Synthesis and antimalarial activity of 6-cycloalkylvinyl substituted 1,2,4-trioxanes

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 22, 2004, Pages 5745-5752

  Singh, Chandan ^a   Srivastav, Naveen Chandra ^a   Puri, Sunil K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimalarial 1,2,4 trioxane; Artemisinin; Photooxygenation; Plasmodium yoelii

Indexed keywords

3 (1 CYCLOHEXYLVINYL) 1,2,5 TRIOXASPIRO[5.5]UNDECANE; 3 (1 CYCLOPROPYLVINYL) 1,2,5 TRIOXASPIRO[5.5]UNDECANE; 3 (1 CYCLOPROPYLVINYL) 1,2,5 TRIOXASPIRO[5.6]DODECANE; 3 (CYCLOPROPYLCYCLOPROPYLIDENE METHYL) 1,2,5 TRIOXASPIRO[5.5]UNDECANE; 6 (1 CYCLOHEXYLVINYL) 3,3 DIMETHYL[1,2,4]TRIOXANE; 6 (1 CYCLOPROPYLVINYL) 3 PHENYL[1,2,4]TRIOXANE; 6 (1 CYCLOPROPYLVINYL) 3,3 DIMETHYL[1,2,4]TRIOXANE; 6 (CYCLOPROPYLCYCLOPROPYLIDENE METHYL) 3,3 DIMETHYL[1,2,4]TRIOXANE; 8 (1 CYCLOHEXYLVINYL) 6,7,10 TRIOXASPIRO[4.5]DECANE; 8 (1 CYCLOPROPYLVINYL) 6,7,10 TRIOXASPIRO[4.5]DECANE; ANTIMALARIAL AGENT; TRIOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL MOUSE; MASS SPECTROMETRY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PLASMODIUM YOELII; PROTECTION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ANIMALS; ANTIMALARIALS; CYCLOPARAFFINS; EPOXY COMPOUNDS; MICE; PLASMODIUM YOELII; VINYL COMPOUNDS;

PLASMODIUM YOELII;

EID: 6344263386     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.08.042     Document Type: Article

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