Lipid composition alters drug action at the nicotinic acetylcholine receptor

Molecular Pharmacology

Volumn 73, Issue 3, 2008, Pages 880-890

  Baenziger, John E ^a   Ryan, Stephen E ^a   Goodreid, Michael M ^a   Vuong, Ngoc Q ^a   Sturgeon, Raymond M ^a   DaCosta, Corrie J B ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ION CHANNEL; MEMBRANE PROTEIN; NEUROTRANSMITTER; NICOTINIC RECEPTOR; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PROCAINE; TETRACAINE; TRYPTOPHAN; TYROSINE;

AGONIST; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG MECHANISM; INFRARED SPECTROMETRY; LIPID ANALYSIS; LIPID BILAYER; LIPID COMPOSITION; LOCAL ANESTHESIA; MEMBRANE BINDING; MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL;

ANESTHETICS, LOCAL; ANIMALS; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; KINETICS; LIPID BILAYERS; LIPIDS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLCHOLINES; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TETRACAINE; TORPEDO;

EID: 40849106628     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.039008     Document Type: Article

References (40)

1. Akk G and Auerbach A (1996) Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophys J 70:2652-2658.
2. Allen JA, Halverson-Tamboli RA, and Rasenick MM (2007) Lipid raft microdomains and neurotransmitter signaling. Nat Rev Neurosci 8:128-140.
3. Arias HR, Bhumireddy P, and Bouzat C (2006) Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors. Int J Biochem Cell Biol 38:1254-1276.
4. Baenziger JE and Chew JP (1997) Desensitization of the nicotinic acetylcholine receptor mainly involves a structural change in solvent-accessible regions of the polypeptide backbone. Biochemistry 36:3617-3624.
5. Baenziger JE, Miller KW, and Rothschild KJ (1992) Incorporation of the nicotinic acetylcholine receptor into planar multilamellar films: characterization by fluorescence and Fourier transform infrared difference spectroscopy. Biophys J 61:983-992.
6. Baenziger JE, Miller KW, and Rothschild KJ (1993) Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein structural changes upon desensitization. Biochemistry 32:5448-5454.
7. Baenziger JE, Morris ML, Darsaut TE, and Ryan SE (2000) Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptor. J Biol Chem 275:777-784.
8. Barrantes FJ (2002) Lipid matters: nicotinic acetylcholine receptor-lipid interactions. Mol Membr Biol 19:277-284.
9. Barrantes FJ (2004) Structural basis for lipid modulation of nicotinic acetylcholine receptor function. Brain Res Rev 47:71-95.
10. Barth A (2000) The infrared absorption of amino acid side chains. Prog Biophys Mol Biol 74:141-173.
11. Blanchard SG, Elliott J, and Raftery MA (1979) Interaction of local anesthetics with Torpedo californica membrane-bound acetylcholine receptor. Biochemistry 18:5880-5885.
12. 3H]carbamoylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor. Biochemistry 19:5344-5353.
13. Brudler R, Rammelsberg R, Woo TT, Getzoff ED, and Gerwert K (2001) Structure of the I1 early intermediate of photoactive yellow protein by FTIR spectroscopy. Nat Struct Biol 8:265-270.
14. Brusés JL, Chauvet N, and Rutishauser U (2001) Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons. J Neurosci 21:504-512.
15. daCosta CJB, Kaiser DE, and Baenziger JE (2005) Role of glycosylation and membrane environment in nicotinic acetylcholine receptor stability. Biophys J 88:1755-1764.
16. daCosta CJB, Ogrel AA, McCardy EA, Blanton MP, and Baenziger JE (2002) Lipid-protein interactions at the nicotinic acetylcholine receptor. A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers. J Biol Chem 277:201-208.
17. Fong TM and McNamee MG (1986) Correlation between acetylcholine receptor function and structural properties of membranes. Biochemistry 25:830-840.
18. Hill DG and Baenziger JE (2006) The net orientation of nicotinic receptor transmembrane alpha-helices in the resting and desensitized states. Biophys J 91:705-714.
19. Jackson M and Mantsch HH (1995) The use and misuse of FTIR spectroscopy in the determination of protein structure. Crit Rev Biochem Mol Biol 30:95-120.
20. Kötting C and Gerwert K (2005) Proteins in action monitored by time-resolved FTIR spectroscopy. Chem Phys Chem 6:881-888.
21. Krodel EK, Beckman RA, and Cohen JB (1979) Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue. Mol Pharmacol 15:294-312.
22. Lee AG (2004) How lipids affect the activities of integral membrane proteins. Biochim Biophys Acta 1666:62-87.
23. Lester HA, Dibas MI, Dahan DS, Leite JF, and Dougherty DA (2004) Cys-loop receptors: new twists and turns. Trends Neurosci 27:329-336.
24. McMahon HT and Gallop JL (2005) Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 438:590-596.
25. Méthot N, Demers CN, and Baenziger JE (1995) Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange. Biochemistry 34:15142-15149.
26. Miller KW (2002) The nature of sites of general anaesthetic action. Br J Anaesth 89:17-31.
27. Overington JP, Al-Lazikani B, and Hopkins AL (2006) How many drug targets are there? Nat Rev Drug Discov 5:993-996.
28. Rankin SE, Addona GH, Kloczewiak MA, Bugge B, and Miller KW (1997) The cholesterol dependence of activation and fast desensitization of the nicotinic acetylcholine receptor. Biophys J 73:2446-2455.
29. Romsicki Y and Sharom FJ (1999) The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry 38:6887-6896.
30. Roth AL and Berg DK (2003) Large clusters of alpha7-containing nicotinic acetylcholine receptors on chick spinal cord neurons. J Comp Neurol 465:195-204.
31. Ryan SE and Baenziger JE (1999) A structure-based approach to nicotinic receptor pharmacology. Mol Pharmacol 55:348-355.
32. Ryan SE, Blanton MP, and Baenziger JE (2001) A conformational intermediate between the resting and desensitized states of the nicotinic acetycholine receptor. J Biol Chem 276:4796-4803.
33. Ryan SE, Demers CN, Chew JP, and Baenziger JE (1996) Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study. J Biol Chem 271:24590- 24597.
34. Ryan SE, Hill DG, and Baenziger JE (2002) Dissecting the chemistry of nicotinic receptor-ligand interactions with infrared difference spectroscopy. J Biol Chem 277:10420-10426.
35. Sine SM and Engel AG (2006) Recent advances in Cys-loop receptor structure and function. Nature 440:448-455.
36. Szabo G, Dolganiuc A, Dai Q, and Pruett SB (2007) TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediate effects. J Immunol 178:1243-1249.
37. Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4Å resolution. J Mol Biol 346:967-989.
38. Vogel R and Siebert F (2003) Fourier transform IR spectroscopy study for new insights into molecular properties and activation mechanisms of visual pigment rhodopsin. Biopolymers 72:133-148.
39. Zhong W, Gallivan JP, Zhang Y, Lintong Li, Lester HA, and Dougherty DA (1998) From ab initio quantum mechanics to molecular neurobiology: a cation-π binding site in the nicotinic receptor. Proc Natl Acad Sci U S A 95:12088-12093.
40. Zhu D, Xiong WC, and Mei L (2006) Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering. J Neurosci 26:4841-4851.