Bistability in spinal motoneurons in vivo: Systematic variations in persistent inward currents

Journal of Neurophysiology

Volumn 80, Issue 2, 1998, Pages 583-593

  Lee, R H ^a   Heckman, C J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHOXAMINE; NORADRENALIN; SEROTONIN;

AFTERHYPERPOLARIZATION; ANIMAL CELL; ARTICLE; CAT; DECEREBRATION; HYPERPOLARIZATION; HYSTERESIS; MEMBRANE CURRENT; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SPIKE; SPINAL CORD MOTONEURON; VOLTAGE CLAMP;

EID: 0031813246     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.80.2.583     Document Type: Article

References (36)

1. AVERY, R. B. AND JOHNSTON, D. Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. J. Neurosci. 16: 5567-5582, 1996.
2. BAGINSKAS, A., GUTMAN, A., AND SVIRSKIS, G. Bi-stable dendrite in constant electric field: a model analysis. Neuroscience 53: 595-603, 1993.
3. BAYLISS, D. A., UMEMIYA, M., AND BERGER, A. J. Inhibition of N-and P-type calcium currents and the after-hyperpolarization in rat motoneurones by serotonin. J. Physiol. (Lond.) 485: 635-647, 1995.
4. BINDER, M. D., HECKMAN, C. J., AND POWERS, R. K. The physiological control of motoneuron activity. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Washington, DC: Am. Physiol. Soc., 1996, sect. 12, chapt. 1, p. 1-53.
5. 2+-dependent spiking and plateau potentials under pharmacological treatment. J. Neurophysiol. 78: 3371-3385, 1997.
6. BROWNSTONE, R. M., GOSSARD, J. P., AND HULTBORN, H. Voltage-dependent excitation of motoneurones from spinal locomotor centres in the cat. Exp. Brain Res. 102: 34-44, 1994.
7. BURKE, R. E., DUM, R. P., FLESHMAN, J. W., GLENN, L. L., LEV-TOV, A., MJ, O. D., AND PINTER, M. J. A HRP study of the relation between cell size and motor unit type in cat ankle extensor motoneurons. J. Comp. Neurol. 209: 17-28, 1982.
8. CONWAY, B. A., HULTBORN, H., KIEHN, O., AND MINTZ, I. Plateau potentials in alpha-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat. J. Physiol. (Lond.) 405: 369-384, 1988.
9. GUSTAFSSON, B. AND PINTER, M. J. An investigation of threshold properties among cat spinal alpha-motoneurones. J. Physiol. (Lond.) 357: 453-483, 1984.
10. HILLE, B. Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer Associates, 1992.
11. HOUNSGAARD, J., HULTBORN, H., JESPERSEN, B., AND KIEHN, O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J. Physiol. (Lond.) 405: 345-367, 1988.
12. HOUNSGAARD, J. AND KIEHN, O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. (Lond.) 414: 265-282, 1989.
13. HOUNSGAARD, J. AND KIEHN, O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J. Physiol. (Lond.) 468: 245-259, 1993.
14. HOUNSGAARD, J. AND MINTZ, I. Calcium conductance and firing properties of spinal motoneurones in the turtle. J. Physiol. (Lond.) 398: 591-603, 1988.
15. JANKOWSKA, E. Interneuronal relay in spinal pathways from proprioceptors. Prog. Neurobiol. 38: 335-378, 1992.
16. KERNELL, D. AND MONSTER, A. W. Threshold current for repetitive impulse firing in motoneurones innervating muscle fibres of different fatigue sensitivity in the cat. Brain Res. 229: 193-196, 1981.
17. KERNELL, D. AND MONSTER, A. W. Time course and properties of late adaptation in spinal motoneurones of the cat. Exp. Brain Res. 46: 191-196, 1982.
18. KERNELL, D. AND ZWAAGSTRA, B. Input conductance axonal conduction velocity and cell size among hindlimb motoneurones of the cat. Brain Res. 204: 311-326, 1980.
19. LARKMAN, P. M. AND KELLY, J. S. Ionic mechanisms mediating 5-hydroxytryptamine-and noradrenaline-evoked depolarization of adult rat facial motoneurones. J. Physiol. (Lond.) 456: 473-490, 1992.
20. LARKUM, M. E., RIOULT, M. G., AND LUSCHER, H. R. Propagation of action potentials in the dendrites of neurons from rat spinal cord slice cultures. J. Neurophysiol. 75: 154-170, 1996.
21. LEE, R. H. AND HECKMAN, C. J. Dendritic plateau potentials and bistable firing in spinal motoneurons: computer simulation studies. Soc. Neurosci. Abstr. 22: 1845, 1996a.
22. LEE, R. H. AND HECKMAN, C. J. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. J. Neurophysiol. 76: 2107-2110, 1996b.
23. LEE, R. H. AND HECKMAN, C. J. Characteristics of persistent inward currents underlying denderitic plateau potentials in spinal motoneurons. Soc. Neurosci. Abstr. 23: 1302, 1997.
24. LEE, R. H. AND HECKMAN, C. J. Bistability in spinal motoneurons in vivo: systematic variation in rhythmic firing patterns. J. Neurophysiol. 80: 572-582, 1998.
25. LINDSAY, A. D. AND FELDMAN, J. L. Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. J. Physiol. (Lond.) 461: 213-233, 1993.
26. 2+ concentration of hippocampal CA1 pyramidal neurons. J. Neurophysiol. 76: 3460-3470, 1996.
27. PARKIS, M. A., BAYLISS, D. A., AND BERGER, A. J. Actions of norepinephrine on rat hypoglossal motoneurons. J. Neurophysiol. 74: 1911-1919, 1995.
28. REKLING, J. C. AND FELDMAN, J. L. Calcium-dependent plateau potentials in rostral ambiguus neurons in the newborn mouse brain stem in vitro. J. Neurophysiol. 78: 2483-2492, 1997.
29. SAWCZUK, A., POWERS, R. K., AND BINDER, M. D. Spike frequency adaptation studied in hypoglossal motoneurons of the rat. J. Neurophysiol. 73: 1799-1810, 1995.
30. SCHWINDT, P. AND CRILL, W. E. A persistent negative resistance in cat lumbar motoneurons. Brain Res. 120: 173-178, 1977.
31. SCHWINDT, P. C. AND CRILL, W. E. Properties of a persistent inward current in normal and TEA-injected motoneurons. J. Neurophysiol. 43: 1700-1724, 1980.
32. SCHWINDT, P. C. AND CRILL, W. E. Factors influencing motoneuron rhythmic firing: results from a voltage-clamp study. J. Neurophysiol. 48: 875-890, 1982.
33. SVIRSKIS, G. AND HOUNSGAARD, J. Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord. J. Neurophysiol. 78: 1740-1742, 1997.
34. SVIRSKIS, G. AND HOUNSGAARD, J. Transmitter regulation of plateau properties in turtle motoneurons. J. Neurophysiol. 79: 45-50, 1998.
35. ZENGEL, J. E., REID, S. A., SYPERT, G. W., AND MUNSON, J. B. Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat. J. Neurophysiol. 53: 1323-1344, 1985.
36. ZHANG, B. AND HARRIS-WARRICK, R. M. Calcium-dependent plateau potentials in a crab stomatogastric ganglion motor neuron. I. Calcium current and its modulation by serotonin. J. Neurophysiol. 74: 1929-1937, 1995.