis R Limprutithum T Hirschsprung's disease: Diagnostic experience Bulletin of the Department of Medical Services 1991, 16(1):9-20.
26. Streiff EB Babel J La senescence de la retine. Prog Ophthal 1963, 13:1-75.
27. Krishnaiah S Das T Nirmalan PK Nutheti R Shamanna BR Rao GN Thomas R Risk Factors for Age-Related Macular Degeneration: Findings from the Andhra Pradesh Eye Disease Study in South India Invest Ophthalmol Vis Sci 2005, 46(12):4442-4449. 10.1167/iovs.05-0853 16303932
28. Hsing AW Tsao L Devesa SS International trends and patterns of prostate cancer incidence and mortality Int J Cancer 2000, 85(1):60-67. 10.1002/ (SICI)1097-0215(20000101)85:1<60::AID-IJC11<3.0.CO;2-B 10585584
29. Quinn M Babb P Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: International comparisons BJU International 2002, 90(2):162-173. 10.1046/j.1464-410X.2002.2822.x 12081758
30. Ramachandran A Snehalatha C Abdul Khader OM Joseph TA Viswanathan M Prevalence of childhood diabetes in an urban population in south India. Diabetes Res Clin Pract 1992, 17(3):227-231. 10.1016/ 0168-8227(92)90098-C 1425162
31. Ramachandran A Snehalatha C Krishnaswamy CV Incidence of IDDM in children in urban population in Southern India Diabetes Res Clin Pract 1996, 34(2):79-82. 10.1016/S0168-8227(96)01338-1 9031809
32. Amos AF McCarty DJ Zimmet P The rising global burden of diabetes and its complications: Estimates and projections to the year 2010 Diabet Med 1997, 14(Suppl 5):S1-85. 9450510
33. Garcia-Barcelo MM Sham MH Lui VC Chen BL Song YQ Lee WS Yung SK Romeo G Tam PK Chinese patients with sporadic Hirschsprung's disease are predominantly represented by a single RET haplotype J Med Genet 2003, 40(11):e122. 10.1136/jmg.40.11.e122 14627689
34. Gronberg H Prostate cancer epidemiology Lancet 2003, 361(9360):859-864. 10.1016/S0140-6736(03)12713-4 12642065
35. Kim UK Breslin PAS Reed D Drayna D Genetics of Human Taste Perception J Dent Res 2004, 83(6):448-453. 15153450
36. Meza-Valencia BE de Lorimier AJ Person DA Hirschsprung disease in the U.S. associated Pacific Islands: More common than expected. Hawaii Med J 2005, 64(4):96-98. 15921246
37. Vinereanu D Risk factors for atherosclerotic disease: Present and future Herz 2006, 31(Suppl 3):5-24. 17577934
38. Young JH Evolution of blood pressure regulation in humans Curr Hypertens Rep 2007, 9(1):13-18. 10.1007/s11906-007-0004-8 17362666
39. Klein R Overview of progress in the epidemiology of age-related macular degeneration Ophthalmic Epidemiol 2007, 14(4):184-187. 10.1080/ 09286580701344381 17896295
40. Asleh SA Chowers I Ethnic background as a risk factor for advanced age-related macular degeneration in Israel Isr Med Assoc J 2007, 9(9):656-658. 17939627
41. World Health Organization http://www.who.int/
42. Procopiou M Philippe J The metabolic syndrome and type 2 diabetes: epidemiological figures and country specificities. Cerebrovasc Dis 2005, 20(Suppl 1):2-8. 10.1159/000088231 16276079
43. Wild S Sicree R Roglic G Green A King H Global Prevalence of Diabetes - Estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27(5):1047-1053. 10.2337/diacare.27.5.1047 15111519
44. Motulsky AG Brunzell JD Genetics of coronary atherosclerosis The genetic basis of common diseases New York, NY, Oxford University Press King RA, Rotter JI, Motulsky AG Second edition 2002:105-1126.
45. Gillespie KM Type 1 diabetes: Pathogenesis and prevention Canadian Med Assoc J 2006, 175(2):165-170. 10.1503/cmaj.060244
46. Wolford JK Vozarova de Courten B Genetic basis of type 2 diabetes mellitus: Implications for therapy. Treat Endocrinol 2004, 3(4):257-267. 10.2165/00024677-200403040-00007 16026108
47. Staessen JA Wang J Bianchi G Birkenhager WH Essential hypertension The Lancet 2003, 361(9369):1629-1641. 10.1016/S0140-6736(03)13302-8
48. Bostwick DG Burke HB Djakiew D Euling S Ho S Landolph J Morrison H Sonawane B Shifflett T Waters DJ Timms B Human prostate cancer risk factors Cancer 2004, 101(S10):2371-2490. 10.1002/cncr.20408
49. Chamberlain M Baird P Dirani M Guymer R Unraveling A Complex Genetic Disease: Age-related Macular Degeneration Surv Ophthalmol 2006, 51(6):576-586. 10.1016/j.survophthal.2006.08.003 17134647
50. Thompson EE Kuttab-Boulos H Witonsky D Yang L Roe BA Di Rienzo A CYP3A variation and the evolution of salt-sensitivity variants Am J Hum Genet 2004, 75(6):1059-1069. 1182141 15492926 10.1086/426406
51. Roy JN Lajoie J Zijenah LS Barama A Poirier C Ward BJ Roger M CYP3A5 genetic polymorphims in different ethnic populations. Drug Metab Dispos 2005, 33(7):884-887. 10.1124/dmd.105.003822 15833928
52. Siffert W Forster P Jockel KH Mvere DA Brinkmann B Naber C Crookes R Heyns ADP Epplen JT Fridey JOY Freedman BI Muller N Stolke D Sharma AM Moutaery KA Grosse-Wilde H Buerbaum B Ehrlich T Ahmad HR Horsthemke B Du Toit ED Tiilikainen A Ge J Wang Y Yang D Husing J Rosskopf D Worldwide Ethnic Distribution of the G Protein {beta}3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals J Am Soc Nephrol 1999, 10(9):1921-1930. 10477144
53. Siffert W G protein {beta}3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy Nephrol Dial Transplant 2000, 15(9):1298-1306. 10.1093/ndt/15.9.1298 10978382
54. Rosskopf D Manthey I Siffert W Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics 2002, 12(3):209-220. 10.1097/00008571-200204000-00005 11927836
55. Beeks E Kessels AG Kroon AA van der Klauw MM de Leeuw PW Genetic predisposition to salt-sensitivity: A systematic review. J Hypertens 2004, 22(7):1243-1249. 10.1097/01.hjh.0000125443.28861.0d 15201536
56. Young JH Chang YPC Kim JDO Chretien JP Klag MJ Levine MA Ruff CB Wang NY Chakravarti A Differential Susceptibility to Hypertension Is Due to Selection during the Out-of-Africa Expansion PLoS Genetics 2005, 1(6):e82. 1342636 16429165 10.1371/journal.pgen.0010082
57. Dwyer JH Allayee H Dwyer KM Fan J Wu H Mar R Lusis AJ Mehrabian M Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. New Engl J Med 2004, 350(1):29-37. 10.1056/ NEJMoa025079 14702425
58. Amundadottir LT Sulem P Gudmundsson J Helgason A Baker A Agnarsson BA Sigurdsson A Benediktsdottir KR Cazier JB Sainz J Jakobsdottir M Kostic J Magnusdottir DN Ghosh S Agnarsson K Birgisdottir B Le Roux L Olafsdottir A Blondal T Andresdottir M Gretarsdottir OS Bergthorsson JT Gudbjartsson D Gylfason A Thorleifsson G Manolescu A Kristjansson K Geirsson G Isaksson H Douglas J Johansson JE Balter K Wiklund F Montie JE Yu X Suarez BK Ober C Cooney KA Gronberg H Catalona WJ Einarsson GV Barkardottir RB Gulcher JR Kong A Thorsteinsdottir U Stefansson K A common variant associated with prostate cancer in European and African populations Nat Genet 2006, 38(6):652-658. 10.1038/ng1808 16682969
59. Kim U Jorgenson E Coon H Leppert M Risch N Drayna D Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide Science 2003, 299(5610):1221-1225. 10.1126/ science.1080190 12595690
60. Wooding S Kim UK Bamshad MJ Larsen J Jorde LB Drayna D Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet 2004, 74(4):637-646. 1181941 14997422 10.1086/383092
61. Ranade K Chang MS Ting CT Pei D Hsiao CF Olivier M Pesich R Hebert J Chen YD Dzau VJ Curb D Olshen R Risch N Cox DR Botstein D High-throughput genotyping with single nucleotide polymorphisms Genome Res 2001, 11(7):1262-1268. 311112 11435409
62. Bamshad M Kivisild T Watkins WS Dixon ME Ricker CE Rao BB Naidu JM Prasad BVR Reddy PG Rasanayagam A Papiha SS Villems R Redd AJ Hammer MF Nguyen SV Carroll ML Batzer MA Jorde LB Genetic Evidence on the Origins of Indian Caste Populations Genome Res 2001, 11(6):994-1004. 311057 11381027 10.1101/gr.GR-1733RR
63. Basu A Mukherjee N Roy S Sengupta S Banerjee S Chakraborty M Dey B Roy M Roy B Bhattacharyya NP Roychoudhury S Majumder PP Ethnic India: A Genomic View, With Special Reference to Peopling and Structure Genome Res 2003, 13(10):2277-2290. 403703 14525929 10.1101/gr.1413403
64. Partha PM People of India: Biological diversity and affinities Evolutionary Anthropology: Issues, News, and Reviews 1998, 6(3):100-110. 10.1002/(SICI)1520-6505(1998)6:3<100::AID-EVAN4<3.0.CO;2-I
65. Cann RL Genetic Clues to Dispersal in Human Populations: Retracing the Past from the Present Science 2001, 291(5509):1742-1748. 10.1126/ science.1058948 11249820
66. Gupta R Gupta VP Sarna M Bhatnagar S Thanvi J Sharma V Singh AK Gupta JB Kaul V Prevalence of coronary heart disease and risk factors in an urban Indian population: Jaipur Heart Watch-2 Indian Heart J 2002, 54:59-66. 11999090 11999090
67. Bodhini D Radha V Dhar M Narayani N Mohan V The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians Metabolism 2007, 56(9):1174-1178. 10.1016/j.metabol.2007.04.012 17697858
68. Chandak GR Janipalli CS Bhaskar S Kulkarni SR Mohankrishna P Hattersley AT Frayling TM Yajnik CS Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population Diabetologia 2007, 50(1):63-67. 10.1007/s00125-006-0502-2 17093941
69. Ray D Tomar N Gupta N Goswami R Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians Int J Immunogenet 2006, 33(4):237-240. 10.1111/j.1744-313X.2006.00604.x 16893384
70. Prodi DA Drayna D Forabosco P Palmas MA Maestrale GB Piras D Pirastu M Angius A Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene Chem Senses 2004, 29(8):697-702. 10.1093/chemse/bjh074 15466815
71. Ghoshi AK ABO blood groups and PTC taste sensitivity among the Kota of Nilgiri Hills. Hum Hered 1973, 23(1):78-82. 4742043
72. Hakim SM Baxi AJ Balakrishnan V Kulkarni KV Rao SS Jhala HI Blood groups, secretor status and ability to taste phenylthiocarbamide in some Muslim groups. Hum Hered 1973, 23(1):72-77. 4200438
73. Kapoor AK Seth PK Taste sensitivity to PTC in the Rajputs of Narendra Nagar (Uttar Pradesh, India) Hum Hered 1981, 31(2):124-125. 7228059
74. Mathur VD Mathur S Bahadur B Taste deficiency for phenylthiocarbamide in Mathur Kayasths community of Hyderabad, A.P. Indian J Physiol Pharmacol 1983, 27(2):92-100. 6885137
75. Bhatkar RS Nallulwar SC Katti VA The study of tasters and non-tasters of phenyl-thio-carbamide (PTC) and its relation to blood groups. Indian J Physiol Pharmacol 1989, 33(3):168-170. 2592042
76. Kim UK Drayna D Genetics of individual differences in bitter taste perception: Lessons from the PTC gene Clin Genet 2005, 67(4):275-280. 10.1111/j.1399-0004.2004.00361.x 15733260
77. Wooding S Bufe B Grassi C Howard MT Stone AC Vazquez M Dunn DM Meyerhof W Weiss RB Bamshad MJ Independent evolution of bitter-taste sensitivity in humans and chimpanzees Nature 2006, 440(7086):930-934. 10.1038/ nature04655 16612383
78. Tepper BJ 6-n-Propylthiouracil: A genetic marker for taste, with implications for food preference and dietary habits Am J Hum Genet 1998, 63(5):1271-1276. 1377537 9792854 10.1086/302124
79. Billing J Sherman PW Antimicrobial functions of spices: Why some like it hot Q Rev Biol 1998, 73(1):3-49. 10.1086/420058 9586227
80. Kim U Wooding S Ricci D Jorde LB Drayna D Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci Human Mutation 2005, 26(3):199-204. 10.1002/humu.20203 16086309
81. Sturm RA A golden age of human pigmentation genetics Trends in Genetics 2006, 22(9):464-468. 10.1016/j.tig.2006.06.010 16857289
82. Rosenberg NA Burke T Elo K Feldman MW Freidlin PJ Groenen MAM Hillel J Maki-Tanila A Tixier-Boichard M Vignal A Wimmers K Weigend S Empirical Evaluation of Genetic Clustering Methods Using Multilocus Genotypes From 20 Chicken Breeds Genetics 2001, 159(2):699-713. 1461842 11606545
83. Ramachandran S Rosenberg NA Zhivotovsky LA Feldman MW Robustness of the inference of human population structure: A comparison of X-chromosomal and autosomal microsatellites. Hum Genomics 2004, 1(2):87-97. 15601537
84. Rosenberg NA Calabrese PP Polyploid and multilocus extensions of the Wahlund inequality. Theo Pop Biol 2004, 66(4):381-391. 10.1016/ j.tpb.2004.07.001
85. In KH Asano K Beier D Grobholz J Finn PW Silverman EK Silverman ES Collins T Fischer AR Keith TP Serino K Kim SW De Sanctis GT Yandava C Pillari A Rubin P Kemp J Israel E Busse W Ledford D Murray JJ Segal A Tinkleman D Drazen JM Naturally Occurring Mutations in the Human 5-Lipoxygenase Gene Promoter That Modify Transcription Factor Binding and Reporter Gene Transcription J Clin Invest 1997, 99(5):1130-1137. 507922 9062372 10.1172/JCI119241
86. Brownstein MJ Carpten JD Smith JR Modulation of Non-Templated Nucleotide Addition by Taq DNA Polymerase: Primer Modifications that Facilitate Genotyping. BioTechniques 1996, 20(6):1004-1010. 8780871
87. Scheet P Stephens M A Fast and Flexible Statistical Model for Large-Scale Population Genotype Data: Applications to Inferring Missing Genotypes and Haplotypic Phase Am J Hum Genet 2006, 78(4):629-644. 1424677 16532393 10.1086/502802
88. Stephens M Smith NJ Donnelly P A new statistical method for haplotype reconstruction from population data Am J Hum Genet 2001, 68(4):978-989. 1275651 11254454 10.1086/319501
89. Stephens M Scheet P Accounting for Decay of Linkage Disequilibrium in Haplotype Inference and Missing-Data Imputation Am J Hum Genet 2005, 76(3):449-462. 1196397 15700229 10.1086/428594
90. Stephens M Donnelly P A comparison of bayesian methods for haplotype reconstruction from population genotype data Am J Hum Genet 2003, 73(5):1162-1169. 1180495 14574645 10.1086/379378
91. R Development Core Team R: A language and environment for statistical computing. Vienna, Austria, R Foundation for Statistical Computing 2006 http://www.R-project.org
92. Warnes G Leisch F genetics: Population Genetics. R package version 1.2.0 2005.
93. Weir BS Cockerham CC Estimating F-statitsics for the analysis of population-structure Evolution 1984, 38(6):1358-1370. 10.2307/2408641
94. Akey JM Zhang G Zhang K Jin L Shriver MD Interrogating a High-Density SNP Map for Signatures of Natural Selection Genome Res 2002, 12(12):1805-1814. 187574 12466284 10.1101/gr.631202
95. Goudet J Fstat version 1.2: A computer program to calculate Fstatistics. J Hered 1995, 86(6):485-486.
96. Weir BS Genetic Data Analysis II Sunderland, MA, Sinauer Associates 2nd 1996.
97. Sherry ST Ward MH Kholodov M Baker J Phan L Smigielski EM Sirotkin K dbSNP: The NCBI database of genetic variation Nucl Acids Res 2001, 29(1):308-311. 29783 11125122 10.1093/nar/29.1.308
98. Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine. (dbSNP Build ID: 126). http://www.ncbi.nlm.nih.gov/SNP/
99. Carter K McCaskie P Palmer L JLIN: A java based linkage disequilibrium plotter BMC Bioinformatics 2006, 7(1):60. 1402328 16466584 10.1186/ 1471-2105-7-60
100. Jeunemaitre X Charru A Chatellier G Dumont C Sassano P Soubrier F Menard J Corvol P M235T variant of the human angiotensinogen gene in unselected hypertensive patients. J Hypertens Suppl 1993, 11(5):S80-S81. 10.1097/ 00004872-199312050-00019 8158445
101. Givens RC Lin YS Dowling ALS Thummel KE Lamba JK Schuetz EG Stewart PW Watkins PB CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults J Appl Physiol 2003, 95(3):1297-1300. 12754175
102. Evans JC Frayling TM Cassell PG Saker PJ Hitman GA Walker M Levy JC O'Rahilly S Rao PV Bennett AJ Jones EC Menzel S Prestwich P Simecek N Wishart M Dhillon R Fletcher C Millward A Demaine A Wilkin T Horikawa Y Cox NJ Bell GI Ellard S McCarthy MI Hattersley AT Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet 2001, 69(3):544-552. 1235484 11481585 10.1086/323315
103. Grant SFA Thorleifsson G Reynisdottir I Benediktsson R Manolescu A Sainz J Helgason A Stefansson H Emilsson V Helgadottir A Styrkarsdottir U Magnusson KP Walters GB Palsdottir E Jonsdottir T Gudmundsdottir T Gylfason A Saemundsdottir J Wilensky RL Reilly MP Rader DJ Bagger Y Christiansen C Gudnason V Sigurdsson G Thorsteinsdottir U Gulcher JR Kong A Stefansson K Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 2006, 38(3):320-323. 10.1038/ng1732 16415884
104. Bottini N Musumeci L Alonso A Rahmouni S Nika K Rostamkhani M MacMurray J Meloni GF Lucarelli P Pellecchia M Eisenbarth GS Comings D Mustelin T A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes Nat Genet 2004, 36(4):337-338. 10.1038/ng1323 15004560
105. Haines JL Hauser MA Schmidt S Scott WK Olson LM Gallins P Spencer KL Kwan SY Noureddine M Gilbert JR Schnetz-Boutaud N Agarwal A Postel EA Pericak-Vance MA Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration Science 2005, 308(5720):419-421. 10.1126/science.1110359 15761120
106. Edwards AO Ritter R III Abel KJ Manning A Panhuysen C Farrer LA Complement Factor H Polymorphism and Age-Related Macular Degeneration Science 2005, 308(5720):421-424. 10.1126/science.1110189 15761121
107. Klein RJ Zeiss C Chew EY Tsai JY Sackler RS Haynes C Henning AK SanGiovanni JP Mane SM Mayne ST Bracken MB Ferris FL Ott J Barnstable C Hoh J Complement Factor H Polymorphism in Age-Related Macular Degeneration Science 2005, 308(5720):385-389. 1512523 15761122 10.1126/ science.1109557
108. Rivera; A Fisher SA Fritsche LG Keilhauer CN Lichtner P Meitinger T Weber BHF Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk Hum Mol Genet 2005, 14(21):3227-3236. 10.1093/hmg/ddi353 16174643
109. Emison ES McCallion AS Kashuk CS Bush RT Grice E Lin S Portnoy ME Cutler DJ Green ED Chakravarti A A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk Nature 2005, 434(7035):857-863. 10.1038/nature03467 15829955
110. Lamason RL Mohideen MAPK Mest JR Wong AC Norton HL Aros MC Jurynec MJ Mao X Humphreville VR Humbert JE Sinha S Moore JL Jagadeeswaran P Zhao W Ning G Makalowska I McKeigue PM O'Donnell D Kittles R Parra EJ Mangini NJ Grunwald DJ Shriver MD Canfield VA Cheng KC SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans Science 2005, 310(5755):1782-1786. 10.1126/science.1116238 16357253