Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic α1 agonist methoxamine

Journal of Neurophysiology

Volumn 81, Issue 5, 1999, Pages 2164-2174

  Lee, R H ^a   Heckman, C J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; METHOXAMINE; MONOAMINE; NORADRENALIN; SEROTONIN;

AFTERHYPERPOLARIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; DECEREBRATION; DEPOLARIZATION; DRUG EFFECT; MEMBRANE CURRENT; NERVE CELL; NERVE CONDUCTION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; SPECIES DIFFERENCE; SPIKE; SPINAL CORD MOTONEURON; VOLTAGE CLAMP;

EID: 0033021234     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.81.5.2164     Document Type: Article

References (37)

1. BAKELS, R. AND KERNELL, D. Matching between motoneurone and muscle unit properties in rat medial gastrocnemius. J. Physiol. (Lond.) 463: 307-324, 1993.
2. BALDISSERA, F., HULTBORN, H., AND ILLERT, M. Integration in spinal neuronal systems. In: Handbook of Physiology. The Nervous System. Motor Control. Bethesda: Am. Physiol. Soc., 1981, sect. 1, vol. II, part 1, chapt. 10, p. 509-595.
3. BENNETT, D. J., HULTBORN, H., FEDIRCHUK, B., AND GORASSINI, M. Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats. J. Neurophysiol. 80: 2023-2037, 1998.
4. BINDER, M. D., HECKMAN, C. J., AND POWERS, R. K. The physiological control of motoneuron activity. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. New York: Oxford, 1996, sect. 12, chapt. 1, p. 1-53.
5. 2+-dependent spiking and plateau potentials under pharmacological treatment. J. Neurophysiol. 78: 3371-3385, 1997.
6. + currents is compatible with modalgating hypothesis for sodium channels. J. Neurophysiol. 71: 2562-2565, 1994.
7. BURKE, R. E. Firing patterns of gastrocnemius motor units in the decerebrate cat. J. Physiol. (Lond.) 196: 631-654, 1968.
8. BURKE, R. E. Motor units: anatomy, physiology, and functional organization. In: Handbook of Physiology, The Nervous System. Motor Control. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, part 1, p. 345-422.
9. BURKE, R. E., LEVINE, D. N., TSAIRIS, P., AND ZAJAC, F. E. Physiological types and histochemical profiles in motor units of the cat gastrocnemius. J. Physiol. (Lond.) 234: 723-748, 1973.
10. CONWAY, B. A., HULTBORN, H., KIEHN, O., AND MINTZ, I. Plateau potentials in α-motoneurones induced by intravenous injection of L-DOPA and clonidine in the spinal cat. J. Physiol. (Lond.) 405: 369-384, 1988.
11. FLESHMAN, J. W., MUNSON, J. B., SYPERT, G. W., AND FRIEDMAN, W. A. Rheobase, input resistance, and motor-unit type in medial gastrocnemius motoneurons in the cat. J. Neurophysiol. 46: 1326-1338, 1981.
12. GARDINER, P. F. Physiological properties of motoneurons innervating different muscle unit types in rat gastrocnemius. J. Neurophysiol. 69: 1160-1170, 1993.
13. GUTMAN, A. M. Bistability of dendrites. Int. J. Neural Sys. 1: 291-304, 1991.
14. HECKMAN, C. J., MILLER, J. F., MUNSON, M., PAUL, K. D., AND RYMER, W. Z. Reduction in postsynaptic inhibition during maintained electrical stimulation of different nerves in the cat hindlimb. J. Neurophysiol. 71: 2281-2293, 1994.
15. HENNEMAN, E. AND MENDELL, L. M. Functional organization of motoneuron pool and its inputs. In: Handbook of Physiology, The Nervous System, Motor Control. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, part 1, p. 423-507.
16. HOUNSGAARD, J., HULTBORN, H., JESPERSEN, B., AND KIEHN, O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J. Physiol. (Lond.) 405: 345-367, 1988.
17. HOUNSGAARD, J. AND KIEHN, O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. (Lond.) 414: 265-282, 1989.
18. HOUNSGAARD, J. AND KIEHN, O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J. Physiol. (Lond.) 468: 245-259, 1993.
19. HSIAO, C. F., DEL NEGRO, C. A., TRUEBLOOD, P. R., AND CHANDLER, S. H. Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. J. Neurophysiol. 79: 2847-2856, 1998.
20. HULTBORN, H., KATZ, R., AND MACKEL, R. Distribution of recurrent inhibition within a motor nucleus. II. Amount of recurrent inhibition in motoneurones to fast and slow units. Acta Physiol Scand. 134: 363-374, 1988.
21. LARKMAN, P. M. AND KELLY, J. S. Ionic mechanisms mediating 5-hydroxytryptamine- and noradrenaline-evoked depolarization of adult rat facial motoneurones. J. Physiol. (Lond.) 456: 473-490, 1992.
22. LEE, R. H. AND HECKMAN, C. J. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. J. Neurophysiol. 76: 2107-2110, 1996.
23. LEE, R. H. AND HECKMAN, C. J. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J. Neurophysiol. 80: 583-593, 1998a.
24. LEE, R. H. AND HECKMAN, C. J. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J. Neurophysiol. 80: 572-582, 1998b.
25. LINDSAY, A. D. AND FELDMAN, J. L. Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin, J. Physiol. (Lond.) 461: 213-233, 1993.
26. MATTHEWS, P.B.C. Mammalian muscle receptors and their central actions. Monogr. Physiol. Soc. 23: 1-630, 1972.
27. MISGELD, U., MULLER, W., AND POLDER, H. R. Potentiation and suppression by eserine of muscarinic synaptic transmission in the guinea-pig hippocampal slice. J. Physiol. (Lond.) 409: 191-206, 1989.
28. PARKIS, M. A., BAYLISS, D. A., AND BERGER, A. J. Actions of norephinephrine on rat hypoglossal motoneurons. J. Neurophysiol. 74: 1911-1919, 1996.
29. REKLING, J. C. AND FELDMAN, J. L. Calcium-dependent plateau potentials in rostral ambiguus neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 78: 2483-2492, 1997.
30. RICHTER, D. W., PIERREFICHE, O., LALLEY, P. M., AND POLDER, H. R. Voltage-clamp analysis of neurons within deep layers of the brain. J. Neurosci. Methods 67: 121-123, 1996.
31. SASTRY, B. S. AND SINCLAIR, J. G. Tonic inhibitory influence of a supraspinal monoaminergic system on recurrent inhibition of an extensor monosynaptic reflex. Brain Res. 117: 69-76, 1976.
32. SCHWINDT, P. C. AND CRILL, W. E. Properties of a persistent inward current in normal and TEA-injected motoneurons. J. Neurophysiol. 43: 1700-1724, 1980.
33. SCHWINDT, P. C. AND CRILL, W. E. Factors influencing motoneuron rhythmic firing: results from a voltage-clamp study. J. Neurophysiol. 48: 875-890, 1982.
34. SVIRSKIS, G. AND HOUNSGAARD, J. Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord. J. Neurophysiol. 78: 1740-1742, 1997.
35. SVIRSKIS, G. AND HOUNSGAARD, J. Transmitter regulation of plateau properties in turtle motoneurons. J. Neurophysiol. 79: 45-50, 1998.
36. ZENGEL, J. E., REID, S. A., SYPERT, G. W., AND MUNSON, J. B. Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat. J. Neurophysiol. 53: 1323-1344, 1985.
37. ZHANG, B., WOOTEN, J. F., AND HARRIS-WARRICK, M. Calcium plateau potentials in crab stomatogastric ganglion motor neuron. II. Calcium-activated slow inward current. J. Neurophysiol. 74: 1938-1946, 1995.