Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies

American Journal of Pathology

Volumn 152, Issue 3, 1998, Pages 759-769

  Yu, Wengui ^a   Bozza, Patricia T ^b   Tzizik, Dan M ^a   Gray, Jennifer P ^a   Cassara, Jessica ^a   Dvorak, Ann M ^a   Weller, Peter F ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CARBON 14; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE A2;

ARTICLE; CELL INCLUSION; CELLULAR DISTRIBUTION; CYTOPLASM; CYTOSOL; ENZYME ACTIVITY; ENZYME LOCALIZATION; FAT BODY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ARACHIDONIC ACID; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARBON RADIOISOTOPES; CELL FRACTIONATION; CYTOSOL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; INCLUSION BODIES; LIPID METABOLISM; PHOSPHOLIPASES A; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0031889388     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Dvorak AM, Dvorak HF, Peters SP, Schulman ES, MacGlashan DW Jr, Pyne K, Harvey VS, Galli SJ, Lichtenstein LM: Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. J Immunol 1983, 131:2965-2976
2. 3H]-arachidonic acid incorporated by mast cells, macrophages and other cell types. Prostaglandins, Leukotrienes, and Lipoxins. Edited by Bailey JM. New York, Plenum, 1985, pp 221-239
3. Weller PF, Ackerman SJ, Nicholson-Weller A, Dvorak AM: Cytoplasmic lipid bodies of human neutrophilic leukocytes. Am J Pathol 1989, 135:947-959
4. Weller PF, Dvorak AM: Arachidonic acid incorporation by cytoplasmic lipid bodies of human eosinophils. Blood 1985, 65:1269-1274
5. Weller PF, Ryeom SW, Picard ST, Ackerman SJ, Dvorak AM: Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C. J Cell Biol 1991, 113:137-146
6. Weller PF, Monahan-Earley RA, Dvorak HF, Dvorak AM: Cytoplasmic lipid bodies of human eosinophils: subcellular isolation and analysis of arachidonate incorporation. Am J Pathol 1991, 138:141-148
7. Triggiani M, Oriente A, Seeds MC, Bass DA, Marone G, Chilton FH: Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool. J Exp Med 1995, 182:1181-1190
8. Bozza PT, Payne JL, Morham S, Langenbach R, Smithies O, Weller PF: Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. Proc Natl Acad Sci USA 1996, 93:11091-11096
9. Bozza PT, Payne JL, Goulet JL, Weller PF: Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids. J Exp Med 1996, 183:1515-1525
10. Dvorak AM, Schleimer RP, Dvorak AM, Lichtenstein LM, Weller PF: Human lung mast cell and alveolar macrophage cytoplasmic lipid bodies contain arachidonic acid and prostaglandin endoperoxide synthase (cyclooxygenase), the substrate and enzyme necessary for prostaglandin production. Int Arch Allergy Appl Immunol 1992, 99: 208-217
11. Dvorak AM, Morgan E, Schleimer RP, Ryeom SW, Lichtenstein LM, Weller PF: Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to nonmembrane-bound cytoplasmic lipid bodies in human lung mast cells, alveolar macrophages, type II pneumocytes and neutrophils. J Histochem Cytochem 1992, 40:759-769
12. Dvorak AM, Morgan E, Tzizik DM, Weller PF: Prostaglandin endoperoxide synthase (cyclooxygenase): ultrastructural localization to non-membrane-bound cytoplasmic lipid bodies in human eosinophils and murine 3T3 fibroblasts. Int Arch Allergy Immunol 1994, 105:245-250
13. 2 from a macrophage cell line, RAW 264.7. Biochim Biophys Acta 1988, 963:476-492
14. 2 from the human monocytic cell line U937. Proc Natl Acad Sci USA 1990, 87:7708-7712
15. 2 is a 100-kd protein in human monoblast U937 cells. J Biol Chem 1991, 266:5268-5272
16. 2 that exhibits lysophospholipase activity. J Biol Chem 1991, 266:11366-11371
17. Doerfler ME, Weiss J, Clark JD, Elsbach P: Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2. J Clin Invest 1994, 93:1583-1591
18. Adams PD, Parker PJ: TPA-induced activation of MAP kinase. FEBS Lett 1991, 290:77-82
19. 2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA 1992, 89:6147-6151
20. 2 in human platelets. J Biol Chem 1993, 268:26796-26804
21. 2 in human fibroblasts. J Biol Chem 1992, 267:23451-23454
22. 2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. Proc Natl Acad Sci USA 1993, 90:4475-4479
23. 2 activity. J Biol Chem 1990, 265:4934-4938
24. 2 is phosphorylated and activated by MAP kinase. Cell 1993, 72:269-278
25. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J Biol Chem 1993, 268:1960-1964
26. 2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J Biol Chem 1995, 270:2360-2366
27. 2. J Biol Chem 1994, 269:19480-19487
28. Seth A, Gonzalez FA, Gupta S, Raden DL, Davis RJ: Signal transduction within the nucleus by mitogen-activated protein kinase. J Biol Chem 1992, 267:24796-224804
29. Chen RH, Sarnecki C, Blenis J: Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992, 12:915-927
30. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR: Phosphorylation of c-jun mediated by MAP kinases. Nature 1991, 353: 670-674
31. Beil WJ, Weller PF, Peppercorn MA, Galli SJ, Dvorak AM: Ultrastructural immunogold localization of subcellular sites of TNF-α in colonic Crohn's disease. J Leukocyte Biol 1995, 58:284-298
32. Voetman AA, Weening RS, Hamers MN, Meerhof LJ, Bot AA, Roos D: Phagocytosing human neutrophils inactivate their own granular enzymes. J Clin Invest 1981, 67:1541-1549
33. Canonico PG, Beaufay H, Nyssens-Jadin M: Analytical fractionation of mouse peritoneal macrophages: physical and biochemical properties of subcellular organelles from resident (unstimulated) and cultivated cells. J Reticuloendothel Soc 1978, 24:115-138
34. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:910-917
35. Dugan EA: Analysis of phospholipids by one-dimensional thin-layer chromatography. Liquid Chromatography and HPLC 1985, 3(2): 126-128
36. Kasurinen J, Somerharju P: Metabolism of pyrenyl fatty acids in baby hamster kidney fibroblasts: effect of the acyl chain length. J Biol Chem 1992, 267:6563-6569
37. Radom J, Salvayre R, Maret A, Negre A, Douste-Blazy L: Metabolism of 1-pyrenedecanoic acid and accumulation of neutral fluorescent lipids in cultured fibroblasts of multisystemic lipid storage myopathy. Biochim Biophys Acta 1987, 920:131-139
38. Han J, Lee JD, Bibbs L, Ulevitch RJ: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994, 265:808-811
39. 2 independent of the mitogen-activated protein kinases ERK1/2. J Biol Chem 1995, 270: 14816-14823
40. Suzuki K, Sakata N, Hara M, Kitani A, Harigai M, Hirose W, Kawaguchi Y, Kawagoe M, Nakamura H: Flow cytometric analysis of lipid droplet formation in cells of the human monocytic cell line, U937. Biochem Cell Biol 1991, 69:571-576
41. Cheng M, Boulton TG, Cobb MH: ERK3 is a constitutively nuclear protein kinase. J Biol Chem 1996, 271:8951-8958
42. Jackle S, Beisiegel U, Rinninger F, Buck F, Grigoleit A, Block A, Groger I, Greten H, Windler E: Annexin VI, a marker protein of hepatocytic endosomes. J Biol Chem 1994, 269:1026-1032
43. 2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase. Proc Natl Acad Sci USA 1994, 91:3142-3146
44. 2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J Biol Chem 1995, 270:15359-15367
45. Schievella AR, Regier MK, Smith WL, Lin LL: Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 1995, 270:30749-30754
46. Gonzalez FA, Seth A, Raden DL, Bowman DS, Fay FS, Davis RJ: Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J Cell Biol 1993, 122:1089-1101
47. Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY, Milona N, Knopf JL: A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell 1991, 65:1043-1051
48. Channon JY, Leslie CC: A calcium-dependent mechanism for associating a soluble arachidonyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7. J Biol Chem 1990, 265:5409-5413
49. DeWitt DL, Rollins TE, Day JS, Gauger JA, Smith WL: Orientation of the active site and antigenic determinants of prostaglandin endoperoxide synthase in the endoplasmic reticulum. J Biol Chem 1981, 256:10375-10382
50. Merlie JP, Fagan D, Mudd J, Needleman P: Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J Biol Chem 1988, 263:3550-3553
51. Otto JC, Smith WL: The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum. J Biol Chem 1994, 269:19868-19875
52. 2 to the nuclear fraction upon macrophage activation. Biochem Biophys Res Commun 1993, 196:147-153
53. Brock TG, Paine RR, Peters-Golden M: Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J Biol Chem 1994, 269:22059-22066
54. Woods JW, Evans JF, Ethier D, Scott S, Vickers PJ, Hearn L, Heibein JA, Charleson S, Singer II: 5-Lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 1993, 178:1935-1946
55. Brock TG, McNish RW, Peters-Golden M: Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J Biol Chem 1995, 270: 21652-21658
56. Woods JW, Coffey MJ, Brock TG, Singer II, Peters-Golden M: 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest 1995, 95:2035-2046
57. 4 synthesis and metabolism by neutrophils and granule-free cytoplasts. Biochem J 1986, 233:583-588
58. Bozza PT, Yu W, Penrose JF, Morgan ES, Dvorak AM, Weller PF: Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. J Exp Med 1997, 186:909-920