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Volumn 99, Issue 4, 2008, Pages 1643-1652

Summation of excitatory and inhibitory synaptic inputs by motoneurons with highly active dendrites

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM; CAT; CONTROLLED STUDY; DECEREBRATION; DENDRITE; DEPOLARIZATION; EXCITATION; IN VIVO STUDY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; SYNAPSE; VOLTAGE CLAMP;

EID: 40949096737     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01253.2007     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 0034589076 scopus 로고    scopus 로고
    • Locus coeruleus and regulation of behavioral flexibility and attention
    • Aston-Jones G, Rajkowski J, Cohen J. Locus coeruleus and regulation of behavioral flexibility and attention. Prog Brain Res 126: 165-182, 2000.
    • (2000) Prog Brain Res , vol.126 , pp. 165-182
    • Aston-Jones, G.1    Rajkowski, J.2    Cohen, J.3
  • 3
    • 33846611864 scopus 로고    scopus 로고
    • Balanced inhibition and excitation drive spike activity in spinal half-centers
    • Berg RW, Alaburda A, Hounsgaard J. Balanced inhibition and excitation drive spike activity in spinal half-centers. Science 315: 390-393, 2007.
    • (2007) Science , vol.315 , pp. 390-393
    • Berg, R.W.1    Alaburda, A.2    Hounsgaard, J.3
  • 4
    • 0036825176 scopus 로고    scopus 로고
    • Integration of synaptic and intrinsic dendritic currents in cat spinal motoneurons
    • Binder MD. Integration of synaptic and intrinsic dendritic currents in cat spinal motoneurons. Brain Res Brain Res Rev 40: 1-8, 2002.
    • (2002) Brain Res Brain Res Rev , vol.40 , pp. 1-8
    • Binder, M.D.1
  • 5
    • 0242472014 scopus 로고    scopus 로고
    • Dendritic L-type calcium currents in mouse spinal motoneurons: Implications for bistability
    • Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM. Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12: 1635-1646, 2000.
    • (2000) Eur J Neurosci , vol.12 , pp. 1635-1646
    • Carlin, K.P.1    Jones, K.E.2    Jiang, Z.3    Jordan, L.M.4    Brownstone, R.M.5
  • 6
    • 1842408933 scopus 로고    scopus 로고
    • Delgad0o-Lezama R, Perrier JF, Nedergaard S, Svirskis G, Hounsgaard J. Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones. J Physiol 504: 97-102, 1997.
    • Delgad0o-Lezama R, Perrier JF, Nedergaard S, Svirskis G, Hounsgaard J. Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones. J Physiol 504: 97-102, 1997.
  • 8
    • 33644859593 scopus 로고    scopus 로고
    • 2+ persistent inward currents in spinal motoneurones: Mode of activation and integration of synaptic inputs
    • 2+ persistent inward currents in spinal motoneurones: mode of activation and integration of synaptic inputs. J Physiol 570: 355-374, 2006.
    • (2006) J Physiol , vol.570 , pp. 355-374
    • Elbasiouny, S.M.1    Bennett, D.J.2    Mushahwar, V.K.3
  • 9
    • 20544459732 scopus 로고    scopus 로고
    • Plasticity of dendritic excitability
    • Frick A, Johnston D. Plasticity of dendritic excitability. J Neurobiol 64: 100-115, 2005.
    • (2005) J Neurobiol , vol.64 , pp. 100-115
    • Frick, A.1    Johnston, D.2
  • 10
    • 0242442847 scopus 로고    scopus 로고
    • Spinal motoneurons: Synaptic inputs and receptor organization
    • edited by Cope TC. London: CRC Press
    • Fyffe REW. Spinal motoneurons: synaptic inputs and receptor organization. In: Motor Biology of the Spinal Cord, edited by Cope TC. London: CRC Press, 2001, p. 21-46.
    • (2001) Motor Biology of the Spinal Cord , pp. 21-46
    • Fyffe, R.E.W.1
  • 11
    • 34548324762 scopus 로고    scopus 로고
    • Effect of localized innervation of the dendritic trees of feline motoneurons on the amplification of synaptic input: A computational study
    • Grande G, Bui TV, Rose PK. Effect of localized innervation of the dendritic trees of feline motoneurons on the amplification of synaptic input: a computational study. J Physiol 583: 611-630, 2007a.
    • (2007) J Physiol , vol.583 , pp. 611-630
    • Grande, G.1    Bui, T.V.2    Rose, P.K.3
  • 12
    • 34447514388 scopus 로고    scopus 로고
    • 2+ channels in motoneurons of different sizes: A computational study
    • 2+ channels in motoneurons of different sizes: a computational study. J Neurophysiol 97: 4023-4035, 2007b.
    • (2007) J Neurophysiol , vol.97 , pp. 4023-4035
    • Grande, G.1    Bui, T.V.2    Rose, P.K.3
  • 14
    • 0034721728 scopus 로고    scopus 로고
    • Diversity and dynamics of dendritic signaling
    • Hausser M, Spruston N, Stuart GJ. Diversity and dynamics of dendritic signaling. Science 290: 739-744, 2000.
    • (2000) Science , vol.290 , pp. 739-744
    • Hausser, M.1    Spruston, N.2    Stuart, G.J.3
  • 15
    • 0024267456 scopus 로고
    • Analysis of effective synaptic currents generated by homonymous Ia afferent fibers in motoneurons of the cat
    • Heckman CJ, Binder MD. Analysis of effective synaptic currents generated by homonymous Ia afferent fibers in motoneurons of the cat. J Neurophysiol 60: 1946-1966, 1988.
    • (1988) J Neurophysiol , vol.60 , pp. 1946-1966
    • Heckman, C.J.1    Binder, M.D.2
  • 16
    • 0026317166 scopus 로고
    • Analysis of Ia-inhibitory synaptic input to cat spinal motoneurons evoked by vibration of antagonist muscles
    • Heckman CJ, Binder MD. Analysis of Ia-inhibitory synaptic input to cat spinal motoneurons evoked by vibration of antagonist muscles. J Neurophysiol 66: 1888-1893, 1991.
    • (1991) J Neurophysiol , vol.66 , pp. 1888-1893
    • Heckman, C.J.1    Binder, M.D.2
  • 17
    • 85038859476 scopus 로고    scopus 로고
    • Advances in measuring active dendritic currents in spinal motoneurons in vivo
    • edited by Cope TC. London: CRC Press
    • Heckman CJ, Lee RH. Advances in measuring active dendritic currents in spinal motoneurons in vivo. In: Motor Neurobiology of the Spinal Cord, edited by Cope TC. London: CRC Press, 2001, p. 89-106.
    • (2001) Motor Neurobiology of the Spinal Cord , pp. 89-106
    • Heckman, C.J.1    Lee, R.H.2
  • 18
    • 0242643730 scopus 로고    scopus 로고
    • Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior
    • Heckman CJ, Lee RH, Brownstone RM. Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior. Trends Neurosci 26: 688-695, 2003.
    • (2003) Trends Neurosci , vol.26 , pp. 688-695
    • Heckman, C.J.1    Lee, R.H.2    Brownstone, R.M.3
  • 19
    • 0028352918 scopus 로고
    • Reduction in postsynaptic inhibition during maintained electrical stimulation of different nerves in the cat hindlimb
    • Heckman CJ, Miller JF, Munson M, Paul KD, Rymer WZ. Reduction in postsynaptic inhibition during maintained electrical stimulation of different nerves in the cat hindlimb. J Neurophysiol 71: 2281-2293, 1994.
    • (1994) J Neurophysiol , vol.71 , pp. 2281-2293
    • Heckman, C.J.1    Miller, J.F.2    Munson, M.3    Paul, K.D.4    Rymer, W.Z.5
  • 20
    • 42249102185 scopus 로고    scopus 로고
    • Heckman CJ, Theiss RD, Johnson MD, Lee RH. Active dendrites markedly enhance input-output gain in motoneurons. Soc Neurosci Abstr 26: 257.212, 2000.
    • Heckman CJ, Theiss RD, Johnson MD, Lee RH. Active dendrites markedly enhance input-output gain in motoneurons. Soc Neurosci Abstr 26: 257.212, 2000.
  • 21
    • 0023780272 scopus 로고
    • Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan
    • Hounsgaard J, Hultborn H, Jespersen B, Kiehn O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 405: 345-367, 1988.
    • (1988) J Physiol , vol.405 , pp. 345-367
    • Hounsgaard, J.1    Hultborn, H.2    Jespersen, B.3    Kiehn, O.4
  • 22
    • 0027162116 scopus 로고
    • Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro
    • Hounsgaard J, Kiehn O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J Physiol 468: 245-259, 1993.
    • (1993) J Physiol , vol.468 , pp. 245-259
    • Hounsgaard, J.1    Kiehn, O.2
  • 23
    • 0345303944 scopus 로고    scopus 로고
    • Key mechanisms for setting the input-output gain across the motoneuron pool
    • Hultborn H, Brownstone RB, Toth TI, Gossard JP. Key mechanisms for setting the input-output gain across the motoneuron pool. Prog Brain Res 143: 77-95, 2004.
    • (2004) Prog Brain Res , vol.143 , pp. 77-95
    • Hultborn, H.1    Brownstone, R.B.2    Toth, T.I.3    Gossard, J.P.4
  • 24
    • 0242624495 scopus 로고    scopus 로고
    • Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current
    • Hultborn H, Denton ME, Wienecke J, Nielsen JB. Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current. J Physiol 552: 945-952, 2003.
    • (2003) J Physiol , vol.552 , pp. 945-952
    • Hultborn, H.1    Denton, M.E.2    Wienecke, J.3    Nielsen, J.B.4
  • 25
    • 33847188064 scopus 로고    scopus 로고
    • Intrinsic electrical properties of spinal motoneurons vary with joint angle
    • Hyngstrom AS, Johnson MD, Miller JF, Heckman CJ. Intrinsic electrical properties of spinal motoneurons vary with joint angle. Nat Neurosci 10: 363-369, 2007.
    • (2007) Nat Neurosci , vol.10 , pp. 363-369
    • Hyngstrom, A.S.1    Johnson, M.D.2    Miller, J.F.3    Heckman, C.J.4
  • 26
  • 28
    • 0024618386 scopus 로고
    • A differential synaptic input to the motor nuclei in triceps surae from the caudal and lateral cutaneous sural nerves
    • LaBella LA, Kehler JP, McCrea DA. A differential synaptic input to the motor nuclei in triceps surae from the caudal and lateral cutaneous sural nerves. J Neurophysiol 61: 291-301, 1989.
    • (1989) J Neurophysiol , vol.61 , pp. 291-301
    • LaBella, L.A.1    Kehler, J.P.2    McCrea, D.A.3
  • 29
    • 0027527405 scopus 로고
    • Declining inhibition elicited in cat lumbar motoneurons by repetitive stimulation of group II muscle afferents
    • Lafleur J, Zytnicki D, Horcholle-Bossavit G, Jami L. Declining inhibition elicited in cat lumbar motoneurons by repetitive stimulation of group II muscle afferents. J Neurophysiol 70: 1805-1810, 1993a.
    • (1993) J Neurophysiol , vol.70 , pp. 1805-1810
    • Lafleur, J.1    Zytnicki, D.2    Horcholle-Bossavit, G.3    Jami, L.4
  • 30
    • 0027452013 scopus 로고
    • Declining inhibition in ipsi- and contralateral lumbar motoneurons during contractions of an ankle extensor muscle in the cat
    • Lafleur J, Zytnicki D, Horcholle-Bossavit G, Jami L. Declining inhibition in ipsi- and contralateral lumbar motoneurons during contractions of an ankle extensor muscle in the cat. J Neurophysiol 70: 1797-1804, 1993b.
    • (1993) J Neurophysiol , vol.70 , pp. 1797-1804
    • Lafleur, J.1    Zytnicki, D.2    Horcholle-Bossavit, G.3    Jami, L.4
  • 31
    • 0029743470 scopus 로고    scopus 로고
    • Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo
    • Lee RH, Heckman CJ. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. J Neurophysiol 76: 2107-2110, 1996.
    • (1996) J Neurophysiol , vol.76 , pp. 2107-2110
    • Lee, R.H.1    Heckman, C.J.2
  • 32
    • 0031813246 scopus 로고    scopus 로고
    • Bistability in spinal motoneurons in vivo: Systematic variations in persistent inward currents
    • Lee RH, Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J Neurophysiol 80: 583-593, 1998a.
    • (1998) J Neurophysiol , vol.80 , pp. 583-593
    • Lee, R.H.1    Heckman, C.J.2
  • 33
    • 0031866154 scopus 로고    scopus 로고
    • Bistability in spinal motoneurons in vivo: Systematic variations in rhythmic firing patterns
    • Lee RH, Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998b.
    • (1998) J Neurophysiol , vol.80 , pp. 572-582
    • Lee, R.H.1    Heckman, C.J.2
  • 34
    • 0033021234 scopus 로고    scopus 로고
    • Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine
    • Lee RH, Heckman CJ. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol 81: 2164-2174, 1999.
    • (1999) J Neurophysiol , vol.81 , pp. 2164-2174
    • Lee, R.H.1    Heckman, C.J.2
  • 35
    • 0034279110 scopus 로고    scopus 로고
    • Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo
    • Lee RH, Heckman CJ. Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. J Neurosci 20: 6734-6740, 2000.
    • (2000) J Neurosci , vol.20 , pp. 6734-6740
    • Lee, R.H.1    Heckman, C.J.2
  • 36
    • 0037252958 scopus 로고    scopus 로고
    • Influence of active dendritic currents on input - output processing in spinal motoneurons in vivo
    • Lee RH, Kuo JJ, Jiang MC, Heckman CJ. Influence of active dendritic currents on input - output processing in spinal motoneurons in vivo. J Neurophysiol 89: 27-39, 2003.
    • (2003) J Neurophysiol , vol.89 , pp. 27-39
    • Lee, R.H.1    Kuo, J.J.2    Jiang, M.C.3    Heckman, C.J.4
  • 37
    • 34447341746 scopus 로고    scopus 로고
    • Apamin-sensitive calcium-activated potassium currents (SK) are activated by persistent calcium currents in rat motoneurons
    • Li X, Bennett DJ. Apamin-sensitive calcium-activated potassium currents (SK) are activated by persistent calcium currents in rat motoneurons. J Neurophysiol 97: 3314-3330, 2007.
    • (2007) J Neurophysiol , vol.97 , pp. 3314-3330
    • Li, X.1    Bennett, D.J.2
  • 38
  • 39
    • 25644439234 scopus 로고    scopus 로고
    • How much afterhyperpolarization conductance is recruited by an action potential? A dynamic-clamp study in cat lumbar motoneurons
    • Manuel M, Meunier C, Donnet M, Zytnicki D. How much afterhyperpolarization conductance is recruited by an action potential? A dynamic-clamp study in cat lumbar motoneurons. J Neurosci 25: 8917-8923, 2005.
    • (2005) J Neurosci , vol.25 , pp. 8917-8923
    • Manuel, M.1    Meunier, C.2    Donnet, M.3    Zytnicki, D.4
  • 40
    • 33750425756 scopus 로고    scopus 로고
    • The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats
    • Manuel M, Meunier C, Donnet M, Zytnicki D. The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats. J Physiol 576: 873-886, 2006.
    • (2006) J Physiol , vol.576 , pp. 873-886
    • Manuel, M.1    Meunier, C.2    Donnet, M.3    Zytnicki, D.4
  • 41
    • 36348990846 scopus 로고    scopus 로고
    • Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons
    • Manuel M, Meunier C, Donnet M, Zytnicki D. Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons. J Neurosci 27: 12977-12988, 2007.
    • (2007) J Neurosci , vol.27 , pp. 12977-12988
    • Manuel, M.1    Meunier, C.2    Donnet, M.3    Zytnicki, D.4
  • 42
    • 0036580846 scopus 로고    scopus 로고
    • Emerging rules for the distributions of active dendritic conductances
    • Migliore M, Shepherd GM. Emerging rules for the distributions of active dendritic conductances. Nat Rev Neurosci 3: 362-370, 2002.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 362-370
    • Migliore, M.1    Shepherd, G.M.2
  • 43
    • 34547768786 scopus 로고    scopus 로고
    • Facilitation of somatic calcium channels can evoke prolonged tail currents in rat hypoglossal motoneurons
    • Moritz AT, Newkirk GS, Powers RK, Binder MD. Facilitation of somatic calcium channels can evoke prolonged tail currents in rat hypoglossal motoneurons. J Neurophysiol 98: 1042-1047, 2007.
    • (2007) J Neurophysiol , vol.98 , pp. 1042-1047
    • Moritz, A.T.1    Newkirk, G.S.2    Powers, R.K.3    Binder, M.D.4
  • 44
    • 0037107161 scopus 로고    scopus 로고
    • Motoneurons have different membrane resistance during fictive scratching and weight support
    • Perreault MC. Motoneurons have different membrane resistance during fictive scratching and weight support. J Neurosci 22: 8259-8265, 2002.
    • (2002) J Neurosci , vol.22 , pp. 8259-8265
    • Perreault, M.C.1
  • 45
    • 0033957714 scopus 로고    scopus 로고
    • Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons
    • Powers RK, Binder MD. Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons. J Neurophysiol 83: 483-500, 2000.
    • (2000) J Neurophysiol , vol.83 , pp. 483-500
    • Powers, R.K.1    Binder, M.D.2
  • 47
    • 0036796628 scopus 로고    scopus 로고
    • Firing rate modulation of motoneurons activated by cutaneous and muscle receptor afferents in the decerebrate cat
    • Prather JF, Clark BD, Cope TC. Firing rate modulation of motoneurons activated by cutaneous and muscle receptor afferents in the decerebrate cat. J Neurophysiol 88: 1867-1879, 2002.
    • (2002) J Neurophysiol , vol.88 , pp. 1867-1879
    • Prather, J.F.1    Clark, B.D.2    Cope, T.C.3
  • 48
    • 0035181265 scopus 로고    scopus 로고
    • Amplification and linear summation of synaptic effects on motoneuron firing rate
    • Prather JF, Powers RK, Cope TC. Amplification and linear summation of synaptic effects on motoneuron firing rate. J Neurophysiol 85: 43-53, 2001.
    • (2001) J Neurophysiol , vol.85 , pp. 43-53
    • Prather, J.F.1    Powers, R.K.2    Cope, T.C.3
  • 49
    • 0142244148 scopus 로고    scopus 로고
    • Firing properties of spinal interneurons during voluntary movement. I. State-dependent regularity of firing
    • Prut Y, Perlmutter SI. Firing properties of spinal interneurons during voluntary movement. I. State-dependent regularity of firing. J Neurosci 23: 9600-9610, 2003.
    • (2003) J Neurosci , vol.23 , pp. 9600-9610
    • Prut, Y.1    Perlmutter, S.I.2
  • 50
    • 0036454492 scopus 로고    scopus 로고
    • Central control of information transmission through the intraspinal arborizations of sensory fibers examined 100 years after Ramon y Cajal
    • Rudomin P. Central control of information transmission through the intraspinal arborizations of sensory fibers examined 100 years after Ramon y Cajal. Prog Brain Res 136: 409-421, 2002.
    • (2002) Prog Brain Res , vol.136 , pp. 409-421
    • Rudomin, P.1
  • 51
    • 0015337411 scopus 로고
    • Membrane potential trajectories between spikes underlying motoneuron rhythmic firing
    • Schwindt PC, Calvin WH. Membrane potential trajectories between spikes underlying motoneuron rhythmic firing. J Neurophysiol 35: 311-325, 1972.
    • (1972) J Neurophysiol , vol.35 , pp. 311-325
    • Schwindt, P.C.1    Calvin, W.H.2
  • 52
    • 0018869558 scopus 로고
    • Properties of a persistent inward current in normal and TEA-injected motoneurons
    • Schwindt PC, Crill WE. Properties of a persistent inward current in normal and TEA-injected motoneurons. J Neurophysiol 43: 1700-1724, 1980.
    • (1980) J Neurophysiol , vol.43 , pp. 1700-1724
    • Schwindt, P.C.1    Crill, W.E.2
  • 53
    • 0019988028 scopus 로고
    • Factors influencing motoneuron rhythmic firing: Results from a voltage-clamp study
    • Schwindt PC, Crill WE. Factors influencing motoneuron rhythmic firing: results from a voltage-clamp study. J Neurophysiol 48: 875-890, 1982.
    • (1982) J Neurophysiol , vol.48 , pp. 875-890
    • Schwindt, P.C.1    Crill, W.E.2
  • 54
    • 0034942206 scopus 로고    scopus 로고
    • Impact of network activities on neuronal properties in corticothalamic systems
    • Steriade M. Impact of network activities on neuronal properties in corticothalamic systems. J Neurophysiol 86: 1-39, 2001.
    • (2001) J Neurophysiol , vol.86 , pp. 1-39
    • Steriade, M.1
  • 55
    • 0028867739 scopus 로고
    • Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons
    • Stuart G, Sakmann B. Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 15: 1065-1076, 1995.
    • (1995) Neuron , vol.15 , pp. 1065-1076
    • Stuart, G.1    Sakmann, B.2


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