Influence of active dendritic currents on input-output processing in spinal motoneurons in vivo

Journal of Neurophysiology

Volumn 89, Issue 1, 2003, Pages 27-39

  Lee, R H ^a   Kuo, J J ^a   Jiang, M C ^a   Heckman, C J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACHILLES TENDON; ARTICLE; CAT; DENDRITE; DEPOLARIZATION; IN VITRO STUDY; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; SYNAPSE;

EID: 0037252958     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00137.2002     Document Type: Article

References (62)

1. Bao H, Bradley RM, and Mistretta CM. Development of intrinsic electrophysiological properties in neurons from the gustatory region of rat nucleus of solitary tract. Brain Res Dev Brain Res 86: 143-154, 1995.
2. Bennett DJ, Hultborn H, Fedirchuk B, and Gorassini M. Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats. J Neurophysiol 80: 2023-2037, 1998.
3. Binder MD, Heckman CJ, and Powers RK. How different afferent inputs control motoneuron discharge and the output of the motoneuron pool. Curr Opin Neurobiol 3: 1028-1034, 1993.
4. Binder MD, Heckman CJ, and Powers RK. The physiological control of motoneuron activity. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems, edited by Rowell LB and Shepherd JT. New York: Oxford, 1996, p. 1-53.
5. Brownstone RM, Gossard J-P, and Hultborn H. Voltage-dependent excitation of motoneurons from spinal locomotor centers in the cat. Exp Brain Res 102: 34-44, 1994.
6. Burke RE. Firing patterns of gastrocnemius motor units in the decerebrate cat. J Physiol (Lond) 196: 631-654, 1968.
7. Carlin KP, Jiang Z, and Brownstone RM. Characterization of calcium currents in functionally mature mouse spinal motoneurons. Eur J Neurosci 12: 1624-1634, 2000a.
8. Carlin KP, Jones KE, Jiang Z, Jordan LM, and Brownstone RM. Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12: 1635-1646, 2000b.
9. Cleland CL, Hayward L, and Rymer WZ. Neural mechanisms underlying the clasp-knife reflex in the cat. II. Stretch-sensitive muscular free nerve endings. J Neurophysiol 64: 1319-1330, 1990.
10. Cleland CL and Rymer WZ. Neural mechanisms underlying the clasp-knife reflex in tha cat. I. Characteristics of the reflex. J Neurophysiol 64: 1303-1318, 1990.
11. Collins DF, Burke D, and Gandevia SC. Large involuntary forces consistent with plateau-like behavior of human motoneurons. J Neurosci 21: 4059-4065, 2001.
12. Collins DF, Burke D, and Gandevia SC. Sustained contractions produced by plateau-like behavior in human motoneurones. J Physiol (Lond) 538: 289-301, 2002.
13. Gorassini M, Bennett DJ, Kiehn O, Eken T, and Hultborn H. Activation patterns of hindlimb motor units in the awake rat and their relation to motoneuron intrinsic properties. J Neurophysiol 82: 709-717, 1999.
14. Gorassini MA, Bennett DJ, and Yang JF. Self-sustained firing of human motor units. Neurosci Lett 247: 13-16, 1998.
15. Gorassini M, Yang JF, Siu M, and Bennett DJ. Intrinsic activation of human motoneurons: possible contribution to motor unit excitation. J Neurophysiol 87: 1850-1858, 2002.
16. Granit R, Kernell D, and Shortess GK. Quantitative aspects of repetitive firing of mammalian motoneurons, caused by injected currents. J Physiol (Lond) 168: 911-931, 1963.
17. Gustafsson B, Linstrom S, and Zangger P. Firing behavior of dorsal spinocerebellar tract neurons. J Physiol (Lond) 275: 321-343, 1978.
18. Hausser M, Spruston N, and Stuart GJ. Diversity and dynamics of dendritic signaling. Science 290: 739-744, 2000.
19. Heckman CJ. Computer simulations of the effects of different synaptic input systems on the steady-state input-output structure of the motoneuron pool. J Neurophysiol 71: 1727-1739, 1994.
20. Heckman CJ and Binder MD. Analysis of effective synaptic currents generated by homonymous 1a afferent fibers in motoneurons of the cat. J Neurophysiol 60: 1946-1966, 1988.
21. Heckman CJ and Binder MD. Neural mechanisms underlying the orderly recruitment of motoneurons. In: The Segmental Motor System, edited by Binder MD and Mendell LM. New York: Oxford, 1990, p. 182-204.
22. Heckman CJ and Binder MD. Computer simulation of the steady-state input-output function of the cat medial gastrocnemius motoneuron pool. J Neurophysiol 65: 952-967, 1991.
23. Heckman CJ and Binder MD. Computer simulations of motoneuron firing rate modulation. J Neurophysiol 69: 1005-1008, 1993a.
24. Heckman CJ and Binder MD. Computer simulations of the effects of different synaptic input systems on motor unit recruitment. J Neurophysiol 70: 1827-1840, 1993b.
25. Heckman CJ, Theiss RD, Johnson MD, and Lee RH. Active dendrites markedly enhance input-output gain in motoneurons. Soc Neurosci Abstr 26: 257.212, 2000.
26. Henneman E and Mendell LM. Functional organization of motoneuron pool and its inputs. In: Handbook of Physiology. The Nervous System. Motor Control. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, p. 423-507.
27. Hornby TG, McDonagh JC, Reinking RM, and Stuart DG. Effects of excitatory modulation on intrinsic properties of turtle motoneurons. J Neurophysiol 88: 86-97, 2002a.
28. Hornby TG, McDonagh JC, Reinking RM, and Stuart DG. Electrophysiological properties of spinal motoneurons in the adult turtle. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 188: 397-408, 2002b.
29. Hounsgaard J, Hultborn H, Jespersen B, and Kiehn O. Bistability of alpha-motoneurons in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol (Lond) 405: 345-367, 1988.
30. Hounsgaard J and Kiehn O. Serotonin-induced bistability of turtle motoneurons caused by a nifedipine-sensitive calcium plateau potential. J Physiol (Lond) 414: 265-282, 1989.
31. Hounsgaard J and Kiehn O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurons in vitro. J Physiol (Lond) 468: 245-259, 1993.
32. Jahnsen H and Llinas R. Electrophysiological properties of guinea pig thalamic neurons: an in vitro study. J Physiol (Lond) 349: 205-226, 1984.
33. Johnston D, Magee JC, Colbert CM, and Cristie BR. Active properties of neuronal dendrites. Annu Rev Neurosci 19: 165-186, 1996.
34. Kernell D. The adaptation and the relation between discharge frequency and current strength of cat lumbosacral motoneurones stimulated by long-lasting injected currents. Acta Physiol Scand 65: 65-73, 1965.
35. Kiehn O and Eken T. Prolonged firing in motor units: evidence of plateau potentials in human motoneurons? J Neurophysiol 78: 3061-3068, 1997.
36. Kudina LP and Alexeeva NL. After-potentials and control of repetitive firing in human motoneurons. Electroenceph Clin Neurophysiol 85: 345-353. 1992.
37. Lacaille JC and Williams S. Membrane properties of interneurons in stratum oriens-alveus of the CA1 region of rat hippocampus in vitro. Neuroscience 36: 349-359, 1990.
38. Lanthorn T, Storm J, and Andersen P. Current-to-frequency transduction in CA1 hippocampal pyramidal cells: slow prepotentials dominate the primary range firing. Exp Brain Res 53: 431-443, 1984.
39. Lee RH and Heckman CJ. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. J Neurophysiol 76: 2107-2110, 1996.
40. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J Neurophysiol 80: 583-593, 1998a.
41. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998b.
42. Lee RH and Heckman CJ. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alphal agonist methoxamine. J Neurophysiol 81: 2164-2174, 1999.
43. Lee RH and Heckman CJ. Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. J Neurosci 20: 6734-6740, 2000.
44. Lee RH and Heckman CJ. Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing. J Neurophysiol 85: 472-475, 2001.
45. Manis PB. Membrane properties and discharge characteristics of guinea pig dorsal cochlear nucleus neurons studied in vitro. J Neurosci 10: 2338-2351, 1990.
46. Matthews PBC. Mammalian muscle receptors and their central actions. In: Monographs of the Physiological Society, edited by Davson H, Greenfield ADM, Whittam R. and Brindley GS. London: Edward Arnold, 1972, p. 1-630.
47. Miller JF, Paul KD, Rymer WZ, and Heckman CJ. Intrathecal 2-amino-7-phophonohetanoic acid (AP-7) attenuates clasp knife reflex in decerebrate cat. Soc Neurosci Abstr 23:1039, 1997.
48. Minami T, Oomura Y, and Sugimori M. Electrophysiological properties and glucose responsiveness of guinea pig ventromedial hypothalamic neurons in vitro. J Physiol (Lond) 380: 127-143, 1986.
49. Perrier JF and Hounsgaard J. Ca(2+)-activated nonselective cationic current [I(CAN)] in turtle motoneurons. J Neurophysiol 82: 730-735, 1999.
50. Powers RK and Binder MD. Effective synaptic current and motoneuron firing rate modulation. J Neurophysiol 74: 793-801, 1995.
51. Powers RK and Binder MD. Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons. J Neurophysiol 83: 483-500, 2000.
52. Powers RK and Binder MD. Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 143: 137-263, 2001.
53. Powers RK, Robinson FR, Konodi MA, and Binder MD. Distribution of rubrospinal synaptic input to cat triceps surae motoneurons. J Neurophysiol 70: 1460-1468, 1993.
54. Prather JF, Powers RK, and Cope TC. Amplification and linear summation of synaptic effects on motoneuron firing rate. J Neurophysiol 85: 43-53, 2001.
55. Redman S. A quantitative approach to the integrative function of dendrites. In: International Review of Physiology: Neurophysiology, edited by Porter R. Baltimore, MD: University Park Press, 1976, p. 1-36.
56. Romaiguère P, Vedel J-P, Pagni S, and Zenatti A. Physiolgical properties of the motor units of the wrist extensor muscles in man. Exp Brain Res 78: 51-61, 1989.
57. + channel on soma and processes of dorsal horn neurones of rat spinal cord. J Physiol (Lond) 503: 371-385, 1997.
58. Schwindt PC and Crill WE. Factors influencing motoneuron rhythmic firing: results from a voltage-clamp study. J Neurophysiol 48: 875-890, 1982.
59. Schwindt PC and Crill WE. Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons. J Neurophysiol 74: 2220-2224, 1995.
60. Schwindt P and Crill W. Equivalence of amplified current flowing from dendrite to soma measured by alteration of repetitive firing and by voltage clamp in layer 5 pyramidal neurons. J Neurophysiol 76: 3731-3739, 1996.
61. Svirskis G and Hounsgaard J. Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord. J Neurophysiol 78: 1740-1742, 1997.
62. Yuste R and Tank DW. Dendritic integration in mammalian neurons, a century after Cajal. Neuron 16: 701-716, 1996.