A sensitive and selective liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of novel trioxane antimalarials in different biomatrices using sample-pooling approach for high throughput pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 864, Issue 1-2, 2008, Pages 52-60

  Singh, Rajendra Pratap ^a,b   Sabarinath, S ^a,c   Singh, Shio Kumar ^a   Gupta, Ram Chandra ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b RANBAXY RESEARCH LABORATORIES   (India)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Biomatrices; Electrospray ionization; Sample pooling; Tandem mass spectrometry; Trioxane antimalarials

Indexed keywords

MONKEY PLASMA; RABBIT PLASMA; TRIOXANE ANTIMALARIALS;

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

BIOASSAY;

ANTIMALARIAL AGENT; TRIOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONKEY; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RABBIT; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS, 1-RING; MACACA MULATTA; MALE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SESQUITERPENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPIRO COMPOUNDS; TANDEM MASS SPECTROMETRY;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 40849130619     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.01.054     Document Type: Article

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