LC fluorescence method for multiple synthetic compounds to rapidly create in vivo pharmacokinetic database utilizing 'N-in-One' dosing

Journal of Pharmaceutical and Biomedical Analysis

Volumn 26, Issue 4, 2001, Pages 519-530

  Rajanikanth, M ^a   Gupta, R C ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Cassette dosing; In vivo pharmacokinetics; Liquid chromatography and fluorescence detection; N in One dosing

Indexed keywords

1 (2 ISOPROPYLPHENOXY) 3 [N4 [2'(METHYLPHENYL)PIPERAZINYL]] N1 PROPAN 2 OL; 1 (4 PROPIONYLPHENOXY) 3 [N4 (3',4' DIMETHOXYPHENYL)PIPERAZINYL] N1 PROPAN 2 OL; 1 PHENOXY 3 (N4 PHENYLPIPERAZINYL) N1 PROPANE; DYE; MACROGOL 600; MACROGOL 6000; PIPERAZINE DERIVATIVE; PIPERAZINYL DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG MIXTURE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEAN RESIDENCE TIME; MOLECULE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; PIPERAZINES; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034887375     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(01)00452-6     Document Type: Article

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