A drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling

Genetics

Volumn 178, Issue 2, 2008, Pages 883-901

  Zhao, Tao ^a   Gu, Tingting ^a   Rice, Heather C ^a,c   McAdams, Kathleen L ^a   Roark, Kimberly M ^a,d   Lawson, Kaylan ^a,b   Gauthier, Sebastien A ^a   Reagan, Kathleen L ^a   Hewes, Randall S ^a,b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; INSULIN; PEPTIDE; PROTEINASE; STEROID; TRANSCRIPTION FACTOR GAL4;

ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DROSOPHILA; GENE IDENTIFICATION; GENE INSERTION; GENE LOCUS; GENETIC SCREENING; IMMUNOHISTOCHEMISTRY; METAMORPHOSIS; MOLTING; NEURITE; NEUROSECRETORY CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSPOSON;

ANIMALS; CELL LINEAGE; DNA; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA MELANOGASTER; GENETIC SCREENING; IN SITU HYBRIDIZATION; NEUROSECRETORY SYSTEMS; RNA; STEROIDS; TRANSGENES;

CRUSTACEA; HEXAPODA;

EID: 40849116681     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.107.082487     Document Type: Article

References (112)

1. ABDELILAH-SEYFRIED, S., Y. M. CHAN, C. ZENG, N. J. JUSTICE, S. YOUNGER-SHEPHERD et al., 2000 A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155: 733-752.
2. ALLAN, D. W., S. E. PIERRE, I. MIGUEL- ALIAGA and S. THOR, 2003 Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell 113: 73-86.
3. ARANCIO, O., and M. V. CHAO, 2007 Neurotrophins, synaptic plasticity and dementia. Curr. Opin. Neurobiol. 17: 325-330.
4. ARAVIN, A. A., M. LAGOS-QUINTANA, A. YALCIN, M. ZAVOLAN, D. MARKS et al., 2003 The small RNA profile during Drosophila melanogaster development. Dev. Cell 5: 337-350.
5. BAINBRIDGE, S. P., and M. BOWNES, 1981 Staging the metamorphosis of Drosophila melanogaster. J. Embryol. Exp. Morphol. 66: 57-80.
6. BAKER, J. D., and J. W. TRUMAN, 2002 Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptideinduced tanning and selectively block a stereotyped behavioral program. J. Exp. Biol. 205: 2555-2565.
7. BANTIGNIES, F., R. H. GOODMAN and S. M. SMOLIK, 2000 Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol. Cell. Biol. 20: 9317-9330.
8. BARTHELEMY, C., C. E. HENDERSON and B. PETTMANN, 2004 Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci. 5: 48.
9. BEALL, E. L., J. R. MANAK, S. ZHOU, M. BELL, J. S. LIPSICK et al., 2002 Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature 420: 833-837.
10. BECKSTEAD, R. B., G. LAM and C. S. THUMMEL, 2005 The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol. 6: R99.
11. BELLEN, H. J., R. W. LEVIS, G. LIAO, Y. HE, J. W. CARLSON et al., 2004 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167: 761-781.
12. BEREZIKOV, E., E. CUPPEN and R. H. PLASTERK, 2006 Approaches to microRNA discovery. Nat. Genet. 38(Suppl.): S2-S7.
13. BISWAS, S. C., Y. SHI, A. SPROUL and L. A. GREENE, 2007 Pro-apoptotic Bim induction in response to NGF deprivation requires simultaneous activation of three different death signaling pathways. J. Biol. Chem. 282: 29368-29374.
14. BRENNECKE, J., D. R. HIPFNER, A. STARK, R. B. RUSSELL and S. M. COHEN, 2003 bantam encodes a developmentally regulated micro-RNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113: 25-36.
15. BROWN, H. L., L. CHERBAS, P. CHERBAS and J. W. TRUMAN, 2006 Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila. Development 133: 275-285.
16. BRUN, S., A. RINCHEVAL-ARNOLD, J. COLIN, Y. RISLER, B. MIGNOTTE et al., 2006 The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers. Cell Death Differ. 13: 1752-1762.
17. BRUNET, A., S. R. DATTA and M. E. GREENBERG, 2001 Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 11: 297-305.
18. BURBACH, J. P., S. M. LUCKMAN, D. MURPHY and H. GAINER, 2001 Gene regulation in the magnocellular hypothalamoneurohypophysial system. Physiol. Rev. 81: 1197-1267.
19. CHADFIELD, C. G., and J. C. SPARROW, 1985 Pupation in Drosophila melanogaster and the effect of the lethalcryptocephal mutation. Dev. Genet. 5: 103-114.
20. CHEN, F., and I. REBAY, 2000 split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells. Curr. Biol. 10: 943-946.
21. CHERBAS, L., X. HU, I. ZHIMULEV, E. BELYAEVA and P. CHERBAS, 2003 EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue. Development 130: 271-284.
22. CHOI, Y. J., G. LEE and J. H. PARK, 2006 Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster. Development 133: 2223-2232.
23. CLARK, K. A., and D. M. MCKEARIN, 1996 The Drosophila stonewall gene encodes a putative transcription factor essential for germ cell development. Development 122: 937-950.
24. CLARK, A. C., M. L. DEL CAMPO and J. EWER, 2004 Neuroendocrine control of larval ecdysis behavior in Drosophila: complex regulation by partially redundant neuropeptides. J. Neurosci. 24: 4283-4292.
25. DEMEREC, M., 1994 Biology of Drosophila. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
26. DEWEY, E. M., S. L. MCNABB, J. EWER, G. R. KUO, C. L. TAKANISHI et al., 2004 Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. Curr. Biol. 14: 1208-1213.
27. DIANTONIO, A., A. P. HAGHIGHI, S. L. PORTMAN, J. D. LEE, A. M. AMARANTO et al., 2001 Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature 412: 449-452.
28. DOMINGUEZ, M., J. D. WASSERMAN and M. FREEMAN, 1998 Multiple functions of the EGF receptor in Drosophila eye development. Curr. Biol. 8: 1039-1048.
29. DOROQUEZ, D. B., and I. REBAY, 2006 Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit. Rev. Biochem. Mol. Biol. 41: 339-385.
30. DRAIZEN, T. A., J. EWER and S. ROBINOW, 1999 Genetic and hormonal regulation of the death of peptidergic neurons in the Drosophila central nervous system. J. Neurobiol. 38: 455-465.
31. ENRIGHT, A. J., B. JOHN, U. GAUL, T. TUSCHL, C. SANDER et al., 2003 MicroRNA targets in Drosophila. Genome Biol. 5: R1.
32. EWER, J., and S. E. REYNOLDS, 2002 Neuropeptide control of molting in insects, pp. 1-92 in Hormones, Brain and Behavior in Invertebrates, edited by D. W. PFAFF, A. P. ARNOLD, A. M. ETGEN, S. E. FAHRBACH and R. T. RUBIN. Academic Press, New York.
33. EWER, J., S. C. GAMMIE and J. W. TRUMAN, 1997 Control of insect ecdysis by a positive-feedback endocrine system: roles of eclosion hormone and ecdysis triggering hormone. J. Exp. Biol. 200(Pt. 5): 869-881.
34. FRAENKEL, G., and C. HSIAO, 1965 Bursicon, a hormone which mediates tanning of the cuticle in the adult fly and other insects. J. Insect Physiol. 11: 513-556.
35. GILLEY, J., P. J. COFFER and J. HAM, 2003 FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 162: 613-622.
36. GRUMBLING, G., V. STRELETS and THE FLYBASE CONSORTIUM, 2006 FlyBase: anatomical data, images and queries. Nucleic Acids Res. 34: D484-D488.
37. GRUN, D., Y. L. WANG, D. LANGENBERGER, K. C. GUNSALUS and N. RAJEWSKY, 2005 MicroRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput. Biol. 1: e13.
38. HADORN, E., and H. GLOOR, 1943 Cryptocephal ein spat wirkender Letalfaktor bei Drosophila melanogaster. Rev. Suisse Zool. 50: 256-261.
39. HEGDE, A. N., 2004 Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity. Prog. Neurobiol. 73: 311-357.
40. HEWES, R. S., and J. W. TRUMAN, 1991 The roles of central and peripheral eclosion hormone release in the control of ecdysis behavior in Manduca sexta. J. Comp. Physiol. A 168: 697-707.
41. HEWES, R. S., A. M. SCHAEFER and P. H. TAGHERT, 2000 The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics 155: 1711-1723.
42. HEWES, R. S., D. PARK, S. A. GAUTHIER, A. M. SCHAEFERAND P. H. TAGHERT, 2003 The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila. Development 130: 1771-1781.
43. HEWES, R. S., T. GU, J. A. BREWSTER, C. QU and T. ZHAO, 2006 Regulation of secretory protein expression in mature cells by DIMM, a bHLH neuroendocrine differentiation factor. J. Neurosci. 26: 7860-7869.
44. HODGE, J. J., J. C. CHOI, C. J. O'KANE and L. C. GRIFFITH, 2005 Shaw potassium channel genes in Drosophila. J. Neurobiol. 63: 235-254.
45. s protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron 50: 883-895.
46. KARMARKAR, U. R., and Y. DAN, 2006 Experience-dependent plasticity in adult visual cortex. Neuron 52: 577-585.
47. KAROLCHIK, D., R. BAERTSCH, M. DIEKHANS, T. S. FUREY, A. HINRICHS et al., 2003 The UCSC Genome Browser Database. Nucleic Acids Res. 31: 51-54.
48. KIM, Y. J., D. ZITNAN, C. G. GALIZIA, K. H. CHO and M. E. ADAMS, 2006 A command chemical triggers an innate behavior by sequential activation of multiple peptidergic ensembles. Curr. Biol. 16: 1395-1407.
49. KINCH, G., K. L. HOFFMAN, E. M. RODRIGUES, M. C. ZEE and J. C. WEEKS, 2003 Steroid-triggered programmed cell death of a motoneuron is autophagic and involves structural changes in mitochondria. J. Comp. Neurol. 457: 384-403.
50. KLOOSTERMAN, W. P., and R. H. PLASTERK, 2006 The diverse functions of microRNAs in animal development and disease. Dev. Cell 11: 441-450.
51. KOELLE, M. R., W. S.TALBOT, W. A. SEGRAVES, M. T. BENDER, P. CHERBAS et al., 1991 The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67: 59-77.
52. KRAUT, R., K. MENON and K. ZINN, 2001 A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. Curr. Biol. 11: 417-430.
53. KUANG, B., S. C. WU, Y. SHIN, L. LUO and P. KOLODZIEJ, 2000 split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo. Development 127: 1517-1529.
54. LEAMAN, D., P. Y. CHEN, J. FAK, A. YALCIN, M. PEARCE et al., 2005 Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development. Cell 121: 1097-1108.
55. LEE, T., and L. LUO, 1999 Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22: 451-461.
56. LEE, T., S. MARTICKE, C. SUNG, S. ROBINOW and L. LUO, 2000 Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila. Neuron 28: 807-818.
57. LEVINE, R. B., and J. W. TRUMAN, 1982 Metamorphosis of the insect nervous system: changes in morphology and synaptic interactions of identified neurones. Nature 299: 250-252.
58. LEWIS, P. W., E. L. BEALL, T. C. FLEISCHER, D. GEORLETTE, A. J. LINK et al., 2004 Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18: 2929-2940.
59. LI, X., and R. W. CARTHEW, 2005 A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell 123: 1267-1277.
60. LIU, D. X., and L. A. GREENE, 2001 Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 32: 425-438.
61. LIU, D. X., S. C. BISWAS and L. A. GREENE, 2004 B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage. J. Neurosci. 24: 8720-8725.
62. LUAN, H., W. C. LEMON, N. C. PEABODY, J. B. POHL, P. K. ZELENSKY et al., 2006 Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J. Neurosci. 26: 573-584.
63. LUO, C. W., E. M. DEWEY, S. SUDO, J. EWER, S. Y. HSU et al., 2005 Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Proc. Natl. Acad. Sci. USA 102: 2820-2825.
64. LUO, X., O. PUIG, J. HYUN, D. BOHMANN and H. JASPER, 2007 Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J. 26: 380-390.
65. MCCAULEY, D. W., and M. BRONNER-F RASER, 2006 Importance of SoxE in neural crest development and the evolution of the pharynx. Nature 441: 750-752.
66. MCGOVERN, V. L., C. A. PACAK, S. T. SEWELL, M. L. TURSKI and M. A. SEEGER, 2003 A targeted gain of function screen in the embryonic CNS of Drosophila. Mech. Dev. 120: 1193-1207.
67. MCGUIRE, S. E., P. T. LE, A. J. OSBORN, K. MATSUMOTO and R. L. DAVIS, 2003 Spatiotemporal rescue of memory dysfunction in Drosophila. Science 302: 1765-1768.
68. MCGUIRE, S. E., Z. MAO and R. L. DAVIS, 2004 Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci. STKE 2004: pl6.
69. MCNABB, S. L., J. D. BAKER, J. AGAPITE, H. STELLER, L.M. RIDDIFORD et al., 1997 Disruption of a behavioral sequence by targeted death of peptidergic neurons in Drosophila. Neuron 19: 813-823.
70. MULLER, D., S. J. KUGLER, A. PREISS, D. MAIER and A. C. NAGEL, 2005 Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. Genetics 171: 1137-1152.
71. MUNOZ-DESCALZO, S., J. TEROL and N. PARICIO, 2005 Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling. Dev. Biol. 287: 168-179.
72. NAVARRO, X., M. VIVO and A. VALERO-CABRE, 2007 Neural plasticity after peripheral nerve injury and regeneration. Prog. Neurobiol. 82: 163-201.
73. NIJHOUT, H. F., 1994 Insect Hormones. Princeton University Press, Princeton, NJ.
74. O'BRIEN, M. A., and P. H. TAGHERT, 1998 A peritracheal neuropeptide system in insects: release of myomodulin-like peptides at ecdysis. J. Exp. Biol. 201(Pt. 2): 193-209.
75. PARK, J. H., A. J. SCHROEDER, C. HELFRICH- FORSTER, F. R. JACKSON and J. EWER, 2003 Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior. Development 130: 2645-2656.
76. PENA-RANGEL, M. T., I. RODRIGUEZ and J. R. RIESGO-ESCOVAR, 2002 A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Genetics 160: 1035-1050.
77. RAJEWSKY, N., and N. D. SOCCI, 2004 Computational identification of microRNA targets. Dev. Biol. 267: 529-535.
78. REYNOLDS, S. E., P. H. TAGHERT and J. W. TRUMAN, 1979 Eclosion hormone and bursicon titers and the onset of hormonal responsiveness during the last day of adult development in Manduca sexta (L.). J. Exp. Biol. 78: 77-86.
79. RIDDIFORD, L. M., R. S. HEWES and J. W. TRUMAN, 1994 Dynamics and metamorphosis of an identifiable peptidergic neuron in an insect. J. Neurobiol. 25: 819-830.
80. ROBINOW, S., W. S. TALBOT, D. S. HOGNESS and J. W. TRUMAN, 1993 Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. Development 119: 1251-1259.
81. ROMEO, R. D., and B. S. MCEWEN, 2006 Stress and the adolescent brain. Ann. NY Acad. Sci. 1094: 202-214.
82. RøRTH, P., 1996 A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl. Acad. Sci. USA 93: 12418-12422.
83. RøRTH, P., K. SZABO, A. BAILEY, T. LAVERTY, J. REHM et al., 1998 Systematic gain-of-function genetics in Drosophila. Development 125: 1049-1057.
84. RYOO, H. D., and H. STELLER, 2007 Unfolded protein response in Drosophila: why another model can make it fly. Cell Cycle 6: 830-835.
85. SANTOS, J. G., E. POLLAK, K. H. REXER, L. MOLNAR and C. WEGENER, 2006 Morphology and metamorphosis of the peptidergic Va neurons and the median nerve system of the fruit fly, Drosophila melanogaster. Cell Tissue Res. 326: 187-199.
86. SCHUBIGER, M., A. A. WADE, G. E. CARNEY, J. W. TRUMAN and M. BENDER, 1998 Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis. Development 125: 2053-2062.
87. SEMPERE, L. F., N. S. SOKOL, E. B. DUBROVSKY, E. M. BERGER and V. AMBROS, 2003 Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity. Dev. Biol. 259: 9-18.
88. SHERWOOD, N. T., Q. SUN, M. XUE, B. ZHANG and K. ZINN, 2004 Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. PLoS Biol. 2: e429.
89. SORIANO, F. X., S. PAPADIA, F. HOFMANN, N. R. HARDINGHAM, H. BADING et al., 2006 Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J. Neurosci. 26: 4509-4518.
90. STARK, A., J. BRENNECKE, R. B. RUSSELL and S. M. COHEN, 2003 Identification of Drosophila microRNA targets. PLoS Biol. 1: E60.
91. TAGHERT, P. H., and J. W. TRUMAN, 1982 Identification of the bursicon-containing neurones in abdominal ganglia of the tobacco hornworm, Manduca sexta. J. Exp. Biol. 98: 385-401.
92. TAGHERT, P. H., R. S. HEWES, J. H. PARK, M. A. O'BRIEN, M. HAN et al., 2001 Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila. J. Neurosci. 21: 6673-6686.
93. TALBOT, W. S., E. A. SWYRYD and D. S. HOGNESS, 1993 Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 73: 1323-1337.
94. TELEMAN, A. A., Y. W. CHEN and S. M. COHEN, 2005 Drosophila Melted modulates FOXO and TOR activity. Dev. Cell 9: 271-281.
95. TELEMAN, A. A., S. MAITRA and S. M. COHEN, 2006 Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev. 20: 417-422.
96. THIBAULT, S. T., M. A. SINGER, W. Y. MIYAZAKI, B. MILASH, N. A. DOMPE et al., 2004 A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat. Genet. 36: 283-287.
97. THIERY, J.C., P. CHEMINEAU, X. HERNANDEZ, M. MIGAUDAND B. MALPAUX, 2002 Neuroendocrine interactions and seasonality. Domest. Anim. Endocrinol. 23: 87-100.
98. THOMAS, H. E., H. G. STUNNENBERG and A. F. STEWART, 1993 Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature 362: 471-475.
99. TOMANCAK, P., B. P. BERMAN, A. BEATON, R. WEISZMANN, E. KWAN et al., 2007 Global analysis of patterns of gene expression during Drosophila embryogenesis. Genome Biol. 8: R145.
100. TRINH, L. A., M. D. MCCUTCHEN, M. BONNER-FRASER, S. E. FRASER, L. A. BUMM et al., 2007 Fluorescent in situ hybridization employing the conventional NBT/BCIP chromogenic stain. Biotechniques 42: 756-759.
101. TRUMAN, J. W., 1973 Physiology of insect ecdysis. III. Relationship between the hormonal control of eclosion and tanning in the tobacco hornworm, Manduca sexta. J. Exp. Biol. 57: 805-820.
102. TRUMAN, J. W., 1992 Developmental neuroethology of insect metamorphosis. J. Neurobiol. 23: 1404-1422.
103. TRUMAN, J.W., 1996 Steroid receptors and nervous system metamorphosis in insects. Dev. Neurosci. 18: 87-101.
104. TRUMAN, J. W., W. S. TALBOT, S. E. FAHRBACH and D. S. HOGNESS, 1994 Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development. Development 120: 219-234.
105. TSENG, A. S., and I. K. HARIHARAN, 2002 An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Genetics 162: 229-243.
106. VIAU, V., 2002 Functional cross-talk between the hypothalamic-pituitary-gonadal and -adrenal axes. J. Neuroendocrinol. 14: 506-513.
107. WATTS, R. J., E. D. HOOPFER and L. LUO, 2003 Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron 38: 871-885.
108. WEEKS, J. C., 2003 Thinking globally, acting locally: steroid hormone regulation of the dendritic architecture, synaptic connectivity and death of an individual neuron. Prog. Neurobiol. 70: 421-442.
109. WILLIAMS, D. W., and J. W. TRUMAN, 2005 Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons. Development 132: 3631-3642.
110. YAO, T. P., W. A. SEGRAVES, A. E. ORO, M. MCKEOWN and R. M. EVANS, 1992 Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell 71: 63-72.
111. YAO, T. P., B. M. FORMAN, Z. JIANG, L. CHERBAS, J. D. CHEN et al., 1993 Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature 366: 476-479.
112. ZITNANOVA, I., M. E. ADAMS and D. ZITNAN, 2001 Dual ecdysteroid action on the epitracheal glands and central nervous system preceding ecdysis of Manduca sexta. J. Exp. Biol. 204: 3483-3495.