Simulation of dendritic Cav1.3 channels in cat lumbar motoneurons: Spatial distribution

Journal of Neurophysiology

Volumn 94, Issue 6, 2005, Pages 3961-3974

  ElBasiouny, Sherif M ^a   Bennett, David J ^a   Mushahwar, Vivian K ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; MEMBRANE PROTEIN; CALCIUM CHANNEL L TYPE;

ALPHA NERVE FIBER; ANIMAL CELL; ARTICLE; CALCIUM CHANNEL CAV1.3; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CAT; CELL INTERACTION; COMPUTER SIMULATION; DENDRITE; HYSTERESIS; LUMBAR SPINAL CORD; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SYNAPTIC MEMBRANE; TRICEPS SURAE MUSCLE; ANIMAL; BACK; BIOLOGICAL MODEL; CELL MEMBRANE POTENTIAL; COMPARATIVE STUDY; CYTOLOGY; ELECTROSTIMULATION; EVALUATION; METHODOLOGY; PATCH CLAMP; PHYSIOLOGY; SPINAL CORD; SYNAPSE; THREE DIMENSIONAL IMAGING;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CATS; COMPUTER SIMULATION; DENDRITES; ELECTRIC STIMULATION; EVALUATION STUDIES; IMAGING, THREE-DIMENSIONAL; LUMBOSACRAL REGION; MEMBRANE POTENTIALS; MODELS, NEUROLOGICAL; MOTOR NEURONS; PATCH-CLAMP TECHNIQUES; SPINAL CORD; SYNAPSES;

EID: 28044433163     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00391.2005     Document Type: Article

References (64)

1. Alvarez FJ, Pearson JC, Harrington D, Dewey D, Torbeck L, and Fyffe RE. Distribution of 5-hydroxytryptamine-immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats. J Comp Neurol 393: 69-83, 1998.
2. Baldissera F, Hultborn H, and Illert M. Integration in spinal neuronal systems. In: Handbook of Physiology. The Nervous System. Motor Control., edited by Brooks V. Bethesda, MD: American Physiological Society, 1981, p. 509-595.
3. Barrett EF, Barrett JN, and Crill WE. Voltage-sensitive outward currents in cat motoneurones. J Physiol 304: 251-276, 1980.
4. Barrett JN and Crill WE. Voltage clamp of cat motoneurone somata: properties of the fast inward current. J Physiol 304: 231-249, 1980.
5. Bennett DJ, Hultborn H, Fedirchuk B, and Gorassini MA. Synaptic Activation of Plateaus in Hindlimb Motoneurons of Decerebrate Cats. J Neurophysiol 80: 2023-2037, 1998.
6. Berger AJ and Takahashi T. Serotonin enhances a low-voltage-activated calcium current in rat spinal motoneurons. J Neurosci 10: 1922-1928, 1990.
7. Binder MD, Heckman CJ, and Powers RK. The physiological control of motoneuron activity. In: Section 12: Exercise: Regulation and Integration of Multiple Systems. New York: Oxford Univ. Press, 1996, p. 3-53, 89-127.
8. 2+-dependent spiking and plateau potentials under pharmacological treatment. J Neurophysiol 78: 3371-3385, 1997.
9. Brannstrom T. Quantitative synaptology of functionally different types of cat medial gastrocnemius alpha-motoneurons. J Comp Neurol 330: 439-454, 1993.
10. Burke RE and Glenn LL. Horseradish peroxidase study of the spatial and electrotonic distribution of group Ia synapses on type-identified ankle extensor motoneurons in the cat. J Comp Neurol 372: 465-485, 1996.
11. Burke RE, Walmsley B, and Hodgson JA. HRP anatomy of group Ia afferent contacts on alpha motoneurones. Brain Res 160: 347-352, 1979.
12. Carlin KP, Jiang Z, and Brownstone RM. Characterization of calcium currents in functionally mature mouse spinal motoneurons. Eur J Neurosci 12: 1624-1634, 2000a.
13. Carlin KP, Jones KE, Jiang Z, Jordan LM, and Brownstone RM. Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12: 1635-1646, 2000b.
14. Clements JD and Redman SJ. Cable properties of cat spinal motoneurones measured by combining voltage clamp, current clamp and intracellular staining. J Physiol 409: 63-87, 1989.
15. Conradi S. Observations on the ultrastructure of the axon hillock and initial axon segment of lumbosacral motoneurons in the cat. Acta Physiol Scand Suppl 332: 65-84, 1969.
16. Conway BA, Hultborn H, Kiehn O, and Mintz I. Plateau potentials in alpha-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat. J Physiol 405: 369-384, 1988.
17. Crill WE. Persistent sodium current in mammalian central neurons. Annu Rev Physiol 58: 349-362, 1996.
18. Crone C, Hultborn H, Kiehn O, Mazieres L, and Wigstrom H. Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat. J Physiol 405: 321-343, 1988.
19. Cullheim S, Fleshman JW, Glenn LL, and Burke RE. Membrane area and dendritic structure in type-identified triceps surae alpha motoneurons. J Comp Neurol 255: 68-81, 1987.
20. ElBasiouny SM and Mushahwar VK. Spatial distribution of low voltage-activated L-type calcium channels in the dendrites of cat lumbar motoneurons. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Online. Program No. 875.7, 2004.
21. Fleshman JW, Segev I, and Burke RE. Electrotonic architecture of type-identified alpha-motoneurons in the cat spinal cord. J Neurophysiol 60: 60-85, 1988.
22. Fyffe RE. Spatial distribution of recurrent inhibitory synapses on spinal motoneurons in the cat. J Neurophysiol 65: 1134-1149, 1991.
23. Glenn LL, Burke RE, Fleshman JW, and Lev-Tov A. Estimates of electrotonic distance of group Ia contacts on cat α-motoneurons: an HRP-morphological study. Soc Neurosci Abstr 8: 995, 1982.
24. Gustafsson B and Pinter MJ. An investigation of threshold properties among cat spinal alpha-motoneurones. J Physiol 357: 453-483, 1984.
25. Gutman AM. Bistability of dendrites. Int J Neural Syst 1: 291-304, 1991.
26. 2+ signaling in dendrites of pyramidal neurons. Biophys J 70: 1069-1081, 1996.
27. Hines M and Carnevale T. The NEURON simulation environment. Neural Comput 9: 1179-1209, 1997.
28. Hochman S and McCrea DA. Effects of chronic spinalization on ankle extensor motoneurons. II. Motoneuron electrical properties. J Neurophysiol 71: 1468-1479, 1994a.
29. Hochman S and McCrea DA. Effects of chronic spinalization on ankle extensor motoneurons. III. Composite Ia EPSPs in motoneurons separated into motor unit types. J Neurophysiol 71: 1480-1490, 1994b.
30. Hounsgaard J, Hultborn H, Jespersen B, and Kiehn O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 405: 345-367, 1988.
31. Hounsgaard J and Kiehn O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J Physiol 414: 265-282, 1989.
32. Hounsgaard J and Kiehn O. Calcium spikes and calcium plateaux evoked by differential polarization in dendrites of turtle motoneurones in vitro. J Physiol 468: 245-259, 1993.
33. Hounsgaard J and Mintz I. Calcium conductance and firing properties of spinal motoneurones in the turtle. J Physiol 398: 591-603, 1988.
34. Johnston D, Magee JC, Colbert CM, and Cristie BR. Active properties of neuronal dendrites. Annu Rev Neurosci 19: 165-186, 1996.
35. Jones KE and Bawa P. Computer simulation of the responses of human motoneurons to composite 1A EPSPs: effects of background firing rate. J Neurophysiol 77: 405-420, 1997.
36. Kellerth JO, Berthold CH, and Conradi S. Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. III. Motoneurons innervating fast-twitch (type FR) units of the gastrocnemius muscle. J Comp Neurol 184: 755-767, 1979.
37. Kuo JJ, Lee RH, Johnson MD, Heckman HM, and Heckman CJ. Active dendritic integration of inhibitory synaptic inputs in vivo. J Neurophysiol 90: 3617-3624, 2003.
38. Lee RH and Heckman CJ. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. J Neurophysiol 76: 2107-2110, 1996.
39. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998a.
40. Lee RH and Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J Neurophysiol 80: 583-593, 1998b.
41. Lee RH and Heckman CJ. Paradoxical effect of QX-314 on persistent inward currents and bistable behavior in spinal motoneurons in vivo. J Neurophysiol 82: 2518-2527, 1999.
42. Lee RH and Heckman CJ. Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. J Neurosci 20: 6734-6740, 2000.
43. Lee RH and Heckman CJ. Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing. J Neurophysiol 85: 472-475, 2001.
44. Li Y and Bennett DJ. Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats. J Neurophysiol 90: 857-869, 2003.
45. McIntyre CC and Grill WM. Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. J Neurophysiol 88: 1592-1604, 2002.
46. Powers RK and Binder MD. Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons. J Neurophysiol 83: 483-500, 2000.
47. Powers RK and Binder MD. Persistent sodium and calcium currents in rat hypoglossal motoneurons. J Neurophysiol 89: 615-624, 2003.
48. Prather JF, Powers RK, and Cope TC. Amplification and linear summation of synaptic effects on motoneuron firing rate. J Neurophysiol 85: 43-53, 2001.
49. Rail W. Distinguishing theoretical synaptic potentials computed for different somadendritic distributions of synaptic input. J Neurophysiol 30: 1138-1168, 1967.
50. Rose PK, Ter-Mikaelian M, and Bui T. Location of L-type calcium channels on spinal motoneurons: insights from compartmental models. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Online, Program No. 856.9, 2002.
51. Rose PK, Ter-Mikaelian M, Bui T, Gushing S, and Bedrossian D. Influence of L-type calcium channels on the input-output properties of spinal motoneurons: insights from compartmental models. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Online, Program No. 496.8, 2003.
52. Schwindt PC and Crill WE. A persistent negative resistance in cat lumbar motoneurons. Brain Res 120: 173-178, 1977.
53. Schwindt PC and Crill WE. Properties of a persistent inward current in normal and TEA-injected motoneurons. J Neurophysiol 43: 1700-1724, 1980a.
54. Schwindt PC and Crill WE. Role of a persistent inward current in motoneuron bursting during spinal seizures. J Neurophysiol 43: 1296-1318, 1980b.
55. Segev I, Fleshman JW, and Burke RE. Computer simulation of group Ia EPSPs using morphologically realistic models of cat alpha-motoneurons. J Neurophysiol 64: 648-660, 1990.
56. 2+ channels responsible for plateau potentials in motoneurons from the lumbar spinal cord of the turtle. Eur J Neurosci 18: 258-266, 2003.
57. Takahashi T and Berger AJ. Direct excitation of rat spinal motoneurones by serotonin. J Physiol 423: 63-76, 1990.
58. Talbot MJ and Sayer RJ. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol 76: 2120-2124, 1996.
59. Taylor AM and Enoka RM. Optimization of input patterns and neuronal properties to evoke motor neuron synchronization. J Comput Neurosci 16: 139-157, 2004a.
60. Taylor AM and Enoka RM. Quantification of the factors that influence discharge correlation in model motor neurons. J Neurophysiol 91: 796-814, 2004b.
61. Wang MY and Dun NJ. 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. J Physiol 430: 87-103, 1990.
62. White SR, Fung SJ, and Barnes CD. Norepinephrine effects on spinal motoneurons. Prog Brain Res 88: 343-350, 1991.
63. v1.3α1 L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J Neurosci 21: 5944-5951, 2001.
64. Yuste R and Tank D. Dendritic integration in mammalian neurons, a century after Cajal. Neuron 16: 701-716, 1996.